1,601 research outputs found
On a shape adaptive image ray transform
A conventional approach to image analysis is to perform separately feature extraction at a low level (such as edge detection) and follow this with high level feature extraction to determine structure (e.g. by collecting edge points using the Hough transform. The original image Ray Transform (IRT) demonstrated capability to extract structures at a low level. Here we extend the IRT to add shape specificity that makes it select specific shapes rather than just edges, the new capability is achieved by addition of a single parameter that controls which shape is elected by the extended IRT. The extended approach can then perform low-and high-level feature extraction simultaneously. We show how the IRT process can be extended to focus on chosen shapes such as lines and circles. We confirm the new capability by application of conventional methods for exact shape location. We analyze performance with images from the Caltech-256 dataset and show that the new approach can indeed select chosen shapes. Further research could capitalize on the new extraction ability to extend descriptive capability
Adenovirus vector-specific T cells demonstrate a unique memory phenotype with high proliferative potential and coexpression of CCR5 and integrin αβ
Background: The Step Study was a randomized trial to reduce HIV infection through vaccination with an adenovirus type 5-based gag/pol/nef construct; analysis following early cessation of the trial revealed an excess of HIV seroconversion in Ad5 seropositive men. This led to the suggestion that the Ad based vector may boost the number of CD4 CCR5 T-cells, target cells for HIV infection.
Objectives: We sought to determine the immunophenotype and proliferative capacity of Ad5-specific T cells in the peripheral blood of adult donors to determine whether stimulation with replication defective Ad5 vectors could result in the significant expansion of a CD4 CCR5 T cell subset.
Methods: Ad5 specific T cells were identified in the peripheral blood of healthy donors by IFN- secretion assay and proliferative response was measured by CFSE labelling. Cells were analysed by flow cytometry to determine T cell differentiation marker, CCR5 and αβ expression on memory and proliferated cells.
Results: Ad5-specific CD4 T cells within healthy adult donors exhibit a unique minimally differentiated memory phenotype with co-expression of CD45RA, CD45RO and CCR7. Stimulation with Ad vector leads to rapid expansion in vitro and a switch to an effector memory phenotype. Both short-term reactivated and proliferating Ad5-specific CD4+ T-cells express the HIV co-receptor CCR5 and the HIV gp120-binding integrin αβ.
Conclusion: Ad5-specific T cells demonstrate a phenotype and proliferative potential that would support HIV infection; these results are pertinent to the findings of the Step Study and future use of Ad5 as a vaccine vector
Signatures of unconventional pairing in near-vortex electronic structure of LiFeAs
A major question in Fe-based superconductors remains the structure of the
pairing, in particular whether it is of unconventional nature. The electronic
structure near vortices can serve as a platform for phase-sensitive
measurements to answer this question. By solving Bogoliubov-de Gennes equations
for LiFeAs, we calculate the energy-dependent local electronic structure near a
vortex for different nodeless gap-structure possibilities. At low energies, the
local density of states (LDOS) around a vortex is determined by the
normal-state electronic structure. However, at energies closer to the gap
value, the LDOS can distinguish an anisotropic from a conventional isotropic
s-wave gap. We show within our self-consistent calculation that in addition,
the local gap profile differs between a conventional and an unconventional
pairing. We explain this through admixing of a secondary order parameter within
Ginzburg-Landau theory. In-field scanning tunneling spectroscopy near vortices
can therefore be used as a real-space probe of the gap structure
Mean-Field Analysis of Intra-Unit-Cell Order in the Emery Model of the CuO Plane
Motivated by recent experiments on high- cuprate superconductors
pointing towards intra-unit-cell order in the pseudogap phase, we investigate
three distinct intra-unit-cell-ordering possibilities: nematic,
nematic-spin-nematic, and current-loop order. The first two are Fermi-surface
instabilities involving a spontaneous charge and magnetization imbalance
between the two oxygen sites in the unit cell, respectively, while the third
describes circulating currents within the unit cell. We analyze the three-band
Emery model of a single CuO layer including various on-site and
nearest-neighbor interactions within a self-consistent mean-field approach. We
show how these on-site and further-neighbor repulsions suppress or enhance
particular IUC orders. In particular, we show that the attractive interactions
necessary for nematic and nematic-spin-nematic orders in one-band models have
their natural microscopic origin in the O-O on-site and nearest-neighbor
repulsions in the three-band model. Finally, we find that while the nematic and
nematic-spin-nematic orders cannot coexist in this framework, the loop-current
order can coexist with nematic order
Spin-Orbit Coupling in LaAlO/SrTiO interfaces: Magnetism and Orbital Ordering
The combination of Rashba spin-orbit coupling and electron correlations can
induce unusual phenomena in the metallic interface between SrTiO and
LaAlO. We consider effects of Rashba spin-orbit coupling at this interface
in the context of the recent observation of anisotropic magnetism. Firstly, we
show how Rashba spin-orbit coupling in a system near a band-edge can account
for the observed magnetic anisotropy. Secondly, we investigate the coupling
between in-plane magnetic-moment anisotropy and nematicity in the form of an
orbital imbalance between d / d orbitals. We estimate this
coupling to be substantial in the low electron density regime. Such an orbital
ordering can affect magneto transport
- …