Curling i samtidens sken En djupdykning i marknadsföring och konsumentgrupper

Curling härstammar från Skottland och spåras tillbaka till 1500-talet. Curlingen kom till Sverige i mitten av 1800-talet och Svenska Curlingförbundet bildades i början av 1900-talet. Curlingsporten , som traditionellt förknippas med äldre vuxna, ölmagar, cigarettrökning och sällskaplighet, har gått in i en tid där dominerande diskurser främjar en strikt diet, lite alkohol, ingen rökning och konstant fysisk aktivitet som ett sätt att "åldras väl " inom sporten. Marknadsföring inom curling har blivit ett stort problem idag. Det här är en sport som ofta är okänd för allmänheten, men det finns många som älskar att spela det. Vidare kan man även se att bristen på information som ges till intresserade curlingfans är ett problem.  Syftet med studien är att undersöka hur curlingen ser ut i dagsläget. Mer specifikt hur marknadsföringen ser ut, men även vilka konsumentgrupper som i dagsläget förknippas med eller utövar sporten.  Resultatet i studien visar att det finns utvecklingsmöjligheter när det kommer till marknadsföring och konsumentgrupper inom curling. Dels arbete med sociala medier och vad som ska visas på dessa men även hur man ska locka fler ungdomar till sporten då den domineras av äldre individer.

Curling i samtidens sken En djupdykning i marknadsföring och konsumentgrupper

Curling härstammar från Skottland och spåras tillbaka till 1500-talet. Curlingen kom till Sverige i mitten av 1800-talet och Svenska Curlingförbundet bildades i början av 1900-talet. Curlingsporten , som traditionellt förknippas med äldre vuxna, ölmagar, cigarettrökning och sällskaplighet, har gått in i en tid där dominerande diskurser främjar en strikt diet, lite alkohol, ingen rökning och konstant fysisk aktivitet som ett sätt att "åldras väl " inom sporten. Marknadsföring inom curling har blivit ett stort problem idag. Det här är en sport som ofta är okänd för allmänheten, men det finns många som älskar att spela det. Vidare kan man även se att bristen på information som ges till intresserade curlingfans är ett problem.  Syftet med studien är att undersöka hur curlingen ser ut i dagsläget. Mer specifikt hur marknadsföringen ser ut, men även vilka konsumentgrupper som i dagsläget förknippas med eller utövar sporten.  Resultatet i studien visar att det finns utvecklingsmöjligheter när det kommer till marknadsföring och konsumentgrupper inom curling. Dels arbete med sociala medier och vad som ska visas på dessa men även hur man ska locka fler ungdomar till sporten då den domineras av äldre individer.

Improved Scaffold Hopping in Ligand-based Virtual Screening Using Neural Representation Learning

Deep learning has demonstrated significant potential in advancing state of the art in many problem domains, especially those benefiting from automated feature extraction. Yet the methodology has seen limited adoption in the field of ligand-based virtual screening (LBVS), as traditional approaches typically require large, target-specific training sets, which limits their value in most prospective applications. Here, we report the development of a neural network architecture, and a learning framework designed to yield a generally applicable tool for LBVS. Our approach uses the molecular graph as input, and involves learning a representation that places compounds of similar biological profiles in close proximity within a hyperdimensional feature space; this is achieved by simultaneously leveraging historical screening data against a multitude of targets during training. Cosine distance between molecules in this space becomes a general similarity metric, and can readily be used to rank order database compounds in LBVS workflows. We demonstrate the resulting model generalizes exceptionally well to compounds and targets not used in its training. In three commonly employed LBVS benchmarks, our method outperforms popular fingerprinting algorithms without the need for any target-specific training. Moreover, we show the learned representation yields superior performance in scaffold hopping tasks, and is largely orthogonal to existing fingerprints. Summarily, we have developed and validated a framework for learning a molecular representation that is applicable to LBVS in a target-agnostic fashion, with as few as one query compound. Our approach can also enable organizations to generate additional value from large screening data repositories, and to this end we are making its implementation freely available at https://github.com/totient-bio/gatnn-vs</pre

To ventilate or not to ventilate during bystander CPR — A EuReCa TWO analysis

Background: Survival after out-of-hospital cardiac arrest (OHCA) is still low. For every minute without resuscitation the likelihood of survival decreases. One critical step is initiation of immediate, high quality cardiopulmonary resuscitation (CPR). The aim of this subgroup analysis of data collected for the European Registry of Cardiac Arrest Study number 2 (EuReCa TWO) was to investigate the association between OHCA survival and two types of bystander CPR namely: chest compression only CPR (CConly) and CPR with chest compressions and ventilations (FullCPR). Method: In this subgroup analysis of EuReCa TWO, all patients who received bystander CPR were included. Outcomes were return of spontaneous circulation and survival to 30-days or hospital discharge. A multilevel binary logistic regression analysis with survival as the dependent variable was performed. Results: A total of 5884 patients were included in the analysis, varying between countries from 21 to 1444. Survival was 320 (8%) in the CConly group and 174 (13%) in the FullCPR group. After adjustment for age, sex, location, rhythm, cause, time to scene, witnessed collapse and country, patients who received FullCPR had a significantly higher survival rate when compared to those who received CConly (adjusted odds ration 1.46, 95% confidence interval 1.17–1.83). Conclusion: In this analysis, FullCPR was associated with higher survival compared to CConly. Guidelines should continue to emphasise the importance of compressions and ventilations during resuscitation for patients who suffer OHCA and CPR courses should continue to teach both

To ventilate or not to ventilate during bystander CPR : a EuReCa TWO analysis

Background: Survival after out-of-hospital cardiac arrest (OHCA) is still low. For every minute without resuscitation the likelihood of survival decreases. One critical step is initiation of immediate, high quality cardiopulmonary resuscitation (CPR). The aim of this subgroup analysis of data collected for the European Registry of Cardiac Arrest Study number 2 (EuReCa TWO) was to investigate the association between OHCA survival and two types of bystander CPR namely: chest compression only CPR (CConly) and CPR with chest compressions and ventilations (FullCPR). Method: In this subgroup analysis of EuReCa TWO, all patients who received bystander CPR were included. Outcomes were return of spontaneous circulation and survival to 30-days or hospital discharge. A multilevel binary logistic regression analysis with survival as the dependent variable was performed. Results: A total of 5884 patients were included in the analysis, varying between countries from 21 to 1444. Survival was 320 (8%) in the CConly group and 174 (13%) in the FullCPR group. After adjustment for age, sex, location, rhythm, cause, time to scene, witnessed collapse and country, patients who received FullCPR had a significantly higher survival rate when compared to those who received CConly (adjusted odds ration 1.46, 95% confidence interval 1.17–1.83). Conclusion: In this analysis, FullCPR was associated with higher survival compared to CConly. Guidelines should continue to emphasise the importance of compressions and ventilations during resuscitation for patients who suffer OHCA and CPR courses should continue to teach both