American palm ethnomedicine: A meta-analysis

<p>Abstract</p> <p>Background</p> <p>Many recent papers have documented the phytochemical and pharmacological bases for the use of palms (<it>Arecaceae</it>) in ethnomedicine. Early publications were based almost entirely on interviews that solicited local knowledge. More recently, ethnobotanically guided searches for new medicinal plants have proven more successful than random sampling for identifying plants that contain biodynamic ingredients. However, limited laboratory time and the high cost of clinical trials make it difficult to test all potential medicinal plants in the search for new drug candidates. The purpose of this study was to summarize and analyze previous studies on the medicinal uses of American palms in order to narrow down the search for new palm-derived medicines.</p> <p>Methods</p> <p>Relevant literature was surveyed and data was extracted and organized into medicinal use categories. We focused on more recent literature than that considered in a review published 25 years ago. We included phytochemical and pharmacological research that explored the importance of American palms in ethnomedicine.</p> <p>Results</p> <p>Of 730 species of American palms, we found evidence that 106 species had known medicinal uses, ranging from treatments for diabetes and leishmaniasis to prostatic hyperplasia. Thus, the number of American palm species with known uses had increased from 48 to 106 over the last quarter of a century. Furthermore, the pharmacological bases for many of the effects are now understood.</p> <p>Conclusions</p> <p>Palms are important in American ethnomedicine. Some, like <it>Serenoa repens </it>and <it>Roystonea regia</it>, are the sources of drugs that have been approved for medicinal uses. In contrast, recent ethnopharmacological studies suggested that many of the reported uses of several other palms do not appear to have a strong physiological basis. This study has provided a useful assessment of the ethnobotanical and pharmacological data available on palms.</p

Measurement of the tt¯ production cross-section using eμ events with b-tagged jets in pp collisions at √s=7 and 8 TeV with the ATLAS detector

The inclusive top quark pair (tt¯tt¯) production cross-section σtt¯σtt¯ has been measured in proton–proton collisions at s√=7 TeVs=7 TeV and s√=8 TeVs=8 TeV with the ATLAS experiment at the LHC, using tt¯tt¯ events with an opposite-charge eμeμ pair in the final state. The measurement was performed with the 2011 7 TeV dataset corresponding to an integrated luminosity of 4.6 fb−1fb−1 and the 2012 8 TeV dataset of 20.3 fb−1fb−1. The numbers of events with exactly one and exactly two bb-tagged jets were counted and used to simultaneously determine σtt¯σtt¯ and the efficiency to reconstruct and bb-tag a jet from a top quark decay, thereby minimising the associated systematic uncertainties. The cross-section was measured to be: σtt¯σtt¯=182.9±3.1±4.2±3.6±3.3 pb (s√=7 TeV)and=242.4±1.7±5.5±7.5±4.2 pb (s√=8 TeV), σtt¯=182.9±3.1±4.2±3.6±3.3 pb (s=7 TeV)andσtt¯=242.4±1.7±5.5±7.5±4.2 pb (s=8 TeV), where the four uncertainties arise from data statistics, experimental and theoretical systematic effects, knowledge of the integrated luminosity and of the LHC beam energy. The results are consistent with recent theoretical QCD calculations at next-to-next-to-leading order. Fiducial measurements corresponding to the experimental acceptance of the leptons are also reported, together with the ratio of cross-sections measured at the two centre-of-mass energies. The inclusive cross-section results were used to determine the top quark pole mass via the dependence of the theoretically predicted cross-section on mpoletmtpole giving a result of mpoletmtpole=172.9+2.5−2.6=172.9−2.6+2.5 GeV. By looking for an excess of tt¯tt¯ production with respect to the QCD prediction, the results were also used to place limits on the pair-production of supersymmetric top squarks t~1t~1 with masses close to the top quark mass, decaying via t~1→tχ~01t~1→tχ~10 to predominantly right-handed top quarks and a light neutralino χ~01χ~10, the lightest supersymmetric particle. Top squarks with masses between the top quark mass and 177 GeV are excluded at the 95 % confidence level

Agravos clínicos atendidos pelo Serviço de Atendimento Móvel de Urgência (SAMU) de Porto Alegre - RS Agravios clínicos atendidos por el Servicio de Atención Móvil de Urgencia (SAMU) de Porto Alegre - RS Conditions treated in the Mobile Medical Emergency Services in Porto Alegre - RS

