6 research outputs found
A quantitative test of the mode-coupling theory of the ideal glass transition for a binary Lennard-Jones system
Using a molecular dynamics computer simulation we determine the temperature
dependence of the partial structure factors for a binary Lennard-Jones system.
These structure factors are used as input data to solve numerically the
wave-vector dependent mode-coupling equations in the long time limit. Using the
so determined solutions, we compare the predictions of mode-coupling theory
(MCT) with the results of a previously done molecular dynamics computer
simulation [Phys. Rev. E 51, 4626 (1995), ibid. 52, 4134 (1995)]. From this
comparison we conclude that MCT gives a fair estimate of the critical coupling
constant, a good estimate of the exponent parameter, predicts the wave-vector
dependence of the various nonergodicity parameters very well, except for very
large wave-vectors, and gives also a very good description of the space
dependence of the various critical amplitudes. In an attempt to correct for
some of the remaining discrepancies between the theory and the results of the
simulation, we investigate two small (ad hoc) modifications of the theory. We
find that one modification gives a worse agreement between theory and
simulation, whereas the second one leads to an improved agreement.Comment: Figures available from W. Ko
Model for Glass Transition in a Binary fluid from a Mode Coupling approach
We consider the Mode Coupling Theory (MCT) of Glass transition for a Binary
fluid. The Equations of Nonlinear Fluctuating Hydrodynamics are obtained with a
proper choice of the slow variables corresponding to the conservation laws. The
resulting model equations are solved in the long time limit to locate the
dynamic transition. The transition point from our model is considerably higher
than predicted in existing MCT models for binary systems. This is in agreement
with what is seen in Computer Simulation of binary fluids. fluids.Comment: 9 Pages, 3 Figure
Serotonin transporter genotype modulates resting state and predator stress-induced amygdala perfusion in mice in a sex-dependent manner.
The serotonin transporter (5-HTT) is a key molecule of serotoninergic neurotransmission and target of many anxiolytics and antidepressants. In humans, 5-HTT gene variants resulting in lower expression levels are associated with behavioral traits of anxiety. Furthermore, functional magnetic resonance imaging (fMRI) studies reported increased cerebral blood flow (CBF) during resting state (RS) and amygdala hyperreactivity. 5-HTT deficient mice as an established animal model for anxiety disorders seem to be well suited for investigating amygdala (re-)activity in an fMRI study. We investigated wildtype (5-HTT+/+), heterozygous (5-HTT+/-), and homozygous 5-HTT-knockout mice (5-HTT-/-) of both sexes in an ultra-high-field 17.6 Tesla magnetic resonance scanner. CBF was measured with continuous arterial spin labeling during RS, stimulation state (SS; with odor of rats as aversive stimulus), and post-stimulation state (PS). Subsequently, post mortem c-Fos immunohistochemistry elucidated neural activation on cellular level. The results showed that in reaction to the aversive odor CBF in total brain and amygdala of all mice significantly increased. In male 5-HTT+/+ mice amygdala RS CBF levels were found to be significantly lower than in 5-HTT+/- mice. From RS to SS 5-HTT+/+ amygdala perfusion significantly increased compared to both 5-HTT+/- and 5-HTT-/- mice. Perfusion level changes of male mice correlated with the density of c-Fos-immunoreactive cells in the amygdaloid nuclei. In female mice the perfusion was not modulated by the 5-Htt-genotype, but by estrous cycle stages. We conclude that amygdala reactivity is modulated by the 5-Htt genotype in males. In females, gonadal hormones have an impact which might have obscured genotype effects. Furthermore, our results demonstrate experimental support for the tonic model of 5-HTTLPR function