An investigation of the relationship between rate of responding during and acquisition and resistance to experimental extinction.

Includes bibliographical references.The aim of the present series of experiments was to show that a direct relationship exists between two measures of response strength- rate of responding and resistance to extinction. Experiments I and II used a different subjects design, with three pigeons, one at each level of the independent variable. The results of experiment I (fixed interval schedules) and experiment II (variable interval schedules) were similar - no systematic relationship between the two variables under observation was found. Experiments III and IV controlled individual differences by using multiple schedules of reinforcement. The results of experiment III, where three pigeons were exposed to the same MULT FI schedule yielded a direct function between the two measures of response strength. Experiment IV used a MULT CONJ FI-FR(DRL-DRH) schedule with three pigeons exposed to both levels of the independent variable, so that control could be exercised simultaneously over both number of reinforcements and "time-in-schedule". The trend of the data obtained was in the same direction as that found in experiment III. It was thus concluded, with individual differences controlled for, that rate of responding and resistance to extinction were directly related, and hence adequately mirror response strength

Atomic spectrometry update. Clinical and biological materials, foods and beverages

This review discusses developments in elemental mass spectrometry, atomic absorption, emission and fluorescence, XRF and LIBS, as applied to the analysis of specimens of clinical interest, foods and beverages. Sample preparation procedures and quality assurance are also included.</p

Modelling and Refinement in CODA

This paper provides an overview of the CODA framework for modelling and refinement of component-based embedded systems. CODA is an extension of Event-B and UML-B and is supported by a plug-in for the Rodin toolset. CODA augments Event-B with constructs for component-based modelling including components, communications ports, port connectors, timed communications and timing triggers. Component behaviour is specified through a combination of UML-B state machines and Event-B. CODA communications and timing are given an Event-B semantics through translation rules. Refinement is based on Event-B refinement and allows layered construction of CODA models in a consistent way.Comment: In Proceedings Refine 2013, arXiv:1305.563

Post-operative atrial fibrillation is influenced by beta-blocker therapy but not by pre-operative atrial cellular electrophysiology

We investigated whether post-cardiac surgery (CS) new-onset atrial fibrillation (AF) is predicted by pre-CS atrial cellular electrophysiology, and whether the antiarrhythmic effect of beta-blocker therapy may involve pre-CS pharmacological remodeling. Atrial myocytes were obtained from consenting patients in sinus rhythm, just prior to CS. Action potentials and ion currents were recorded using whole-cell patch-clamp technique. Post-CS AF occurred in 53 of 212 patients (25%). Those with post-CS AF were older than those without (67 ± 2 vs 62 ± 1 years, P = 0.005). In cells from patients with post-CS AF, the action potential duration at 50% and 90% repolarization, maximum upstroke velocity, and effective refractory period (ERP) were 13 ± 4 ms, 217 ± 16 ms, 185 ± 10 V/s, and 216 ± 14 ms, respectively (n = 30 cells, 11 patients). Peak L-type Ca2+ current, transient outward and inward rectifier K+ currents, and the sustained outward current were −5.0 ± 0.5, 12.9 ± 2.4, −4.1 ± 0.4, and 9.7 ± 1.0 pA/pF, respectively (13-62 cells, 7-19 patients). None of these values were significantly different in cells from patients without post-CS AF (P > 0.05 for each, 60-279 cells, 29-86 patients), confirmed by multiple and logistic regression. In patients treated >7 days with a beta-blocker pre-CS, the incidence of post-CS AF was lower than in non-beta-blocked patients (13% vs 27%, P = 0.038). Pre-CS beta-blockade was associated with a prolonged pre-CS atrial cellular ERP (P = 0.001), by a similar degree (∼20%) in those with and without post-CS AF. Conclusion: Pre-CS human atrial cellular electrophysiology does not predict post-CS AF. Chronic beta-blocker therapy is associated with a reduced incidence of post-CS AF, unrelated to a pre-CS ERP-prolonging effect of this treatment