OBJETIVO: Caracterizar os agravos clínicos atendidos pelo Serviço de Atendimento Móvel de Urgência (SAMU), de Porto Alegre, no período de janeiro a junho de 2008. MÉTODOS: Estudo transversal, descritivo, exploratório. Utilizaram-se dados do sistema de informações do SAMU que foram transportados para o Programa Excel. O tratamento e análise dos dados foram descritivos. RESULTADOS: Os agravos neurológicos, cardiovasculares, respiratórios, digestivos e metabólicos foram os mais prevalentes, e a maioria ocorreu na faixa etária de 41-60 anos. Os hospitais públicos e unidades de pronto-atendimento foram as principais portas de entrada dos pacientes atendidos pelo SAMU. CONCLUSÃO: Os resultados podem contribuir para uma melhor organização do serviço e apontam necessidades de qualificação do atendimento de enfermagem que tem participação decisiva no cuidado ao paciente.<br>OBJETIVO: Caracterizar los agravios clínicos atendidos por el Servicio de Atención Móvil de Urgencia (SAMU), de Porto Alegre, en el período de enero a junio del 2008. MÉTODOS: Estudo transversal, descriptivo, exploratorio. Se utilizaron datos del sistema de informaciones del SAMU que fueron pasados al Programa Excel. El tratamiento y análisis de los datos fueron descriptivos. RESULTADOS: Los agravios neurológicos, cardiovasculares, respiratorios, digestivos y metabólicos fueron los más prevalentes, y la mayoría ocurrió en el grupo etáreo de 41-60 años. Los hospitales públicos y unidades de pronta-atención fueron las principales puertas de entrada de los pacientes atendidos por el SAMU. CONCLUSION: Los resultados pueden contribuir para una mejor organización del servicio y señalan necesidades de calificación de la atención de enfermería que tiene participación decisiva en el cuidado al paciente.<br>OBJECTIVE: To characterize the conditions treated in the Mobile Medical Emergency Services (SAMU) in Porto Alegre, from January to June 2008. METHODS: A cross- sectional, descriptive and exploratory study was performed. Data from the information system of the SAMU were used, which were dowloaded into the Microsoft Excel program. Descriptive data analysis was performed. RESULTS: Neurologic, cardiovascular, respiratory, digestive and metabolic disorders were most prevalent; most of these occurred in the age group ranging between 41-60 years. Public hospitals and emergency care units were the main ports of entry for patients treated at SAMU. CONCLUSION: These results may contribute to better organization and point of service qualification requirements for the nursing staff that has substantial involvement in patient care

New designs for MRI contrast agents

New designs for Magnetic Resonance Imaging contrast agents are presented. Essentially, they all are host-guest inclusion complexes between γ-cyclodextrins and polyazamacrocycles of gadolinium (III) ion. Substitutions have been made to the host to optimise the host-guest association. Molecular mechanics calculations have been performed, using the UFF force field for metals, to decide on the suitability of the substitutions, and to evaluate the host-guest energies of association. Interesting general conclusions have been obtained, concerning the improvement of Magnetic Resonance Imaging contrast agents; namely, a set of rational methodologies have been deduced to improve the association between the gadolinium (III) chelates and the cyclodextrins, and their efficiency is demonstrated with a large set of substituted complexes, opening new doors to increase the diagnostic capabilities of Magnetic Resonance Imaging

Fibromyalgia: is there association between balance and pain? a pilot study

Studies of balance and risk factors for falling typically focus on the elderly population or on individuals with musculoskeletal pain. Although fibromyalgia is associated with intrinsic factors that predispose to falls (pain, depression, fatigue), few studies have researched balance and falls in this syndrome. The aim of this study was to verify the association between balance, balance self-efficacy and pain in women with and without fibromyalgia, and verify the association between Berg Balance Scale and Activities-specific Balance Confidence Scale (ABC Scale). The sample consisted of 48 women aged between 40 and 59 years, divided into two groups: Fibromyalgia group (n=22) and Control group (n=26) with asymptomatic people. Balance was assessed by Berg Balance Scale, balance self-efficacy by the ABC Scale and pain by the visual analog scale. Mean scores for pain, Berg and ABC Scale were 5.4 cm (SD 2.6), 55 (interquartile range 54-56), and 54.6 (SD 26.6) respectively for Fibromyalgia group, and 0 cm, 56 (interquartile range 55-56), and 89.4 (SD 14.4) respectively for Control group. Statistically significant differences were found in balance on comparing both groups (p=0.000 for Berg Balance Scale and 0.009 for ABC Scale) with lower values for Fibromyalgia group. In Fibromyalgia group, pain was negatively correlated with balance (r=-0.48, p=0.020) and balance self-efficacy (rs=-0.56, p=0.006). Correlation between Berg Balance Scale and ABC Scale was found only in the Fibromyalgia group (rs =0.55, p=0.007). There are associations between poor balance and pain, and poor balance and decreased balance self-efficacy in women with fibromyalgia. There is an association between scales in the Fibromyalgia group