Cardiovascular morbidity and mortality after kidney transplantation

Kidney transplantation is the optimal treatment for patients with end stage renal disease (ESRD) who would otherwise require dialysis. Patients with ESRD are at dramatically increased cardiovascular (CV) risk compared to the general population. As well as improving quality of life, successful transplantation accords major benefits by reducing cardiovascular risk in these patients. Worldwide, cardiovascular disease remains the leading cause of death with a functioning graft and therefore is a leading cause of graft failure. This review focuses on the mechanisms underpinning excess cardiovascular morbidity and mortality and current evidence for improving cardiovascular risk in kidney transplant recipients. Conventional cardiovascular risk factors such as hypertension, diabetes mellitus, dyslipidaemia, and pre-existing ischaemic heart disease are all highly prevalent in this group. In addition, kidney transplant recipients exhibit a number of risk factors associated with pre-existing renal disease. Furthermore, complications specific to transplantation may ensue includingreduced graft function, side effects of immunosuppression and post transplantation diabetes mellitus. Strategies to improve cardiovascular outcomes post transplantation may include pharmacological intervention including lipid lowering or antihypertensive therapy, optimisation of graft function, lifestyle intervention and personalising immunosuppression to the individual patients risk profile

Spin-Statistics Violations in Superstring Theory

I describe how superstring theory may violate spin-statistics in an experimentally observable manner. Reviewing the basics of superstring interactions and how to utilize these to produce a statistical phase, I then apply these ideas to two specific examples. The first is the case of heterotic worldsheet linkings, whereby one small closed string momentarily enlarges sufficiently to pass over another, producing such a statistical phase. The second is the braneworld model with noncommutative geometry, whereby matter composed of open strings may couple to a background in which spacetime coordinates do not commute, modifying the field (anti)commutator algebra. I conclude with ways to sharpen and experimentally test these exciting avenues to possibly verify superstring theory.Comment: 18 pages, 3 figures; v2: references added and typos correcte

The Effect of Chemical Amendments Used for Phosphorus Abatement on Greenhouse Gas and Ammonia Emissions from Dairy Cattle Slurry: Synergies and Pollution Swapping

peer-reviewedLand application of cattle slurry can result in incidental and chronic phosphorus (P) loss to waterbodies, leading to eutrophication. Chemical amendment of slurry has been proposed as a management practice, allowing slurry nutrients to remain available to plants whilst mitigating P losses in runoff. The effectiveness of amendments is well understood but their impacts on other loss pathways (so-called ‘pollution swapping’ potential) and therefore the feasibility of using such amendments has not been examined to date. The aim of this laboratory scale study was to determine how the chemical amendment of slurry affects losses of NH3, CH4, N2O, and CO2. Alum, FeCl2, Polyaluminium chloride (PAC)- and biochar reduced NH3 emissions by 92, 54, 65 and 77% compared to the slurry control, while lime increased emissions by 114%. Cumulative N2O emissions of cattle slurry increased when amended with alum and FeCl2 by 202% and 154% compared to the slurry only treatment. Lime, PAC and biochar resulted in a reduction of 44, 29 and 63% in cumulative N2O loss compared to the slurry only treatment. Addition of amendments to slurry did not significantly affect soil CO2 release during the study while CH4 emissions followed a similar trend for all of the amended slurries applied, with an initial increase in losses followed by a rapid decrease for the duration of the study. All of the amendments examined reduced the initial peak in CH4 emissions compared to the slurry only treatment. There was no significant effect of slurry amendments on global warming potential (GWP) caused by slurry land application, with the exception of biochar. After considering pollution swapping in conjunction with amendment effectiveness, the amendments recommended for further field study are PAC, alum and lime. This study has also shown that biochar has potential to reduce GHG losses arising from slurry application.This research was funded by the Teagasc Walsh Fellowship Scheme and the AnimalChange Framework 7 Project (FP7-KBBE-2010-4)

Performance Factors and Management Practices Related to Earnings of East Central North Dakota Crop Farms

Agricultural Finance, Farm Management,

Recent Progress in Heavy Quark Physics

Some of the recent progress in heavy quark physics is reviewed. Special attention is paid to inclusive methods for determining Vub and factorization in nonleptonic B decays. Theoretical predictions for top-antitop production near threshold are also discussed.Comment: talk given at 2001 Lepton Photon Meeting, 10 pages, 5 figure

Orientation-dependent Casimir force arising from highly anisotropic crystals: application to Bi2Sr2CaCu2O8+delta

We calculate the Casimir interaction between parallel planar crystals of Au and the anisotropic cuprate superconductor Bi2Sr2CaCu2O8+delta (BSCCO), with BSCCO's optical axis either parallel or perpendicular to the crystal surface, using suitable generalizations of the Lifshitz theory. We find that the strong anisotropy of the BSCCO permittivity gives rise to a difference in the Casimir force between the two orientations of the optical axis, which depends on distance and is of order 10-20% at the experimentally accessible separations 10 to 5000 nm.Comment: 5 pages, 3 figures. Accepted for publication in Physical Review