1-Bromo-2-(10β-dihydro­artemisin­oxy)ethane

The title compound, C17H27BrO5, DEB, is a derivative of artemisinin which is used in malara therapy. The OR-group at C12 is cis to the CH3-group at C11 and axially oriented on ring D which has a chair conformation. The crystal packing is stabilized by several weak inter­molecular C—H⋯O inter­actions, which combine to form a C—H—O bonded network parallel to (001)

Artemisinin quinoline hybrid-dimers: synthesis and in vitro antiplasmodial activity

Novel artemisinin–quinoline hybrid-dimers were synthesized from dihydroartemisinin and different aminoquinolines at elevated temperatures (90–110 °C). All compounds were obtained as the β-isomers and were tested against both chloroquine sensitive and resistant strains of Plasmodium falciparum. Hybrid-dimer 8 showed the highest antiplasmodial activity, inheriting the optimum chain length of three carbon atom