Relationship Between the Quorum Network (Sensing/Quenching) and Clinical Features of Pneumonia and Bacteraemia Caused by A. baumannii

Acinetobacter baumannii (Ab) is one of the most important pathogens associated with nosocomial infections, especially pneumonia. Interest in the Quorum network, i.e., Quorum Sensing (QS)/Quorum Quenching (QQ), in this pathogen has grown in recent years. The Quorum network plays an important role in regulating diverse virulence factors such as surface motility and bacterial competition through the type VI secretion system (T6SS), which is associated with bacterial invasiveness. In the present study, we investigated 30 clinical strains of A. baumannii isolated in the “II Spanish Study of A. baumannii GEIH-REIPI 2000-2010” (Genbank Umbrella Bioproject PRJNA422585), a multicentre study describing the relationship between the Quorum network in A. baumannii and the development of pneumonia and associated bacteraemia. Expression of the aidA gene (encoding the AidA protein, QQ enzyme) was lower (P < 0.001) in strains of A. baumannii isolated from patients with bacteraemic pneumonia than in strains isolated from patients with non-bacteraemic pneumonia. Moreover, aidA expression in the first type of strain was not regulated in the presence of environmental stress factors such as the 3-oxo-C12-HSL molecule (substrate of AidA protein, QQ activation) or H2O2 (inhibitor of AidA protein, QS activation). However, in the A. baumannii strains isolated from patients with non-bacteraemic pneumonia, aidA gene expression was regulated by stressors such as 3-oxo-C12-HSL and H2O2. In an in vivo Galleria mellonella model of A. baumannii infection, the A. baumannii ATCC 17978 strain was associated with higher mortality (100% at 24 h) than the mutant, abaI-deficient, strain (carrying a synthetase enzyme of Acyl homoserine lactone molecules) (70% at 24 h). These data suggest that the QS (abaR and abaI genes)/QQ (aidA gene) network affects the development of secondary bacteraemia in pneumonia patients and also the virulence of A. baumannii.National Plan for Scientific ResearchTechnological Development and Innovation PI16/01163ISCIII-Deputy General Directorate for Evaluation and Promotion of Research-European Regional Development Fund A way of Making EuropeInstituto de Salud Carlos IIIMiguel Servet Research Programme SERGAS and ISCIIIXunta de Galicia (GAIN, Axencia de Innovación

The Trp73 Mutant Mice: A Ciliopathy Model That Uncouples Ciliogenesis From Planar Cell Polarity

p73 transcription factor belongs to one of the most important gene families in vertebrate biology, the p53-family. Trp73 gene, like the other family members, generates multiple isoforms named TA and DNp73, with different and, sometimes, antagonist functions. Although p73 shares many biological functions with p53, it also plays distinct roles during development. Trp73 null mice (p73KO from now on) show multiple phenotypes as gastrointestinal and cranial hemorrhages, rhinitis and severe central nervous system defects. Several groups, including ours, have revisited the apparently unrelated phenotypes observed in total p73KO and revealed a novel p73 function in the organization of ciliated epithelia in brain and trachea, but also an essential role as regulator of ependymal planar cell polarity. Unlike p73KO or TAp73KO mice, tumor-prone Trp53−/− mice (p53KO) do not present ependymal ciliary or planar cell polarity defects, indicating that regulation of ciliogenesis and PCP is a p73-specific function. Thus, loss of ciliary biogenesis and epithelial organization might be a common underlying cause of the diverse p73KO-phenotypes, highlighting Trp73 role as an architect of the epithelial tissue. In this review we would like to discuss the data regarding p73 role as regulator of ependymal cell ciliogenesis and PCP, supporting the view of the Trp73-mutant mice as a model that uncouples ciliogenesis from PCP and a possible model of human congenital hydrocephalus

Introducing the "Pantano Project" to conserve the southernmost population of the marsh deer

