Physiological detection of water and nitrogen deprivation

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A multicentre, prospective, randomised controlled trial to assess the safety and effectiveness of cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction: the COOL AMI EU Pivotal

Despite primary PCI (PPCI), ST-elevation myocardial infarction (STEMI) can still result in large infarct size (IS). New technology with rapid intravascular cooling showed positive signals for reduction in IS in anterior STEMI.We investigated the effectiveness and safety of rapid systemic intravascular hypothermia as an adjunct to PPCI in conscious patients, with anterior STEMI, without cardiac arrest.Hypothermia was induced using the ZOLL® Proteus™ intravascular cooling system. After randomisation of 111 patients, 58 to hypothermia and 53 to control groups, the study was prematurely discontinued by the sponsor due to inconsistent patient logistics between the groups resulting in significantly longer total ischaemic delay in the hypothermia group (232 vs 188 minutes; p<0.001).There were no differences in angiographic features and PPCI result between the groups. Intravascular temperature at wire crossing was 33.3+0.9°C. Infarct size/left ventricular mass (IS/LV) by cardiac magnetic resonance (CMR) at day 4-6 was 21.3% in the hypothermia group and 20.0% in the control group (p=0.540). Major adverse cardiac events at 30 days increased non-significantly in the hypothermia group (8.6% vs 1.9%; p=0.117) while cardiogenic shock (10.3% vs 0%; p=0.028) and paroxysmal atrial fibrillation (43.1% vs 3.8%; p<0.001) were significantly more frequent in the hypothermia group.The ZOLL Proteus intravascular cooling system reduced temperature to 33.3°C before PPCI in patients with anterior STEMI. Due to inconsistent patient logistics between the groups, this hypothermia protocol resulted in a longer ischaemic delay, did not reduce IS/LV mass and was associated with increased adverse events

Klímaadaptációs és kockázatértékelési kézikönyv a Duna makrorégióra

In this paper we find the maximal order of an automorphism of a trigonal Riemann surface of genus g, g5. We find that this order is smaller for generic than for cyclic trigonal Riemann surfaces, showing that generic trigonal surfaces have “less symmetry” than cyclic trigonal surfaces. Finally we prove that the maximal order is attained for infinitely many genera in both the cyclic and the generic case.Original Publication:Antonio F. Costa and Milagros Izquierdo, Maximal order of automorphisms of trigonal Riemann surfaces, 2010, Journal of Algebra, (323), 1, 27-31.http://dx.doi.org/10.1016/j.jalgebra.2009.09.041Copyright: Elsevier Science B.V., Amsterdamhttp://www.elsevier.com

Novi i značajni podaci o biljkama, algama i gljivama iz JI Evrope i susednih regiona, 16

This paper presents new records and noteworthy data on the following taxa in SE Europe and adjacent regions: diatoms Discostella asterocostata and Stephanodiscus hantzschii f. tenuis, red alga Bangia atropurpúrea, green alga Ulvapilifera, saprotro-phic fungi Didymella vitalbina and Phragmotrichum rivoclarinum, mosses Buxbau-mia aphylla, Sphagnum divinum, and Tortella fasciculata, monocots Anacamptis x nicodemi, Epipactis palustris, Epipogium aphyllum, and Gymnadenia frivaldii and dicots Androsace lactea, Drosera rotundifolia, Potentilla montenegrina, and Tozzia alpina subsp. carpathica are given within SE Europe and adjacent regions.U radu su prikazani novi i značajni podaci sa područja JI Evrope i susednih regiona o sledećim taksonima: dijatomejskim algama Discostella asterocostata i Stephanodiscus hantzschii f. tenuis, crvenoj algi Bangia atropurpurea, zelenoj algi Ulva pilifera, saprofitskim gljivama Didymella vitalbina i Phragmotrichum rivoclarinum, mahovinama Buxbaumia aphylla, Sphagnum divinum i Tortella fascicu- lata, monokotilama Anacamptis × nicodemi, Epipactis palustris, Epipogium aphyllum i Gymnadenia frivaldii i dikotilama Androsace lactea, Drosera rotundifolia, Potentilla montenegrina i Tozzia alpina subsp. carpathica

Helical Chirality: a Link between Local Interactions and Global Topology in DNA

DNA supercoiling plays a major role in many cellular functions. The global DNA conformation is however intimately linked to local DNA-DNA interactions influencing both the physical properties and the biological functions of the supercoiled molecule. Juxtaposition of DNA double helices in ubiquitous crossover arrangements participates in multiple functions such as recombination, gene regulation and DNA packaging. However, little is currently known about how the structure and stability of direct DNA-DNA interactions influence the topological state of DNA. Here, a crystallographic analysis shows that due to the intrinsic helical chirality of DNA, crossovers of opposite handedness exhibit markedly different geometries. While right-handed crossovers are self-fitted by sequence-specific groove-backbone interaction and bridging Mg2+ sites, left-handed crossovers are juxtaposed by groove-groove interaction. Our previous calculations have shown that the different geometries result in differential stabilisation in solution, in the presence of divalent cations. The present study reveals that the various topological states of the cell are associated with different inter-segmental interactions. While the unstable left-handed crossovers are exclusively formed in negatively supercoiled DNA, stable right-handed crossovers constitute the local signature of an unusual topological state in the cell, such as the positively supercoiled or relaxed DNA. These findings not only provide a simple mechanism for locally sensing the DNA topology but also lead to the prediction that, due to their different tertiary intra-molecular interactions, supercoiled molecules of opposite signs must display markedly different physical properties. Sticky inter-segmental interactions in positively supercoiled or relaxed DNA are expected to greatly slow down the slithering dynamics of DNA. We therefore suggest that the intrinsic helical chirality of DNA may have oriented the early evolutionary choices for DNA topology

Words apart: Standardizing forestry terms and definitions across European biodiversity studies

Forest biodiversity studies conducted across Europe use a multitude of forestry terms, often inconsistently. This hinders the comparability across studies and makes the assessment of the impacts of forest management on biodiversity highly context-dependent. Recent attempts to standardize forestry and stand description terminology mostly used a top-down approach that did not account for the perspectives and approaches of forest biodiversity experts. This work aims to establish common standards for silvicultural and vegetation definitions, creating a shared conceptual framework for a consistent study on the effects of forest management on biodiversity. We have identified both strengths and weaknesses of the silvicultural and vegetation information provided in forest biodiversity studies. While quantitative data on forest biomass and dominant tree species are frequently included, information on silvicultural activities and vegetation composition is often lacking, shallow, or based on broad and heterogeneous classifications. We discuss the existing classifications and their use in European forest biodiversity studies through a novel bottom-up and top-driven review process, and ultimately propose a common framework. This will enhance the comparability of forest biodiversity studies in Europe, and puts the basis for effective implementation and monitoring of sustainable forest management policies. The standards here proposed are potentially adaptable and applicable to other geographical areas and could be extended to other forest interventions. Forest management Multi-taxon Terminology Silviculture Data harmonizationpublishedVersio