HUMAN CARDIOVASCULAR RESPONSES TO ARTIFICIAL GRAVITY VARIABLES: GROUND-BASED EXPERIMENTATION FOR SPACEFLIGHT IMPLEMENTATION

One countermeasure to cardiovascular spaceflight deconditioning being tested is the application of intermittent artificial gravity provided by centripetal acceleration of a human via centrifuge. However, artificial gravity protocols have not been optimized for the cardiovascular system, or any other physiological system for that matter. Before artificial gravity protocols can be optimized for the cardiovascular system, cardiovascular responses to the variables of artificial gravity need to be quantified. The research presented in this document is intended to determine how the artificial gravity variables, radius (gravity gradient) and lower limb exercise, affect cardiovascular responses during centrifugation. Net fluid (blood) shifts between body segments (thorax, abdomen, upper leg, lower leg) will be analyzed to assess the cardiovascular responses to these variables of artificial gravity, as well as to begin to understand potential mechanism(s) underlying the beneficial orthostatic tolerance response resulting from artificial gravity training. Methods: Twelve healthy males experienced the following centrifuge protocols. Protocol A: After 10 minutes of supine control, the subjects were exposed to rotational 1 Gz at radius of rotation 8.36 ft (2.54 m) for 2 minutes followed by 20 minutes alternating between 1 and 1.25 Gz. Protocol B: Same as A, but lower limb exercise (70% V02max) preceded ramps to 1.25 Gz. Protocol C: Same as A but radius of rotation 27.36 ft (8.33 m). Results: While long radius without exercise presented an increased challenge for the cardiovascular system compared to short radius without exercise, it is likely at the expense of more blood “pooling” in the abdominal region. Whereas short radius with exercise provided a significant response compared to short radius without exercise. More fluid loss occurred from the thorax and with the increased fluid loss from the thorax blood did not “pool” in the abdominal region but instead was essentially “mobilized” to the upper and lower leg. The exercise fluid shift profile presented in this document is applicable to not only artificial gravity protocol design but also proposes a mechanistic reason as to why certain artificial gravity protocols are more effective than others in increasing orthostatic tolerance

Investment in Sustainable Development: A UK Perspective on the Business and Academic Challenges

There are many legislative, stakeholder and supply chain pressures on business to be more ‘sustainable’. Universities have recognised the need for graduate knowledge and understanding of sustainable development issues. Many businesses and universities have responded and introduced Sustainable Development models into their operations with much of the current effort directed at climate change. However, as the current worldwide financial crisis slowly improves, the expectations upon how businesses operate and behave are changing. It will require improved transparency and relationships with all stakeholders, which is the essence of sustainable development. The challenges and opportunities for both business and universities are to understand the requirements of sustainable development and the transformation that is required. They should ensure that knowledge is embedded within the culture of the organisation and wider society in order to achieve a sustainable future

Assessment of pain in older people : where are we now and what needs to be done?

The purpose of this paper is to present the findings of a review of the literature into pain and older people. The funded study was part of the development of an annotated bibliography published in August 2005. The review included all major databases and involved the collection of 214 papers between the dates of 1995 and 2005. The papers were divided into several major themes, which include experiences, management (pharmacological and non-pharmacological), assessment, and attitudes. Within this paper, the results of the review into pain assessment will be discussed, which includes 42 of the collected papers. The other sections will be published later. The paper will discuss issues pertaining to the development of specific tools for older people, a discussion of tools already available, comparisons of staff versus older people’s perceptions of pain scales, and articles with cognitive impairment as a focus. Recommendations for further study are made.University of Sheffiel

Assessment of Pain in adults with cognitive impairment : a review of the tools

The aim of this paper is to discuss the results of a review into the literature related to chronic pain and the older adult. Several themes within the review have been identified and reported elsewhere and the final report has been published by the University of Sheffield in the form of an annotated bibliography. This report focuses upon the findings of the in relation to the assessment of pain in the adult with cognitive impairment. Issues surrounding assessment in the non-cognitively impaired older adult have also been reported elsewhere. For this paper nine studies will be discussed which report the development and testing of pain assessment scales the focus of which is upon behavioural indicators of pain. Some scales have been omitted from the review and the rationale for this decision will be discussed. Each of the selected scales will be discussed and the authors will make recommendations for both clinical practice and for future research based upon the validity, reliability and user friendliness of the scales. From the paper it can be concluded that the Abbey, DOLOPLUS-2 and PACSLAC appear to be the most reliable and valid and in terms of the “user friendliness” would be appropriate to explore further. Recommendations are made for further multi-centre evaluation of these scales.University of Sheffiel

Teacher Perceptions of an Online Extensive Reading Platform

Extensive reading (ER) has been shown to have a number of positive effects on learning a foreign language. Improvements in vocabulary size, reading fluency and comprehension, and grammatical accuracy are just some of the outcomes of extensive reading programs. Since 2011, extensive reading at Sojo University has been carried out through the use of graded readers, typically in the form of physical books made available to students either in class or through the Self-Access Learning Center (SALC). Recently, the popularity of reading texts in digital format has increased with the ubiquitous ownership of portable devices such as smartphones, tablets, and lightweight laptops. In April 2018, all second-year students at Sojo University were required to purchase a subscription to a website known as Xreading (www.xreading.com), which offers hundreds of graded readers in digital format. This study examines teacher perceptions of the platform. A total of nine teachers participated in the study, including the authors of the paper, and the results appear to indicate that teachers feel extensive reading in general is a worthwhile activity but difficult to implement in this context. Results also show that teachers feel the online platform, Xreading, needs to improve in several areas before providing a significant advantage over physical books

