No Fine End for a Modern Day Alice in Transit

To the reader---; How I live is a giant writing thing, even when I\u27m not writing. There is always breath, both shallow and deep, and somewhere, wet jackets, sides of the same world. It is about the blob, mostly because all of this has been written and said but for the ghost that follows me around. What matters most finds us when we are open, the way a flower opens up for the Sun I write because I don\u27t have a choice, the way Alice had to go through Wonderland before she could get out. What is left, having left Wonderland? But, wonder of course. Here is absolute necessity because \u27Writing, I feel, is an art, and artists, I feel, are human beings\u27 (e.e. Cummings). The blob, you see. Simultaneously, a giant sphere, all parts working at once. Nothing is fully separate. Don\u27t believe me? Neither do the bugs. Life is very serious, and strange, and funny. Go ask Alice. Because guess what, the bugs don\u27t believe her either; Let my truth be your truth, and then change it somewhere in the process, wherever you see fit. Things lie deeply wedged in the world, and none of me knows quite what the world is, just that it is. Just as you must be true, I have given myself to the world that wants me (as there are more than one when you take into account the wetness of imagination), because if I don\u27t, then what\u27s this life anyway? What\u27s this world? Peter Gabriel says, \u27If you don\u27t get given you learn to take, and I will take you.\u27 You ought to say this, Too \u27Tis better to be given over to something than to force myself into a mold because I want to fit somewhere amongst the made constructions that hold life together. I am only what I am in this poetry. It is about many things, this book.*; (Abstract shortened by UMI.)

The Complex X-ray Spectrum of the Sefyert 1.5 Source NGC 6860

The X-ray spectrum of the Seyfert 1.5 source NGC 6860 is among the most complex of the sources detected in the Swift Burst Alert Telescope all-sky survey. A short XMM-Newton follow-up observation of the source revealed a flat spectrum both above and below 2 keV. To uncover the complexity of the source, in this paper we analyze both a 40 ks Suzaku and a 100 ks XMM-Newton observation of NGC 6860. While the spectral state of the source changed between the newer observations presented here and the earlier short XMM-Newton spectrum - showing a higher flux and steeper power law component - the spectrum of NGC 6860 is still complex with clearly detected warm absorption signatures. We find that a two component warm ionized absorber is present in the soft spectrum, with column densities of about 10^20 and 10^21 cm$^-2, ionization parameters of xi = 180 and 45 ergs cm s^-1, and outflow velocities for each component in the range of 0-300 km s^-1. Additionally, in the hard spectrum we find a broad (approx 11000 km s^-1) Fe K-alpha emission line, redshifted by approx 2800 km s^-1.Comment: 35 pages, 9 figures, Accepted to Ap

The Swift BAT-detected Seyfert 1 Galaxies: X-ray Broadband Properties and Warm Absorbers

We present results from an analysis of the broad-band, 0.3-195 keV, X-ray spectra of 48 Seyfert 1-1.5 sources detected in the very hard X-rays with the Swift Burst Alert Telescope (BAT). This sample is selected in an all-sky survey conducted in the 14-195 keV band. Therefore, our sources are largely unbiased towards both obscuration and host galaxy properties. Our detailed and uniform model fits to Suzaku/BAT and XMM-Newton/BAT spectra include the neutral absorption, direct power-law, reflected emission, soft excess, warm absorption, and narrow Fe K-alpha emission properties for the entire sample. We significantly detect O VII and O VIII edges in 52% of our sample. The strength of these detections are strongly correlated with the neutral column density measured in the spectrum. Among the strongest detections, X-ray grating and UV observations, where available, indicate outflowing material. The ionized column densities of sources with O VII and O VIII detections are clustered in a narrow range with N$_{\rm warm} \sim 10^{21}$\,cm$^{-2}$, while sources without strong detections have column densities of ionized gas an order of magnitude lower. Therefore, we note that sources without strong detections likely have warm ionized outflows present but at low column densities that are not easily probed with current X-ray observations. Sources with strong complex absorption have a strong soft excess, which may or may not be due to difficulties in modeling the complex spectra of these sources. Still, the detection of a flat Gamma ~ 1 and a strong soft excess may allow us to infer the presence of strong absorption in low signal-to-noise AGN spectra. Additionally, we include a useful correction from the Swift BAT luminosity to bolometric luminosity, based on a comparison of our spectral fitting results with published spectral energy distribution fits from 33 of our sources.Comment: 60 pages (pre-print format), 14 figures, accepted to Ap

Chapter 08: Conclusions and Recommendations

Here we review brief summaries by chapter and then derive some integrated conclusions across chapters. Recommendations are presented with respect to further research, outreach and policy consideration. Because several years have passed between the end of our field work and publication of this synthesis volume, we end with an epilogue that highlights changes and key events that happened at San José Llanga (SJL) and with collaborating institutions in Bolivia between 1996-9.https://digitalcommons.usu.edu/sustaining_agropastoralism/1007/thumbnail.jp

Psychiatric symptoms and moral injury among US healthcare workers in the COVID-19 era

Background Emerging cross-sectional data indicate that healthcare workers (HCWs) in the COVID-19 era face particular mental health risks. Moral injury – a betrayal of one’s values and beliefs, is a potential concern for HCWs who witness the devastating impact of acute COVID-19 illness while too often feeling helpless to respond. This study longitudinally examined rates of depression, generalized anxiety disorder (GAD), posttraumatic stress disorder (PTSD), and moral injury among United States HCWs in the COVID-19 era. We anticipated finding high levels of clinical symptoms and moral injury that would remain stable over time. We also expected to find positive correlations between clinical symptoms and moral injury. Methods This three-wave study assessed clinical symptoms and moral injury among 350 HCWs at baseline, 30, and 90 days between September and December 2020. Anxiety, depression, PTSD, and moral injury were measured using the Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), Primary Care PTSD Screen (PC-PTSD), and Moral Injury Events Scale (MIES). Results Of the 350 HCWs, 72% reported probable anxiety, depression, and/or PTSD disorders at baseline, 62% at day 30, and 64% at day 90. High level of moral injury was associated with a range of psychopathology including suicidal ideation, especially among healthcare workers self-reporting COVID-19 exposure. Conclusions Findings demonstrate broad, persisting, and diverse mental health consequences of the COVID-19 pandemic among United States HCWs. This study is the first to longitudinally examine the relationships between moral injury and psychopathology among HCWs, emphasizing the need to increase HCWs’ access to mental healthcare

Tissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial

AbstractRegular aspirin use reduces colon adenoma and carcinoma incidence. UDP-glucuronosyltransferases (UGT) are involved in aspirin metabolism and clearance, and variant alleles in UGT1A6 have been shown to alter salicylic acid metabolism and risk of colon neoplasia. In a randomized, cross-over, placebo-controlled trial of 44 healthy men and women, homozygous for UGT1A6*1 or UGT1A6*2, we explored differences between global epithelial and stromal expression, using Affymetrix U133+2.0 microarrays and tested effects of 60-day aspirin supplementation (325mg/d) on epithelial and stromal gene expression and colon prostaglandin E2 (PGE2) levels. We conducted a comprehensive study of differential gene expression between normal human colonic epithelium and stroma from healthy individuals. Although no statistically significant differences in gene expression were observed in response to aspirin or UGT1A6 genotype, we have identified the genes uniquely and reproducibly expressed in each tissue type and have analyzed the biologic processes they represent. Here we describe in detail how the data, deposited in the Gene Expression Omnibus (GEO) – accession number GSE71571 – was generated including the basic analysis as contained in the manuscript published in BMC Medical Genetics with the PMID 25927723 (Thomas et al., 2015 [9])

Connecting on Climate: A Guide to Effective Climate Change Communication

Climate change is not a new issue, but the need for meaningful and sustainable solutions is more urgent than ever. Climate communicators and mainstream leaders are still grappling with how to help Americans find meaningful, actionable paths forward and overcome the social, political, psychological, and emotional barriers that have hindered progress on climate solutions. To connect with audiences and unlock success in climate change communication, communicators need to shift their approach. Communicators need to go beyond simply providing people with the facts about climate change. They need to connect with people’s values and worldviews and put solutions at the forefront to make climate change personally relevant to Americans and those they love. With this guide, we have brought together both researchers and practitioners to consolidate the best insights and evidence about how to communicate effectively about climate change. We have combined research from the Center for Research on Environmental Decisions (CRED) at The Earth Institute, Columbia University; ecoAmerica; and other institutions with insights that ecoAmerica has gleaned from communicating about climate change and other environmental issues with mainstream Americans and their leaders. This guide presents information in a digestible, actionable form to enable communicators to “up their game” when engaging Americans on climate solutions of all types and scales

Identification of a Novel TGFβ/PKA Signaling Transduceome in Mediating Control of Cell Survival and Metastasis in Colon Cancer

Understanding drivers for metastasis in human cancer is important for potential development of therapies to treat metastases. The role of loss of TGFβ tumor suppressor activities in the metastatic process is essentially unknown.Utilizing in vitro and in vivo techniques, we have shown that loss of TGFβ tumor suppressor signaling is necessary to allow the last step of the metastatic process - colonization of the metastatic site. This work demonstrates for the first time that TGFβ receptor reconstitution leads to decreased metastatic colonization. Moreover, we have identified a novel TGFβ/PKA tumor suppressor pathway that acts directly on a known cell survival mechanism that responds to stress with the survivin/XIAP dependent inhibition of caspases that effect apoptosis. The linkage between the TGFβ/PKA transduceome signaling and control of metastasis through induction of cell death was shown by TGFβ receptor restoration with reactivation of the TGFβ/PKA pathway in receptor deficient metastatic colon cancer cells leading to control of aberrant cell survival.This work impacts our understanding of the possible mechanisms that are critical to the growth and maintenance of metastases as well as understanding of a novel TGFβ function as a metastatic suppressor. These results raise the possibility that regeneration of attenuated TGFβ signaling would be an effective target in the treatment of metastasis. Our work indicates the clinical potential for developing anti-metastasis therapy based on inhibition of this very important aberrant cell survival mechanism by the multifaceted TGFβ/PKA transduceome induced pathway. Development of effective treatments for metastatic disease is a pressing need since metastases are the major cause of death in solid tumors