Restricted Opportunities, Personal Choices, Ineffective Policies: What Explains Food Insecurity in Oregon?

This study examines the extent to which household demographics, local economic and social conditions, and federal food security programs explain the likelihood of household food insecurity in Oregon. Between 1999 and 2001, Oregon had the highest average rate of hunger in the nation and ranked in the top five states with respect to food insecurity. Statistical analyses using a multivariate logit model reveal that food insecurity is influenced by much more than demographics and individual choices. County-level factors such as residential location (urban versus rural) and housing costs significantly affect the likelihood that families will be food insecure.food insecurity, food stamps, hunger, rural residence, Food Security and Poverty,

Loss of signal transducer and activator of transcription 1 is associated with prostate cancer recurrence

STAT1 loss has previously been implicated in cell line studies to modify prostate cancer cell growth and survival, however the clinical significance of this has not previously been established. This study investigated if STAT1 loss was associated with patient outcome measures and the phenotypic consequence of STAT1 silencing. STAT1 expression was assessed in two patient cohorts with localised (n = 78) and advanced prostate cancer at initial diagnosis (n = 39) by immunohistochemistry (IHC). Impact of STAT1 silencing on prostate cancer cells lines was assessed using Cell Death detection ELISA, TLDA gene signature apoptosis arrays, WST-1 assay, xCELLigence system, clonogenic assay, and wound healing assay. In the localised patient cohort, low expression of STAT1 was associated with shorter time to disease recurrence (3.8 vs 7.3 years, P = 0.02) and disease specific survival (6.6 vs 9.3 years, P = 0.05). In the advanced patient cohort, low expression was associated with shorter time to disease recurrence (2.0 vs 3.9 years, P = 0.001). When STAT1 was silenced in PC3 cells (AR negative) and LNCaP cells (AR positive) silencing did not influence levels of apoptosis in either cell line and had little effect on cell viability in the LNCaP cells. In contrast, STAT1 silencing in the PC3 cells resulted in a pronounced increase in cell viability (WST-1 assay: mock silenced vs STAT1 silenced, P < 0.001), clonagenicity (clonogenic assay: mock silenced vs STAT1 silenced, P < 0.001), and migration (wound healing: mock silenced vs STAT1 silenced, P < 0.001). In conclusion, loss of STAT1 may promote prostate cancer recurrence in AR negative patients via increasing cell viability

Categorical information influences conscious perception: An interaction between object-substitution masking and repetition blindness

The visual system is constantly bombarded with dynamic input. In this context, the creation of enduring object representations presents a particular challenge. We used object-substitution masking (OSM) as a tool to probe these processes. In particular, we examined the effect of target-like stimulus repetitions on OSM. In visual crowding, the presentation of a physically identical stimulus to the target reduces crowding and improves target perception, whereas in spatial repetition blindness, the presentation of a stimulus that belongs to the same category (type) as the target impairs perception. Across two experiments, we found an interaction between spatial repetition blindness and OSM, such that repeating a same-type stimulus as the target increased masking magnitude relative to presentation of a different-type stimulus. These results are discussed in the context of the formation of object files. Moreover, the fact that the inducer only had to belong to the same "type" as the target in order to exacerbate masking, without necessarily being physically identical to the target, has important implications for our understanding of OSM per se. That is, our results show the target is processed to a categorical level in OSM despite effective masking and, strikingly, demonstrate that this category-level content directly influences whether or not the target is perceived, not just performance on another task (as in priming).This research was supported by an Australian Research Council (ARC) Discovery Early Career Research Award (DE140101734) awarded to S.C.G., and an ARC Discovery Project (DP110104553) grant awarded to M.E, and a UK Medical Research Council (MRC) Career Development Award to J.A.G. The authors thank Reuben Rideaux for assistance with the data collection

Ground state of a double-exchange system containing impurities: bounds of ferromagnetism

We study the boundary between ferromagnetic and non-ferromagnetic ground state of a double-exchange system with quenched disorder for arbitrary relation between Hund exchange coupling and electron band width. The boundary is found both from the solution of the Dynamical Mean Field Approximation equations and from the comparison of the energies of the saturated ferromagnetic and paramagnetic states. Both methods give very similar results. To explain the disappearance of ferromagnetism in part of the parameter space we derive from the double-exchange Hamiltonian with classical localized spins in the limit of large but finite Hund exchange coupling the $t-J$ model (with classical localized spins).Comment: 5 pages, 8 eps figures, latex; minor typos correcte