Assessing Responsiveness to RET by Individuals with Chronic Non-fluent Aphasia: A Clinical Perspective

Response elaboration training (RET) is a “loose training” program designed to increase the length and information content of verbal responses of patients with aphasia (Kearns, 1985). Patients have responded robustly to RET regardless of severity level or type of aphasia (Wambaugh, Wright, and Nessler, 2012). One difficulty faced by clinicians seeking to use RET is participants in research studies have usually been treated at a frequency and for a duration that far exceeds standard clinical practice. In order to examine RET from a “clinical perspective,” the researchers carried out a selective meta-analysis of RET focusing on a “window of treatment” that would be commensurate with standard clinical practice

A new approach for quantifying the effects of response elaboration training

Response Elaboration Training (RET; Kearns, 1985, 1986) is a content-driven treatment for individuals with aphasia. Several studies by Kearns and colleagues indicate RET’s unique “loose training” paradigm increases the amount of verbal information produced by individuals with non-fluent Broca’s aphasia in response to picture stimuli (Gaddie, Kearns, & Yedor, 1991; Kearns, 1985, 1986; Kearns & Scher, 1989; Kearns & Yedor, 1991; Nessler, 2009), and that in some cases, RET effects generalize to other speaking partners, stimuli, and settings (Bennett, Wambaugh, & Nesslar, 2005; Gaddie et al., 1991; Kearns & Yedor, 1991). In most RET research, training effects are quantified by having the participant describe the same pictures used in RET. This provision of pictorial support limits conclusions that can be drawn about the effectiveness of RET and its generalizability. The present study examined the effectiveness and generalizability of RET on speaking performance of individuals with non-fluent Broca’s aphasia with a sentence production task (SPT) that did not provide picture support

Identification of Accretion as Grain Growth Mechanism in Astrophysically Relevant Water–Ice Dusty Plasma Experiment

The grain growth process in the Caltech water–ice dusty plasma experiment has been studied using a high-speed camera and a long-distance microscope lens. It is observed that (i) the ice grain number density decreases fourfold as the average grain major axis increases from 20 to 80 μm, (ii) the major axis length has a log-normal distribution rather than a power-law dependence, and (iii) no collisions between ice grains are apparent. The grains have a large negative charge resulting in strong mutual repulsion and this, combined with the fractal character of the ice grains, prevents them from agglomerating. In order for the grain kinetic energy to be sufficiently small to prevent collisions between ice grains, the volumetric packing factor (i.e., ratio of the actual volume to the volume of a circumscribing ellipsoid) of the ice grains must be less than ~0.1 depending on the exact relative velocity of the grains in question. Thus, it is concluded that direct accretion of water molecules is very likely to dominate the observed ice grain growth

Determination of a macro- to micro-scale progression leading to a magnetized plasma disruption

We report the observations of a plasma jet evolving through a macro- to micro-scale progression sequence. This leads to a fast magnetic reconnection that results in the jet breaking off from its originating electrode and forming a force-free state. A sausage-like pinching occurs first and squeezes an initially fat, short magnetized jet so that it becomes thin. The thin jet then becomes kink unstable. The lengthening of the jet by the kinking thins the jet even more since the kink is an incompressible instability. When the jet radius becomes comparable to the ion-skin depth, Hall and electron inertial physics become important and establish the environment for a fast magnetic reconnection. This fast reconnection occurs, disrupting the jet and establishing a force-free state. X-ray bursts and whistler waves, evidence of a magnetic reconnection, are observed when the plasma jet breaks off from the electrode. This experimentally observed sequence of successive thinning from pinching followed by kinking is reproduced in a three-dimensional ideal Magnetohydrodynamic (MHD) numerical simulation. The results of the experiment and the numerical simulation, together demonstrate a viable path from macro-scale MHD physics to micro-scale non-MHD physics where fast reconnection occurs

Determination of a macro- to micro-scale progression leading to a magnetized plasma disruption

We report the observations of a plasma jet evolving through a macro- to micro-scale progression sequence. This leads to a fast magnetic reconnection that results in the jet breaking off from its originating electrode and forming a force-free state. A sausage-like pinching occurs first and squeezes an initially fat, short magnetized jet so that it becomes thin. The thin jet then becomes kink unstable. The lengthening of the jet by the kinking thins the jet even more since the kink is an incompressible instability. When the jet radius becomes comparable to the ion-skin depth, Hall and electron inertial physics become important and establish the environment for a fast magnetic reconnection. This fast reconnection occurs, disrupting the jet and establishing a force-free state. X-ray bursts and whistler waves, evidence of a magnetic reconnection, are observed when the plasma jet breaks off from the electrode. This experimentally observed sequence of successive thinning from pinching followed by kinking is reproduced in a three-dimensional ideal Magnetohydrodynamic (MHD) numerical simulation. The results of the experiment and the numerical simulation, together demonstrate a viable path from macro-scale MHD physics to micro-scale non-MHD physics where fast reconnection occurs

Recruiting, Training, and Engaging Online Faculty via an Award-Winning Virtual Institute -- #USDLA

