Technical summary: Feasibility study of conductivity monitoring for leak detection in double-walled plutonium containers

Currently, the storage container for the pit from a dismantled warhead is a sealed outer container, or drum, within which the pit is suspended. Since the pit itself is a sealed, stainless steel container for the plutonium, the inner plus the outer containers constitute the {open_quotes}double-walled{close_quotes} configuration for plutonium storage. If either inner or outer wall of the container fails, the fill-gas between the pit and drum walls will contain species that will modify the physical properties of that gas. The work summarized here reports the initial feasibility study for an innovative approach for monitoring for leakages both for radioactive materials from the pit and for the intrusion of outside into the drum by monitoring the electrical conductivity of the fill-gas. For the gas present in a drum containing a pit, alphas from decays of plutonium are stopped by the primary container wall of the pit itself unless pit leakage occurs. If plutonium leaks from the pit and enters the fill-gas (either noble gas or air) of the outer container, each of the alpha particles due to the decay of plutonium will create about 10{sup 5} electron-ion pairs along its track. If the fill gas is a noble gas, these electrons will diffuse in the gas as free electrons

A quinazoline-based HDAC inhibitor affects gene expression pathways involved in cholesterol biosynthesis and mevalonate in prostate cancer cells

Chronic inflammation can lead to the development of cancers and resolution of inflammation is an ongoing challenge.</p

Absorption spectrum in the wings of the potassium second resonance doublet broadened by helium

We have measured the reduced absorption coefficients occurring in the wings of the potassium 4S-5P doublet lines at 404.414 nm and at 404.720 nm broadened by helium gas at pressures of several hundred Torr. At the experimental temperature of 900 K, we have detected a shoulder-like broadening feature on the blue wing of the doublet which is relatively flat between 401.8 nm and 402.8 nm and which drops off rapidly for shorter wavelengths, corresponding to absorption from the X doublet Sigma+ state to the C doublet Sigma+ state of the K-He quasimolecule. The accurate measurements of the line profiles in the present work will sharply constrain future calculations of potential energy surfaces and transition dipole moments correlating to the asymptotes He-K(5p), He-K(5s), and He-K(3d).Comment: 2 figure

CLASS B0827+525: `Dark lens' or binary radio-loud quasar?

We present radio, optical, near-infrared and spectroscopic observations of the source B0827+525. We consider this source as the best candidate from the Cosmic Lens All-Sky Survey (CLASS) for a `dark lens' system or binary radio-loud quasar. The system consists of two radio components with somewhat different spectral indices, separated by 2.815 arcsec. VLBA observations show that each component has substructure on a scale of a few mas. A deep K-band exposure with the W.M.Keck-II Telescope reveals emission near both radio components. The K-band emission of the weaker radio component appears extended, whereas the emission from the brighter radio component is consistent with a point source. Hubble Space Telescope F160W-band observations with the NICMOS instrument confirms this. A redshift of 2.064 is found for the brighter component, using the LRIS instrument on the W.M.Keck-II Telescope. The probability that B0827+525 consists of two unrelated compact flat-spectrum radio sources is ~3%, although the presence of similar substructure in both component might reduce this. We discuss two scenarios to explain this system: (i) CLASS B0827+525 is a `dark lens' system or (ii) B0827+525 is a binary radio-loud quasar. B0827+525 has met all criteria that thus far have in 100% of the cases confirmed a source as an indisputable gravitational lens system. Despite this, no lens galaxy has been detected with m_F160W<=23 mag. Hence, we might have found the first binary radio-loud quasar. At this moment, however, we feel that the `dark lens' hypothesis cannot yet be fully excluded.Comment: 9 pages, 6 figures; Accepted for publication in Astronomy & Astrophysics; Full-res. images 1 and 3 can be obtained from L.V.E.

Probing the Sensitivity of Electron Wave Interference to Disorder-Induced Scattering in Solid-State Devices

The study of electron motion in semiconductor billiards has elucidated our understanding of quantum interference and quantum chaos. The central assumption is that ionized donors generate only minor perturbations to the electron trajectories, which are determined by scattering from billiard walls. We use magnetoconductance fluctuations as a probe of the quantum interference and show that these fluctuations change radically when the scattering landscape is modified by thermally-induced charge displacement between donor sites. Our results challenge the accepted understanding of quantum interference effects in nanostructures.Comment: 8 pages, 5 figures, Submitted to Physical Review

Structure and mechanism of acetolactate decarboxylase

Acetolactate decarboxylase catalyzes the conversion of both enantiomers of acetolactate to the (R)-enantiomer of acetoin, via a mechanism that has been shown to involve a prior rearrangement of the non-natural (R)-enantiomer substrate to the natural (S)-enantiomer. In this paper, a series of crystal structures of ALDC complex with designed transition state mimics are reported. These structures, coupled with inhibition studies and site-directed mutagenesis provide an improved understanding of the molecular processes involved in the stereoselective decarboxylation/protonation events. A mechanism for the transformation of each enantiomer of acetolactate is proposed

The composite first person narrative: Texture, structure, and meaning in writing phenomenological descriptions

