RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells.

A subset of retinal ganglion cells is intrinsically photosensitive (ipRGCs) and contributes directly to the pupillary light reflex and circadian photoentrainment under bright-light conditions. ipRGCs are also indirectly activated by light through cellular circuits initiated in rods and cones. A mammalian homologue (RdgB2) of a phosphoinositide transfer/exchange protein that functions in Drosophila phototransduction is expressed in the retinal ganglion cell layer. This raised the possibility that RdgB2 might function in the intrinsic light response in ipRGCs, which depends on a cascade reminiscent of Drosophila phototransduction. Here we found that under high light intensities, RdgB2(-/-) mutant mice showed normal pupillary light responses and circadian photoentrainment. Consistent with this behavioral phenotype, the intrinsic light responses of ipRGCs in RdgB2(-/-) were indistinguishable from wild-type. In contrast, under low-light conditions, RdgB2(-/-) mutants displayed defects in both circadian photoentrainment and the pupillary light response. The RdgB2 protein was not expressed in ipRGCs but was in GABAergic amacrine cells, which provided inhibitory feedback onto bipolar cells. We propose that RdgB2 is required in a cellular circuit that transduces light input from rods to bipolar cells that are coupled to GABAergic amacrine cells and ultimately to ipRGCs, thereby enabling ipRGCs to respond to dim light

Reduced tillage in corn production

Caption title."Corn Belt Branch, Soil and Water Conservation Research Division, Agricultural Research Service, U.S. Department of Agriculture, Columbia, Missouri and the Agricultural Engineering Department of the Missouri Agricultural Experiment Station Cooperating"--Page [2]

How to Resolve an Ethical Dilemma Concerning Randomized Clinical Trials

An apparent ethical dilemma arises when physicians consider enrolling their patients in randomized clinical trials. Suppose that a randomized clinical trial comparing two treatments is in progress, and a physician has an opinion about which treatment is better. The physician has a duty to promote the patient's best medical interests and therefore seems to be obliged to advise the patient to receive the treatment that the physician prefers. This duty creates a barrier to the enrollment of patients in randomized clinical trials.1-10 Two strategies are often used to resolve the dilemma in favor of enrolling patients in clinical trials

Using LP gas as a tractor fuel

Cover title

The definability criterions for convex projective polyhedral reflection groups

Following Vinberg, we find the criterions for a subgroup generated by reflections \Gamma \subset \SL^{\pm}(n+1,\mathbb{R}) and its finite-index subgroups to be definable over $\mathbb{A}$ where $\mathbb{A}$ is an integrally closed Noetherian ring in the field $\mathbb{R}$. We apply the criterions for groups generated by reflections that act cocompactly on irreducible properly convex open subdomains of the $n$-dimensional projective sphere. This gives a method for constructing injective group homomorphisms from such Coxeter groups to \SL^{\pm}(n+1,\mathbb{Z}). Finally we provide some examples of \SL^{\pm}(n+1,\mathbb{Z})-representations of such Coxeter groups. In particular, we consider simplicial reflection groups that are isomorphic to hyperbolic simplicial groups and classify all the conjugacy classes of the reflection subgroups in \SL^{\pm}(n+1,\mathbb{R}) that are definable over $\mathbb{Z}$. These were known by Goldman, Benoist, and so on previously.Comment: 31 pages, 8 figure

Statistical mechanics of voting

Decision procedures aggregating the preferences of multiple agents can produce cycles and hence outcomes which have been described heuristically as `chaotic'. We make this description precise by constructing an explicit dynamical system from the agents' preferences and a voting rule. The dynamics form a one dimensional statistical mechanics model; this suggests the use of the topological entropy to quantify the complexity of the system. We formulate natural political/social questions about the expected complexity of a voting rule and degree of cohesion/diversity among agents in terms of random matrix models---ensembles of statistical mechanics models---and compute quantitative answers in some representative cases.Comment: 9 pages, plain TeX, 2 PostScript figures included with epsf.tex (ignore the under/overfull \vbox error messages

Report of the GDR working group on the R-parity violation

This report summarizes the work of the "R-parity violation group" of the French Research Network (GDR) in Supersymmetry, concerning the physics of supersymmetric models without conservation of R-parity at HERA, LEP, Tevatron and LHC and limits on R-parity violating couplings from various processes. The report includes a discussion of the recent searches at the HERA experiment, prospects for new experiments, a review of the existing limits, and also theoretically motivated alternatives to R-parity and a brief discussion on the implications of R-parity violation on the neutrino masses.Comment: 60 pages, LaTeX, 22 figures, 2 table