These are the slides from a webinar for the United States Distance Learning Association (USDLA). Webinar description: At Columbia University's School of Social Work, instructors who teach with the online campus pass a 5-week Institute on Pedagogy and Technology for Online Courses. Launched in 2017, this is a fully virtual professional development training that includes five live class sessions and about 15 hours of homework. Over 400 educators have passed in the first nine cohorts, earning a digital badge. This presentation will share the details of this institute, and how CSSW's online campus uses it to recruit, train, and engage online faculty. This institute was recognized by USDLA with an International Award for Excellence in Training in 2019. It has also been recognized with four other awards: International E-Learning Award (IELA, 2018), Faculty and Staff Development Award (UPCEA Mid-Atlantic, 2019), Learning in Practice Award for Business Impact (Chief Learning Officer Magazine, 2020), and Outstanding Program Award: Noncredit (UPCEA, 2023). To learn more about this institute: *** An article in the Journal of Teaching in Social Work (October 2019): Developing and Supporting Faculty Training for Online Social Work Education: The Columbia University School of Social Work Online Pedagogy Institute. https://doi.org/10.1080/08841233.2019.1653419 *** A United States Distance Learning Association (USDLA) blog post about the Institute, by Valary Oleinik (August 2019): The best teachers are also amazing learners. https://usdla.org/blog/2019/08/21/the-best-teachers-are-also-amazing-learners/ *** A blog post by a past participant in the Institute, Laurel Hitchcock (November 2019): Reflections from the Summer 2019 Institute on Pedagogy and Technology for Online Courses. https://www.laureliversonhitchcock.org/2019/11/19/reflections-from-the-summer-2019-institute-on-pedagogy-and-technology-for-online-courses

Potential Residential Exposure to Toxics Release Inventory Chemicals during Pregnancy and Childhood Brain Cancer

BACKGROUND: Although the susceptibility of the developing fetus to various chemical exposures is well documented, the role of environmental chemicals in childhood brain cancer etiology is not well understood. OBJECTIVES: We aimed to evaluate whether mothers of childhood brain cancer cases had greater potential residential exposure to Toxics Release Inventory (TRI) chemicals than control mothers during pregnancy. METHODS: We included 382 brain cancer cases diagnosed at < 10 years of age from 1993 through 1997 who were identified from four statewide cancer registries. One-to-one matched controls were selected by random-digit dialing. Computer-assisted telephone interviews were conducted. Using residential history of mothers during pregnancy, we measured proximity to TRI facilities and exposure index, including mass and chemicals released. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using conditional logistic regression to estimate brain cancer risk associated with TRI chemicals. RESULTS: Increased risk was observed for mothers living within 1 mi of a TRI facility (OR = 1.66; 95% CI, 1.11–2.48) and living within 1 mi of a facility releasing carcinogens (OR = 1.72; 95% CI, 1.05–2.82) for having children diagnosed with brain cancer before 5 years of age, compared to living > 1 mi from a facility. Taking into account the mass and toxicity of chemical releases, we found a nonsignificant increase in risk (OR = 1.25; 95% CI, 0.67–2.34) comparing those with the lowest versus highest exposure index. CONCLUSIONS: Risk of childhood brain cancers may be associated with living near a TRI facility; however, this is an exploratory study and further studies are needed

Clinical Outcomes for Cystinuria Patients with Unilateral Versus Bilateral Cystine Stone Disease.

INTRODUCTION:Cystinuria is a genetic disorder marked by elevated urinary cystine excretion and recurrent cystine nephrolithiasis. Interestingly, despite seemingly similar contralateral renal anatomy, a subset of cystinuric patients consistently form stones in only one kidney. The aim of this study is to evaluate clinical outcomes in unilateral vs bilateral cystine stone formers. PATIENTS AND METHODS:We performed a retrospective case-control study of cystinuric patients evaluated and treated at the University of California, San Francisco between 1994 and 2015 and categorized patients as either unilateral or bilateral stone formers. Clinical presentation, baseline patient demographics, stone procedures, medical therapy regimens, and long-term renal function were compared between the two groups. RESULTS:A total of 42 cystine stone patients (22 female, 20 male) were included in the analysis. The median age at first presentation was 18.5 years and median age at study conclusion was 45.5 years. Two-thirds of patients (n = 28) had a history of bilateral stones, whereas one-third (n = 14) had unilateral stones. Medical therapy regimens were similar between groups. Despite an increased average number of lifetime surgeries (7.5 sessions for bilateral vs 3.7 sessions for unilateral, p &lt; 0.05), there was no significant difference in medians of the most recent glomerular filtration rate when compared with unilateral stone formers (81.5 vs 95 mL/min, respectively; p = 0.28). CONCLUSIONS:The majority of cystinuric patients within our cohort form stones bilaterally during their lifetime, and require more surgical interventions than unilateral stone formers. Despite this, overall renal function is well preserved in unilateral and bilateral cystinuric stone formers treated with minimally invasive stone extraction procedures

Greater myofibrillar protein synthesis following weight-bearing activity in obese old compared with non-obese old and young individuals

The mechanisms through which obesity impacts age-related muscle mass regulation are unclear. In the present study, rates of integrated myofibrillar protein synthesis (iMyoPS) were measured over 48-h prior-to and following a 45-min treadmill walk in 10 older-obese (O-OB, body fat[%]: 33 ± 3%), 10 older-non-obese (O-NO, 20 ± 3%), and 15 younger-non-obese (Y-NO, 13 ± 5%) individuals. Surface electromyography was used to determine thigh muscle “activation”. Quadriceps cross-sectional area (CSA), volume, and intramuscular thigh fat fraction (ITFF) were measured by magnetic resonance imaging. Quadriceps maximal voluntary contraction (MVC) was measured by dynamometry. Quadriceps CSA and volume were greater (muscle volume, Y-NO: 1182 ± 232 cm3; O-NO: 869 ± 155 cm3; O-OB: 881 ± 212 cm3, P 0.271). Equivalent muscle mass in O-OB may be explained by the muscle anabolic response to weight-bearing activity, whereas the age-related decline in indices of muscle quality appears to be exacerbated in O-OB and warrants further exploration