El ciervo de los pantanos (Blastocerus dichotomus) es el cérvido nativo más grande de América del Sur y está clasificado como Vulnerable en la Lista Roja de la UICN. La población más austral de este cérvido se encuentra en el Bajo Delta del Río Paraná en Argentina. Debido a la caza furtiva, la pérdida de hábitat y la depredación por perros, se ha propuesto incrementar el estado de conservación de esta población a En Peligro. En 2015, implementamos "Proyecto Pantano", una iniciativa destinada a estudiar y conservar la población de ciervos de este humedal basada en la investigación, educación ambiental y concienciación pública. Estas acciones están destinadas a reconciliar la conservación del ciervo con la producción forestal en la región y mejorar el estado de conservación de uno de los humedales más importantes a nivel mundial.The marsh deer (Blastocerus dichotomus) is the largest native cervid of South America and is categorized as Vulnerable on the IUCN Red List. The southernmost population of this deer is found in the lower Delta of the Paraná River in Argentina. Due to poaching, habitat loss, and predation by dogs, it has been proposed to upgrade the conservation status of this population to Endangered. In 2015, we implemented the "Pantano Project", an initiative aimed at studying and conserving the marsh deer population of this wetland based on research, environmental education, and public awareness. These actions are intended to reconcile marsh deer conservation with the regional forestry management and improve the conservation status of one of the most important wetlands globally.Fil: Pereira, Javier Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; ArgentinaFil: Fergnani, Darío Martín. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; ArgentinaFil: Fernandez, Vanina Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; ArgentinaFil: Fracassi, Natalia Gabriela. Instituto Nacional de Tecnología Agropecuaria. Centro Regional Buenos Aires Norte. Estación Experimental Agropecuaria Delta del Paraná; ArgentinaFil: Gonzalez, Viridiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; ArgentinaFil: Lartigau, Bernardo Lartigau. Asociación Para la Conservación de la Naturaleza; ArgentinaFil: Marin, Violeta Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; ArgentinaFil: Tellarini, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; ArgentinaFil: Varela, Diego Varela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Universidad Nacional de Misiones. Instituto de Biología Subtropical; ArgentinaFil: Wolfenson, Laura Irene. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Museo Argentino de Ciencias Naturales “Bernardino Rivadavia”; Argentin

Dignidad, Poder, Resistencia // Dignity, Power, Resistance

First To Go Abroad is a partnership between the Loyola Marymount University First To Go Program, LMU Study Abroad, and the Council on International Educational Exchange (CIEE), which seeks to increase study abroad opportunities for first-generation college students. In May 2017, fifteen first-gen students and two first-gen faculty mentors traveled together to Santiago, Dominican Republic, where they spent ten days exploring the country and learning about the local cultures, customs, and histories of the people who call the DR home. Travel is a privilege not all students have the same access to; for some students, this trip was the first time out of the United States. Like the first-generation college experience, the experience of international travel is marked by daily encounters with new spaces, people, and cultural practices that can be at once overwhelming and inspiring. This was a topic of exploration throughout the trip and the subject of the pages contained in this volume. The narratives published here are the product of a cross-institutional writing workshop, where students from LMU and the Pontificia Universidad Católica Madre y Maestra worked together to draft essays documenting their encounters with change that have pushed boundaries, broken down borders, and generated personal growth. We hope our readers around the world will appreciate these works, which showcase the transformative power of creative and collaborative global encounters

Organizacion social del trabajo en la posmodernidad

trabajo conjunto derivado del cuerpo academico de la facultad de ciencias politicas. salud mental y vida cotidianadesde la posmodernidad se analiza y contribuye a la explicacion del fenomeno desde el trabajo precario, la violencia laboral, las universidades y la perspectiva de genero. La discusion invade el mundo del trabajo, el estress, mobing y , terrorismo laboral que se expande desde un cotidiano que puede estar en el hogar con el trabajo domestico hasta realidades del mundo empresarial y academico. Se observan sintomas y cuadro de organizaciones toxicas que contaminan el cotidiano y la salud social

Un lugar concreto desde el que vivir, mirar y pensar el mundo (educativo)

Editorial de presentación del Volumen 2 número 1 de Márgenes, Revista de Educación de la Universidad de Málaga. Quinto número de la revista, compuesto por un total de 17 textos, distribuidos en las diferentes secciones. Se trata de un número de carácter ecléctico en el que continuamos ofreciendo contenidos fieles a las premisas y los pilares educativos con los que partíamos

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO