Welcome to FASEB BioAdvances, the new open access journal by the Federation of American Societies for Experimental Biology (FASEB)

Although the idea of starting an open access journal had been discussed for years, the need for it became clear at FASEB's Publications and Communications Committee meeting in March 2016. The increased uptake of open access publishing in The FASEB Journal made it evident that there was strong and growing demand for this type of publishing among authors and their funders, and that this demand was likely not being met fully by The FASEB Journal's hybrid open access approach. Furthermore, given The FASEB Journal's selectivity based on publishing priority, not all studies will be published, regardless of how well the experiments are designed and conducted. This leaves a number of authors and potential authors seeking to publish multi/transdisciplinary work with FASEB for whom The FASEB Journal may not be the best fit. Finally, as the focus toward reproducibility intensifies, FASEB wanted to provide a venue where scientists can publish reports covering their ability (or inability) to replicate published experiments. Because these reports lack the novelty of new experimentation, they would likely never be published in The FASEB Journal, despite their critical importance to working scientists

The Correlation of Configuration of Optically Active Nor-pseudo-ephedrine and Alanine

D-Nor - pseudo- ephedrine was prepare d from N-phthaloyl-D-alanyl chloride through the intermediate D-a-phthalimido-propiophenone which was reduced with aluminum isopropoxide to the appropriate carbinol. L-Nor- pseudo-ephedrine was prepared in the same way from L-alanine. The configurational correlation between D-nor-pseudo-ephedrine and D-alanine a nd L-nor- pseudo-ephedrine and L-alanine was established. The configurational relation of C(2) atom of chloramphenicol and D-(-)-nor - pseudo - ephedrine was thus established since chloramphenicol was previously synthetized from D-serine

Synthesis of Some Quaternary Ammonium Salts Derived from Esters of Dihydromuconic Acid

Choline esters of dicarboxylic acids, because of their use as short acting neuromuscular blocking agents, have been in the last few years the subject of wide inivestigations. Bovet and collaborators have studied the relationship between the chain length of ailiphatic dicarboxylic acids and the curariform activity. They found that the activity increases if the length of the chain increases from oxalic to succinic acid, but further lengthening of the chain decreases the paralysing activity. They also claimed that the double bond had no significant influence on the curariform activity

Synthesis of β-Alethine and Analogues

In the past few years many papers have appeared relating to the problem of the synthesis of B-alethine an intermediate in the synthesis of panthetine. A more recent publication on the synthesis of B -alethine and analogues has prompted us to publish our own results on the synthesis of B -alethine and analogues derived from glycine and O-methyl-DL-serine

Synthesis of β,β\u27-(4,4\u27-Diphenyl ether)-dialanine

β,β\u27-(4,4\u27-Diphenyl ether)-dialanine has been prepared by the use of Erlenmeyer reaction starting from 4,4\u27-diformyldiphenylether

Synthesis of β,β\u27-(4,4\u27-Diphenyl ether)-dialanine

β,β\u27-(4,4\u27-Diphenyl ether)-dialanine has been prepared by the use of Erlenmeyer reaction starting from 4,4\u27-diformyldiphenylether

New Method for the Preparation of Arylsulphonylureas

The discovery of the potent hypoglycemic action of N-butyl-N\u27-sulphanylurea (Carbutamide, I)1 stimulated wide investigations of the chemically related compounds2 but most of them were toxic for human use. However, N-butyl-N\u27-p-toluenesulphonylurea (Tolbutamide, II) and N-propyl-N\u27-pchlorobenzenesulphonylurea (Chlorpropamide, III) have been widely used without toxic side effects in the treatment of mild diabetes mellitus of the adult type

Synthetic Studies in the Sulphonamide Series. II. Application of the Wolff Rearrangement to the Preparation of N-Acylsulphonamides

The Wolff rearrarigement of a-diazoketones was performed in the presence of sodium sulphonamides and the corresponding N-acylsulphonamides were obtained. When tested on rats, these compounds showed a very strong diuretic activity

Synthesis of Bis(/beta;-chloroethyl)-amides and Bis-ethylenimides of Some Dicarboxylic Acids

Bis(B-chloroethyl)-amides and bis-ethylenimides of muconic acid , dihydromuconic acid, 4,4 \u27 -dicarboxy-diphenylether and 4 ,4\u27 bis(carboxymethyl)-diphenylether were prepared as possible cytotoxic agents

Synthesis of β-Alethine and Analogues

In the past few years many papers have appeared relating to the problem of the synthesis of B-alethine an intermediate in the synthesis of panthetine. A more recent publication on the synthesis of B -alethine and analogues has prompted us to publish our own results on the synthesis of B -alethine and analogues derived from glycine and O-methyl-DL-serine