Interview with Marjorie Elizabeth Howes on Colonial crossings: Figures in Irish literary history, by Marjorie Howes

In Colonial Crossings, Marjorie Howes is concerned with the responses of both major and minor literary figures to cultural conjectures in the emergence of modern Ireland. She illuminates the affective political power of secretions in the poetry of Lady Wilde, the shifting religious allegiances of William Carleton, Sheridan Le Fanu's deployment of femininity on the Anglo-Irish Gothic, and corporal punishment in the novels of the Irish-American writer Mary Anne Sadlier. Colonial Crossings also includes revelatory discussions of Joyce's Gretta Conroy and the question of female migration, and Yeats and the public sphere.Title supplied by cataloger

Clinical guidance on the identification and management of treatment-resistant schizophrenia

© Copyright 2019 Physicians Postgraduate Press, Inc. Treatment-resistant schizophrenia (TRS) occurs in approximately 30% of individuals diagnosed with schizophrenia. The identification and management of TRS in clinical practice are inconsistent and not evidence based. No established clinically relevant criteria for defining and treating TRS exist, although guidelines have been promulgated for clozapine use among TRS patients. This report summarizes the consensus from a roundtable that focused on defining and identifying TRS, pathways to treatment resistance, current treatments, unmet needs, and disease burden. Nine clinical experts in schizophrenia and TRS participated in a closed meeting on June 23, 2017, sponsored by Lundbeck, at which published literature in key areas of TRS research was reviewed. The findings from published studies were synthesized by experts in each area and presented to the group for review and discussion. It was agreed that inadequate response to 2 different antipsychotics, each taken with adequate dose and duration, is required to establish TRS. This recommendation is consistent with guidelines for clozapine use. For each trial, objective symptom measures should be used to assess treatment response, with medication adherence ensured. Once nonresponse is established (after ≥ 12 weeks for positive symptoms [2 trials of ≥ 6 weeks]), the treatment plan should be reevaluated and alternative pharmacologic or nonpharmacologic treatments considered. With increased awareness, those involved in the care of patients with schizophrenia will be able to identify TRS earlier in its course, thus supporting more informed treatment decisions by clinicians, patients, and caregivers to reduce the overall disease burden