64 research outputs found
Structural and molecular correlates of cognitive aging in the rat
Aging is associated with cognitive decline. Herein, we studied a large cohort of old age and young adult male rats and confirmed that, as a group, old rats display poorer spatial learning and behavioral flexibility than younger adults. Surprisingly, when animals were clustered as good and bad performers, our data revealed that while in younger animals better cognitive performance was associated with longer dendritic trees and increased levels of synaptic markers in the hippocampus and prefrontal cortex, the opposite was found in the older group, in which better performance was associated with shorter dendrites and lower levels of synaptic markers. Additionally, in old, but not young individuals, worse performance correlated with increased levels of BDNF and the autophagy substrate p62, but decreased levels of the autophagy complex protein LC3. In summary, while for younger individuals "bigger is better", "smaller is better" is a more appropriate aphorism for older subjects.Portuguese Foundation for Science and Technology (FCT) with fellowships granted to: Cristina Mota (SFRH/BD/81881/2011), Susana Monteiro (SFRH/BD/69311/2010), Sofia Pereira das Neves and Sara Monteiro-Martins (PIC/IC/83213/2007); and by the European Commission within the 7th framework program, under the grant agreement: Health-F2-2010-259772 (Switchbox). In addition, this work was co-funded by the Northern Portugal Regional Operational Programme (ON.2 SR&TD Integrated Program – NORTE-07-0124-FEDER-000021), through the European Regional Development Fund (FEDER) and by national funds granted by FCT (PEst-C/SAU/LA0026/2013), and FEDER through the COMPETE (FCOMP-01-0124-FEDER-037298)
Scots pine (Pinus sylvestris L.) site index in relation to physico-chemical and biological properties in reclaimed mine soils
Plant interspecific differences in arbuscular mycorrhizal colonization as a result of soil carbon addition
Endogenous luteinizing hormone release using human menopausal gonadotropins for in vitro fertilization
The effect of pregnant mare serum gonadotropin on mouse embryos fertilized in vivo or in vitro
Effect of human follicular fluids from pregnant and nonpregnant patients on the development of mouse zygotes in vitro
Cinical experiences with in vitro fertilization-embryo transfer at Mount Sinai Hospital Medical Center of Chicago
A mobile oocyte incubation unit (MOIU): A device for improvement of the gamete intrafallopian transfer (GIFT) program
- …