Efficacy of Amla (Emblica officinanis) and Shibe yamani (potash alum) in the management of Candida vaginitis: a randomized standard controlled trial

Background: It has been estimated that 75% of all females experience at least one episode of Candida vaginitis with approximately 40-50% reporting a recurrence during their lifetime. The symptoms of vulvovaginal candidiasis are often painful and uncomfortable to the patient. The objective of this study was to assess the efficacy of Amla and Shibe yamani in the management of Candida vaginitis.Methods: This randomized, single blind, standard controlled study was done to compare the efficacy of Amla and Shibe yamani against fluconazole and 2% miconazole on diagnosed subjects of Candida vaginitis. Test group (n=30) received Amla with honey orally and Shibe yamani intra-vaginally at bed time for 3 wks. Whereas control group received standard regime of single dose fluconazole 150 mg orally and 5g of miconazole 2% cream intravaginally for 7 days. The primary outcome measure was relief in the vulvovaginal pruritus (reduction in 5D itch score). Secondary outcome measures included change in wet mount and improvement in vaginal discharge.Results: Vulvovaginal pruritus significantly decreased (P<0.001) after intervention in the two groups. Marked improvement was observed in vaginal discharge (P<0.001) in both the groups.70% of patients in test group and 80% in control group showed change in wet mount.Conclusions: Test drugs provide statistically significant improvement in vulvovaginal pruritus, vaginal discharge and in wet mount test without any apparent side effects. It can serve as an alternative treatment for Candida vaginitis

Efficacy of Asparagus recemosus (Satavar) in stimulating follicular growth and ovulation in anovulatory infertility: a randomized controlled trial

Background: Anovulation is the commonest cause of female infertility, responsible for 30% of cases and the most frequent cause of anovulation in women is polycystic ovarian syndrome. The aim of the study was to evaluate the anovulatory efficacy of Asparagus recemosus, commonly known as Satavar, in stimulating follicular growth and ovulation in an ovulatory infertility.Methods: A randomized standard controlled study was carried out at the National institute of Unani medicine Hospital, Bangalore. Patients (n=40) were randomly allocated to test (n=20) and control (n=20) groups. Infertile women in the age group of 18-40 years with menstrual irregularities, polycystic ovarian disease & spouse normal seminogram were included in the study. Patients with primary ovarian failure, thyroid dysfunction, hyperprolactinaemia, systemic illnesses, malignancy and those on hormonal therapy in last 3 months were excluded. In test group, 6 grams of A. recemosus powder twice daily from day 1-14 of cycle and in control group, clomiphene citrate 50 mg once daily from day 2-6 of cycle was administered orally for 2 consecutive cycles. Primary outcome measures (follicular growth & ovulation) and secondary outcome measure (conception) were assessed for improvement. Data were analyzed using Student ‘t’test, chi-square and Fisher exact test.Results: After 1st and 2nd cycles of treatment, follicular growth was 30% and 40% in test group and 60% & 50% in control group; ovulatory rate was 25% & 30% in test group and 40% & 25% in control group and conception rate was 0% in test group and 10 % and 5% in control group.Conclusions: The effect of test drug was comparable with that of control drug in stimulating follicular growth & ovulation, though the drug was not as effective as control drug to achieve conception. 

Efficacy of Amla (Emblica officinanis) and Shibe yamani (potash alum) in the management of Candida vaginitis: a randomized standard controlled trial

Background: It has been estimated that 75% of all females experience at least one episode of Candida vaginitis with approximately 40-50% reporting a recurrence during their lifetime. The symptoms of vulvovaginal candidiasis are often painful and uncomfortable to the patient. The objective of this study was to assess the efficacy of Amla and Shibe yamani in the management of Candida vaginitis.Methods: This randomized, single blind, standard controlled study was done to compare the efficacy of Amla and Shibe yamani against fluconazole and 2% miconazole on diagnosed subjects of Candida vaginitis. Test group (n=30) received Amla with honey orally and Shibe yamani intra-vaginally at bed time for 3 wks. Whereas control group received standard regime of single dose fluconazole 150 mg orally and 5g of miconazole 2% cream intravaginally for 7 days. The primary outcome measure was relief in the vulvovaginal pruritus (reduction in 5D itch score). Secondary outcome measures included change in wet mount and improvement in vaginal discharge.Results: Vulvovaginal pruritus significantly decreased (P&lt;0.001) after intervention in the two groups. Marked improvement was observed in vaginal discharge (P&lt;0.001) in both the groups.70% of patients in test group and 80% in control group showed change in wet mount.Conclusions: Test drugs provide statistically significant improvement in vulvovaginal pruritus, vaginal discharge and in wet mount test without any apparent side effects. It can serve as an alternative treatment for Candida vaginitis

Efficacy of Asparagus recemosus (Satavar) in stimulating follicular growth and ovulation in anovulatory infertility: a randomized controlled trial

Background: Anovulation is the commonest cause of female infertility, responsible for 30% of cases and the most frequent cause of anovulation in women is polycystic ovarian syndrome. The aim of the study was to evaluate the anovulatory efficacy of Asparagus recemosus, commonly known as Satavar, in stimulating follicular growth and ovulation in an ovulatory infertility.Methods: A randomized standard controlled study was carried out at the National institute of Unani medicine Hospital, Bangalore. Patients (n=40) were randomly allocated to test (n=20) and control (n=20) groups. Infertile women in the age group of 18-40 years with menstrual irregularities, polycystic ovarian disease &amp; spouse normal seminogram were included in the study. Patients with primary ovarian failure, thyroid dysfunction, hyperprolactinaemia, systemic illnesses, malignancy and those on hormonal therapy in last 3 months were excluded. In test group, 6 grams of A. recemosus powder twice daily from day 1-14 of cycle and in control group, clomiphene citrate 50 mg once daily from day 2-6 of cycle was administered orally for 2 consecutive cycles. Primary outcome measures (follicular growth &amp; ovulation) and secondary outcome measure (conception) were assessed for improvement. Data were analyzed using Student ‘t’test, chi-square and Fisher exact test.Results: After 1st and 2nd cycles of treatment, follicular growth was 30% and 40% in test group and 60% &amp; 50% in control group; ovulatory rate was 25% &amp; 30% in test group and 40% &amp; 25% in control group and conception rate was 0% in test group and 10 % and 5% in control group.Conclusions: The effect of test drug was comparable with that of control drug in stimulating follicular growth &amp; ovulation, though the drug was not as effective as control drug to achieve conception.