408 research outputs found
Are conservation actions reducing the threat to India's vulture populations?
Research Communications.-- et al.Veterinary use of the non-steroidal anti-inflammatory drug, diclofenac is responsible for the population collapse of resident vulture species in India. Conservation efforts, including a ban on veterinary diclofenac and the identification of a vulture-safe alternative (meloxicam), were introduced in 2006 in order to address the threat. Sampling of domesticated ungulate carcasses available to vultures in India was undertaken in three surveys prior to, around the time of, and 1-2 years after the ban in order to quantify the prevalence of diclofenac and meloxicam residues. A total of 1445, 1488 and 1251 liver tissue samples were collected from nine states and analysed with a validated LC-ESI/MS methodology. Overall diclofenac prevalence levels declined by almost a half over the three surveys, and there was an increase in meloxicam prevalence between the second and third surveys, although some states revealed little change. These surveys indicate that two of the key conservation actions to counter the threat faced by vultures - banning veterinary diclofenac and promoting meloxicam as a safe alternative - are beginning to take effect. However, because only a small proportion of diclofenac-contaminated carcasses is sufficient to cause vulture population declines, further efforts are needed to eliminate diclofenac from the food supply of India's vultures.The research was funded by the UK Governmentâs Darwin Initiative programme and by the
Royal Society for the Protection of Birds, UK.Peer Reviewe
Effects of Medication Therapy Management on Health Care Utilization in Medicare and Commercial Patients with Neurological Conditions at LVHN
Prevalence of liver fluke (Fasciola hepatica) in wild Red Deer (Cervus elaphus): coproantigen ELISA is a practicable alternative to faecal egg counting for surveillance in remote populations
Red deer (Cervus elaphus) are hosts of liver fluke (Fasciola hepatica); yet, prevalence is rarely quantified in wild populations. Testing fresh samples from remote regions by faecal examination (FE) can be logistically challenging; hence, we appraise frozen storage and the use of a coproantigen ELISA (cELISA) for F. hepatica surveillance. We also present cELISA surveillance data for red deer from the Highlands of Scotland. Diagnoses in faecal samples (207 frozen, 146 fresh) were compared using a cELISA and by FE. For each storage method (frozen or fresh), agreement between the two diagnostics was estimated at individual and population levels, where population prevalence was stratified into cohorts (e.g., by sampling location). To approximate sensitivity and specificity, 65 post-slaughter whole liver examinations were used as a reference. At the individual level, FE and cELISA diagnoses agreed moderately (Îșfrozen = 0.46; Îșfresh = 0.51), a likely reflection of their underlying principles. At the population level, FE and cELISA cohort prevalence correlated strongly (Pearsonâs R = 0.89, p < 0.0001), reflecting good agreement on relative differences between cohort prevalence. In frozen samples, prevalence by cELISA exceeded FE overall (42.8% vs. 25.8%) and in 9/12 cohorts, alluding to differences in sensitivity; though, in fresh samples, no significant difference was found. In 959 deer tested by cELISA across the Scottish Highlands, infection prevalence ranged from 9.6% to 53% by sampling location. We highlight two key advantages of cELISA over FE: i) the ability to store samples long term (frozen) without apparent loss in diagnostic power; and ii) reduced labour and the ability to process large batches. Further evaluation of cELISA sensitivity in red deer, where a range of fluke burdens can be obtained, is desirable. In the interim, the cELISA is a practicable diagnostic for F. hepatica surveillance in red deer, and its application here has revealed considerable geographic, temporal, sex and age related differences in F. hepatica prevalence in wild Scottish Highland red deer
Using Pedometer Step-Count Goals to Promote Physical Activity in Cardiac Rehabilitation: A Feasibility Study of a Controlled Trial
Utilizing low-cost natural waste for the removal of pharmaceuticals from water:Mechanisms, isotherms and kinetics at low concentrations
Detection and drivers of exposure and effects of pharmaceuticals in higher vertebrates
Pharmaceuticals are highly bioactive compounds now known to be widespread environmental contaminants. However, research regarding exposure and possible effects in non-target higher vertebrate wildlife remains scarce. The fate and behaviour of most pharmaceuticals entering our environment via numerous pathways remain poorly characterized, and hence our conception and understanding of the risks posed to wild animals is equally constrained. The recent decimation of Asian vulture populations owing to a pharmaceutical (diclofenac) offers a notable example, because the exposure route (livestock carcasses) and the acute toxicity observed were completely unexpected. This case not only highlights the need for further research, but also the wider requirement for more considered and comprehensive âecopharmacovigilanceâ. We discuss known and potential high risk sources and pathways in terrestrial and freshwater ecosystems where pharmaceutical exposure in higher vertebrate wildlife, principally birds and mammals, may occur. We examine whether approaches taken within existing surveillance schemes (that commonly target established classes of persistent or bioaccumulative contaminants) and the risk assessment approaches currently used for pesticides are relevant to pharmaceuticals, and we highlight where new approaches may be required to assess pharmaceutical-related risk
A SPE-HPLC-MS/MS method for the simultaneous determination of prioritised pharmaceuticals and EDCs with high environmental risk potential in freshwater
Reply to comments on âLow-cost chitosan-calcite adsorbent development for potential phosphate removal and recovery from wastewater effluentâ by Pap et al. [Water research 173 (2020) 115573]
Identifying seaweed consumption by sheep using isotope analysis of their bones and teeth : Modern reference ÎŽ13C and ÎŽ15N values and their archaeological implications
This research was funded by the British Natural Environment Research Council (NERC; NER/B/S/2003/00223) and the European Social Fund and Scottish Funding Council as part of Developing Scotlandâs Workforce in the Scotland 2014-2020 European Structural and Investment Fund Programme. Stable isotope values in tooth enamel were measured at the SSMIM (Paris, MNHN) with technical support of JoĂ«l Ughetto. Modern sheep mandibles and/or information on sheep herding practices on Orkney were kindly provided by Robert Mainland (Rousay), Linda Haganand Una Gordon (Holm of Aikerness), Billy Muir, Dr Kevin Woodbridge and the North Ronaldsay Sheep Court (North Ronaldsay). We would like to thank Anne Brundle, Tankerness House Museum, Orkney (Point of Cott), Dr Colleen Batey, University of Glasgow (Earlâs Bu) and ProfJane Downes and Nick Card, Orkney College, UHI (Mine Howe) for providing access to the archaeological mandibles. The authors would also like to thank Jane Outram and Mandy Jay for assistance in preparation and isotopic measurement of the vegetation samples, which were kindly collected by Robert Craigie, and Karen Chapman for preparing the mandibles. Lastly, the authors are also grateful for the constructive comments of the editors and anonymous reviewers.Peer reviewedPostprin
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Written submission from the School of Law, Politics and Sociology, University of Sussex (OEU0007)to the Women and equalities Committee inquiry: ensuring strong equalities legislation after EU exit
Undoubtedly, the UKâs equalities legislation has become stronger in recent years providing important protection for people who experience discrimination. Nevertheless, this has happened in the context of widening economic inequality, cuts in public services and restrictions on access to justice â all of which make it harder for victims of discrimination to realise the rights that exist on paper. If the UK leaves the EU, the next few years will be a period of great political, economic and social instability when it will be vital to ensure that protection against discrimination is strengthened not weakened and that a culture of support for equality and human rights is promoted throughout the UK. The rights that must be protected benefit everyone in the UK, not only supporting marginalised people and victims of discrimination but also making workplaces fairer for all and underpinning the legitimacy of our democratic institutions
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