This paper illustrates the use of composite first person narrative interpretive methods, as described by Todres, across a range of phenomena. This methodology introduces texture into the presently understood structures of phenomena and thereby creates new understandings of the phenomenon, bringing about a form of understanding that is relationally alive that contributes to improved caring practices. The method is influenced by the work of Gendlin, Heidegger, van Manen, Gadamer, and Merleau-Ponty. The method's applicability to different research topics is demonstrated through the composite narratives of nursing students learning nursing practice in an accelerated and condensed program, obese female adolescents attempting weight control, chronically ill male parolees, and midlife women experiencing distress during menopause. Within current research, these four phenomena have been predominantly described and understood through quantified articulations that give the reader a structural understanding of the phenomena, but the more embodied or “contextual” human qualities of the phenomena are often not visible. The “what is it like” or the “unsaid” aspects of such human phenomena are not clear to the reader when proxies are used to “account for” a variety of situated conditions. This novel method is employed to re-present narrative data and findings from research through first person accounts that blend the voices of the participants with those of the researcher, emphasizing the connectedness, the “we” among all participants, researchers, and listeners. These re-presentations allow readers to develop more embodied understandings of both the texture and structure of each of the phenomena and illustrate the use of the composite account as a way for researchers to better understand and convey the wholeness of the experience of any phenomenon under inquiry

Effects of gestational age at birth on cognitive performance : a function of cognitive workload demands

Objective: Cognitive deficits have been inconsistently described for late or moderately preterm children but are consistently found in very preterm children. This study investigates the association between cognitive workload demands of tasks and cognitive performance in relation to gestational age at birth. Methods: Data were collected as part of a prospective geographically defined whole-population study of neonatal at-risk children in Southern Bavaria. At 8;5 years, n = 1326 children (gestation range: 23–41 weeks) were assessed with the K-ABC and a Mathematics Test. Results: Cognitive scores of preterm children decreased as cognitive workload demands of tasks increased. The relationship between gestation and task workload was curvilinear and more pronounced the higher the cognitive workload: GA2 (quadratic term) on low cognitive workload: R2 = .02, p<0.001; moderate cognitive workload: R2 = .09, p<0.001; and high cognitive workload tasks: R2 = .14, p<0.001. Specifically, disproportionally lower scores were found for very (<32 weeks gestation) and moderately (32–33 weeks gestation) preterm children the higher the cognitive workload of the tasks. Early biological factors such as gestation and neonatal complications explained more of the variance in high (12.5%) compared with moderate (8.1%) and low cognitive workload tasks (1.7%). Conclusions: The cognitive workload model may help to explain variations of findings on the relationship of gestational age with cognitive performance in the literature. The findings have implications for routine cognitive follow-up, educational intervention, and basic research into neuro-plasticity and brain reorganization after preterm birth

Minkowski Tensors of Anisotropic Spatial Structure

This article describes the theoretical foundation of and explicit algorithms for a novel approach to morphology and anisotropy analysis of complex spatial structure using tensor-valued Minkowski functionals, the so-called Minkowski tensors. Minkowski tensors are generalisations of the well-known scalar Minkowski functionals and are explicitly sensitive to anisotropic aspects of morphology, relevant for example for elastic moduli or permeability of microstructured materials. Here we derive explicit linear-time algorithms to compute these tensorial measures for three-dimensional shapes. These apply to representations of any object that can be represented by a triangulation of its bounding surface; their application is illustrated for the polyhedral Voronoi cellular complexes of jammed sphere configurations, and for triangulations of a biopolymer fibre network obtained by confocal microscopy. The article further bridges the substantial notational and conceptual gap between the different but equivalent approaches to scalar or tensorial Minkowski functionals in mathematics and in physics, hence making the mathematical measure theoretic method more readily accessible for future application in the physical sciences

NICMOS images of JVAS/CLASS gravitational lens systems

We present Hubble Space Telescope (HST) infrared images of four gravitational lens systems from the JVAS/CLASS gravitational lens survey and compare the new infrared HST pictures with previously published WFPC2 HST optical images and radio maps. Apart from the wealth of information that we get from the flux ratios and accurate positions and separations of the components of the lens systems that we can use as inputs for better constraints on the lens models we are able to discriminate between reddening and optical/radio microlensing as the possible cause of differences observed in the flux ratios of the components across the three wavelength bands. Substantial reddening has been known to be present in the lens system B1600+434 and has been further confirmed by the present infrared data. In the two systems B0712+472 and B1030+074 microlensing has been pinpointed down as the main cause of the flux ratio discrepancy both in the optical/infrared and in the radio, the radio possibly caused by the substructure revealed in the lensing galaxies. In B0218+357 however the results are still not conclusive. If we are actually seeing the two "true" components of the lens system then the flux ratio differences are attributed to a combination of microlensing and reddening or alternatively due to some variability in at least one of the images. Otherwise the second "true" component of B0218+357 maybe completely absorbed by a molecular cloud and the anomalous flux density ratios and large difference in separation between the optical/infrared and radio that we see can be explained by emission from either a foreground object or from part of the lensing galaxy.Comment: 10 pages, 4 figures (original higher resolution figures can be obtained at the e-mail above), to appear in MNRAS (accepted