Using Teacher Interviews as a Tool for Motivating Students

The Sojo International Leaning Center (SILC) is the teaching and research center where English classes are held at Sojo University. This article reports on a SILC Pioneers’ Educational Chat (SPEC) conducted during the 2020-21 academic year. The purpose of this particular SPEC was to introduce SILC teachers to an activity that is used during the Self-Directed Learning (SDL) unit in the curriculum for second-year students. During the SDL unit students are taught how to manage their own learning by making goals and creating learning plans to achieve these goals. Students need a sufficient amount of motivation to accomplish this. One possible source of motivation could come from the use of role models. At the beginning of the SDL unit students complete an activity in which they watch a video of a Japanese professor speaking English and giving advice to students on how to study English. The SPEC described the process of conducting interviews in English with Japanese professors from other departments at Sojo University, and then creating an activity using these video-recorded interviews as a tool for motivating students to study English on their own. This report will outline the main points discussed during the SPEC

Participatory politics, environmental journalism and newspaper campaigns

This is an Author's Accepted Manuscript of an article published in Journalism Studies, 13(2), 210 - 225, 2012, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/1461670X.2011.646398.This article explores the extent to which approaches to participatory politics might offer a more useful alternative to understanding the role of environmental journalism in a society where the old certainties have collapsed, only to be replaced by acute uncertainty. This uncertainty not only generates acute public anxiety about risks, it has also undermined confidence in the validity of long-standing premises about the ideal role of the media in society and journalistic professionalism. The consequence, this article argues, is that aspirations of objective reportage are outdated and ill-equipped to deal with many of the new risk stories environmental journalism covers. It is not a redrawing of boundaries that is needed but a wholesale relocation of our frameworks into approaches better suited to the socio-political conditions and uncertainties of late modernity. The exploration of participatory approaches is an attempt to suggest one way this might be done

A novel deliberative multicriteria evaluation approach to ecosystem service valuation

Although efforts to address ecosystem services in decision making have advanced considerably in recent years, there remain challenges related to valuation. In particular, conventional economic approaches have been criticized for their inability to capture the collective nature of ecosystem services, for their emphasis on monetary metrics, and the difficulty of assessing the value of ecosystem services to future generations. We present a deliberative multicriteria evaluation (DMCE) method that combines the advantages of multicriteria decision analysis with a deliberation process that allows citizens and scientists to exchange knowledge and evaluate ecosystem services in a social context. Compared with previous applications we add the following: (i) a choice task that can be expected to lead to a more reliable assessment of trade-offs among ecosystem services, and (ii) an explicit consideration of the future by both presenting specific socioeconomic scenarios and asking participating citizens to serve as “trustees” for future generations. We implemented our DMCE framework with 11 panels of residents of the upper Merrimack River watershed in New Hampshire with the goal of assessing the relative value of 10 different ecosystem services in the form of trade-off weights. We found that after group deliberation and expert scientific input, all groups except one were able to reach internal consensus on the relative value of these ecosystem services. Additionally, the pattern of trade-off weights across groups was reasonably similar; there was no statistically significant effect of the specific future scenarios that were presented to the groups. Results of a survey given to participants after the deliberative process revealed that most felt that their opinion during the deliberation was heard by the others and that they were influential on the outcome. Further, the vast majority were satisfied with the outcome of the deliberation. We conclude by discussing the strengths and limitations of our framework at an operational level

Student perceptions of an online extensive reading platform

Extensive reading (ER) has been shown to have a number of positive effects for learning a foreign language. Improvements in vocabulary size, reading fluency and comprehension, and grammatical accuracy are just some of the outcomes of extensive reading programs. Since 2011, extensive reading at Sojo University has been carried out through the use of graded readers, typically in the form of physical books made available to students either in class or through the Self-Access Learning Center (SALC). Recently, the popularity of reading texts in digital format has increased with the universal ownership of portable devices such as smartphones, tablets, and lightweight laptops. In April 2018, all second-year students at Sojo University were required to purchase a subscription to the Xreading website (www.xreading.com), which offers hundreds of graded readers in digital format. This study examines student perceptions of this platform. A total of 730 second-year students participated in the study, and the results appear to indicate that students feel extensive reading in general is a worthwhile activity to help them improve their English, but that the digital format provided by Xreading is not necessarily an improvement over physical books

New Routes and Opportunities for Modular Construction of Particulate Vaccines: Stick, Click, and Glue

Vaccines based on virus-like particles (VLPs) can induce potent B cell responses. Some non-chimeric VLP-based vaccines are highly successful licensed products (e.g., hepatitis B surface antigen VLPs as a hepatitis B virus vaccine). Chimeric VLPs are designed to take advantage of the VLP framework by decorating the VLP with a different antigen. Despite decades of effort, there have been few licensed chimeric VLP vaccines. Classic approaches to create chimeric VLPs are either genetic fusion or chemical conjugation, using cross-linkers from lysine on the VLP to cysteine on the antigen. We describe the principles that make these classic approaches challenging, in particular for complex, full-length antigens bearing multiple post-translational modifications. We then review recent advances in conjugation approaches for protein-based non-enveloped VLPs or nanoparticles, to overcome such challenges. This includes the use of strong non-covalent assembly methods (stick), unnatural amino acids for bio-orthogonal chemistry (click), and spontaneous isopeptide bond formation by SpyTag/SpyCatcher (glue). Existing applications of these methods are outlined and we critically consider the key practical issues, with particular insight on Tag/Catcher plug-and-display decoration. Finally, we highlight the potential for modular particle decoration to accelerate vaccine generation and prepare for pandemic threats in human and veterinary realms