The Amundsen Sea low

We develop a climatology of the Amundsen Sea low (ASL) covering the period 1979–2008 using ECMWF operational and reanalysis fields. The depth of the ASL is strongly influenced by the phase of the Southern annular mode (SAM) with positive (negative) mean sea level pressure anomalies when the SAM is negative (positive). The zonal location of the ASL is linked to the phase of the mid-tropospheric planetary waves and the low moves west from close to 110°W in January to near 150°W in June as planetary waves 1 to 3 amplify and their phases shift westwards. The ASL is deeper by a small, but significant amount, during the La Niña phase of El Niño-Southern Oscillation (ENSO) compared to El Niño. The difference in depth of the low between the two states of ENSO is greatest in winter. There is no statistically significant difference in the zonal location of the ASL between the different phases of ENSO. Over 1979–2008 the low has deepened in January by 1.7 hPa dec−1 as the SAM has become more positive. It has also deepened in spring and autumn as the semi-annual oscillation has increase in amplitude over the last 30 years. An increase in central pressure and eastward shift in March has occurred as a result of a cooling of tropical Pacific SSTs that altered the strength of the polar front jet

Time-varying investment barriers and closed-end country fund pricing

We examine the effect of time-varying investment barriers on the pricing of UK closed-end emerging market country funds. We find that a direct measure of capital market segmentation is significantly negatively related to both country fund stock return and Net Asset Value (NAV) return of the fund, but there is no relation to the premium. Also we find some evidence of a positive relation for an indirect barrier (inflation variability) and stock return, NAV return and the premium. Overall our results support an information hypothesis of the impact of investment barriers on closed-end fund pricing

Scheduling of eccentric lower limb injury prevention exercises during the soccer micro-cycle: Which day of the week?

Scheduling eccentric-based injury prevention programs (IPP) during the common 6-day micro-cycle in soccer is challenged by recovery and tapering phases. This study profiled muscle damage, neuromuscular performance, and perceptual responses to a lower limb eccentric-based IPP administered 1 (MD+1) vs 3 days (MD+3) postmatch. A total of 18 semi-professional players were monitored daily during 3 in-season 6-day micro-cycles, including weekly competitive fixtures. Capillary creatine kinase concentration (CK), posterior lower limb isometric peak force (PF), counter-movement jump (CMJ) performance, and muscle soreness were assessed 24 hours prior to match-day (baseline), and every 24 hours up to 120 hours postmatch. The IPP consisted of lunges, single stiff leg dead-lifts, single leg-squats, and Nordic hamstring exercises. Performing the IPP on MD+1 attenuated the decline in CK normally observed following match play (CON: 142%; MD+3: 166%; small differences). When IPP was delivered on MD+3, CK was higher vs CON and MD+1 trials on both MD+4 (MD+3: 260%; CON: 146%; MD+1: 151%; moderate differences) and MD+5 (MD+3: 209%; CON: 125%; MD+1: 127%; small differences). Soreness ratings were not exacerbated when the IPP was delivered on MD+1, but when prescribed on MD+3, hamstring soreness ratings remained higher on MD+4 and MD+5 (small differences). No between-trial differences were observed for PF and CMJ. Administering the IPP in the middle of the micro-cycle (MD+3) increased measures of muscle damage and soreness, which remained elevated on the day prior to the next match (MD+5). Accordingly, IPP should be scheduled early in the micro-cycle, to avoid compromising preparation for the following match

A Review of NASA's Radiation-Hardened Electronics for Space Environments Project

NASA's Radiation Hardened Electronics for Space Exploration (RHESE) project develops the advanced technologies required to produce radiation hardened electronics, processors, and devices in support of the requirements of NASA's Constellation program. Over the past year, multiple advancements have been made within each of the RHESE technology development tasks that will facilitate the success of the Constellation program elements. This paper provides a brief review of these advancements, discusses their application to Constellation projects, and addresses the plans for the coming year