Toral Algebraic Sets and Function Theory on Polydisks

A toral algebraic set $A$ is an algebraic set in \C^n whose intersection with \T^n is sufficiently large to determine the holomorphic functions on $A$. We develop the theory of these sets, and give a number of applications to function theory in several variables and operator theoretic model theory. In particular, we show that the uniqueness set for an extremal Pick problem on the bidisk is a toral algebraic set, that rational inner functions have zero sets whose irreducible components are not toral, and that the model theory for a commuting pair of contractions with finite defect lives naturally on a toral algebraic set

An automated ETL for online datasets

While using online datasets for machine learning is commonplace today, the quality of these datasets impacts on the performance of prediction algorithms. One method for improving the semantics of new data sources is to map these sources to a common data model or ontology. While semantic and structural heterogeneities must still be resolved, this provides a well established approach to providing clean datasets, suitable for machine learning and analysis. However, when there is a requirement for a close to real time usage of online data, a method for dynamic Extract-Transform-Load of new sources data must be developed. In this work, we present a framework for integrating online and enterprise data sources, in close to real time, to provide datasets for machine learning and predictive algorithms. An exhaustive evaluation compares a human built data transformation process with our system’s machine generated ETL process, with very favourable results, illustrating the value and impact of an automated approach

The Semantic Automated Discovery and Integration (SADI) Web service Design-Pattern, API and Reference Implementation

Background. 
The complexity and inter-related nature of biological data poses a difficult challenge for data and tool integration. There has been a proliferation of interoperability standards and projects over the past decade, none of which has been widely adopted by the bioinformatics community. Recent attempts have focused on the use of semantics to assist integration, and Semantic Web technologies are being welcomed by this community.

Description. 
SADI – Semantic Automated Discovery and Integration – is a lightweight set of fully standards-compliant Semantic Web service design patterns that simplify the publication of services of the type commonly found in bioinformatics and other scientific domains. Using Semantic Web technologies at every level of the Web services “stack”, SADI services consume and produce instances of OWL Classes following a small number of very straightforward best-practices. In addition, we provide codebases that support these best-practices, and plug-in tools to popular developer and client software that dramatically simplify deployment of services by providers, and the discovery and utilization of those services by their consumers.

Conclusions.
SADI Services are fully compliant with, and utilize only foundational Web standards; are simple to create and maintain for service providers; and can be discovered and utilized in a very intuitive way by biologist end-users. In addition, the SADI design patterns significantly improve the ability of software to automatically discover appropriate services based on user-needs, and automatically chain these into complex analytical workflows. We show that, when resources are exposed through SADI, data compliant with a given ontological model can be automatically gathered, or generated, from these distributed, non-coordinating resources - a behavior we have not observed in any other Semantic system. Finally, we show that, using SADI, data dynamically generated from Web services can be explored in a manner very similar to data housed in static triple-stores, thus facilitating the intersection of Web services and Semantic Web technologies

Peeling Back the Onion of Cyber Espionage after Tallinn 2.0

Tallinn 2.0 represents an important advancement in the understanding of international law’s application to cyber operations below the threshold of force. Its provisions on cyber espionage will be instrumental to states in grappling with complex legal problems in the area of digital spying. The law of cyber espionage as outlined by Tallinn 2.0, however, is substantially based on rules that have evolved outside of the digital context, and there exist serious ambiguities and limitations in its framework. This Article will explore gaps in the legal structure and consider future options available to states in light of this underlying mismatch

An automated ETL for online datasets

While using online datasets for machine learning is commonplace today, the quality of these datasets impacts on the performance of prediction algorithms. One method for improving the semantics of new data sources is to map these sources to a common data model or ontology. While semantic and structural heterogeneities must still be resolved, this provides a well established approach to providing clean datasets, suitable for machine learning and analysis. However, when there is a requirement for a close to real time usage of online data, a method for dynamic Extract-Transform-Load of new sources data must be developed. In this work, we present a framework for integrating online and enterprise data sources, in close to real time, to provide datasets for machine learning and predictive algorithms. An exhaustive evaluation compares a human built data transformation process with our system’s machine generated ETL process, with very favourable results, illustrating the value and impact of an automated approach

An automated ETL for online datasets

While using online datasets for machine learning is commonplace today, the quality of these datasets impacts on the performance of prediction algorithms. One method for improving the semantics of new data sources is to map these sources to a common data model or ontology. While semantic and structural heterogeneities must still be resolved, this provides a well established approach to providing clean datasets, suitable for machine learning and analysis. However, when there is a requirement for a close to real time usage of online data, a method for dynamic Extract-Transform-Load of new sources data must be developed. In this work, we present a framework for integrating online and enterprise data sources, in close to real time, to provide datasets for machine learning and predictive algorithms. An exhaustive evaluation compares a human built data transformation process with our system’s machine generated ETL process, with very favourable results, illustrating the value and impact of an automated approach

Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits

Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD). In PD, motor deficits correlate with the emergence of exaggerated beta frequency (15-30 Hz) oscillations throughout the CBT network. However, little is known about how specific cell types within individual CBT brain regions support the generation, propagation, and interaction of oscillatory dynamics throughout the CBT circuit or how specific oscillatory dynamics are related to motor function. Here, we investigated the role of striatal cholinergic interneurons (SChIs) in generating beta and gamma oscillations in cortical-striatal circuits and in influencing movement behavior. We found that selective stimulation of SChIs via optogenetics in normal mice robustly and reversibly amplified beta and gamma oscillations that are supported by distinct mechanisms within striatal-cortical circuits. Whereas beta oscillations are supported robustly in the striatum and all layers of primary motor cortex (M1) through a muscarinic-receptor mediated mechanism, gamma oscillations are largely restricted to the striatum and the deeper layers of M1. Finally, SChI activation led to parkinsonian-like motor deficits in otherwise normal mice. These results highlight the important role of striatal cholinergic interneurons in supporting oscillations in the CBT network that are closely related to movement and parkinsonian motor symptoms.DP2 NS082126 - NINDS NIH HHS; R01 NS081716 - NINDS NIH HHS; R21 NS078660 - NINDS NIH HHShttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896681/Published versio