Synthesis of Several New Schiff Bases Linked to Sulfonamido Naphthalimide Moiety with Expected Biological Activity.

Several new Schiff bases linked to sulfonamidonaphthalimide moiety have been synthesized. The first step in this work involved introducing of 4-(N-naphthalimidyl) phenyl sulfonylchloride in amination reaction with hydrazine hydrate producing 4-(N-naphthalimidyl) phenyl sulfonylhydrazine. Introducing of the prepared sulfonyl hydrazine in condensation reaction with different substituted aromatic aldehydes in the second step afforded the target new Schiff bases. Structures of the prepared compounds were elucidated on the basis of FTIR, 1HNMR, 13CNMR spectral data which agreed with the proposed structures. The newly synthesized compounds are expected to have biological activity scince they are built from biologically active components including naphthalimide, sulfonylimide and Schiff base