Designing the ideal perioperative pain management plan starts with multimodal analgesia.

Multimodal analgesia is defined as the use of more than one pharmacological class of analgesic medication targeting different receptors along the pain pathway with the goal of improving analgesia while reducing individual class-related side effects. Evidence today supports the routine use of multimodal analgesia in the perioperative period to eliminate the over-reliance on opioids for pain control and to reduce opioid-related adverse events. A multimodal analgesic protocol should be surgery-specific, functioning more like a checklist than a recipe, with options to tailor to the individual patient. Elements of this protocol may include opioids, non-opioid systemic analgesics like acetaminophen, non-steroidal anti-inflammatory drugs, gabapentinoids, ketamine, and local anesthetics administered by infiltration, regional block, or the intravenous route. While implementation of multimodal analgesic protocols perioperatively is recommended as an intervention to decrease the prevalence of long-term opioid use following surgery, the concurrent crisis of drug shortages presents an additional challenge. Anesthesiologists and acute pain medicine specialists will need to advocate locally and nationally to ensure a steady supply of analgesic medications and in-class alternatives for their patients\u27 perioperative pain management

Contact values of the particle-particle and wall-particle correlation functions in a hard-sphere polydisperse fluid

The contact values $g(\sigma,\sigma')$ of the radial distribution functions of a fluid of (additive) hard spheres with a given size distribution $f(\sigma)$ are considered. A ``universality'' assumption is introduced, according to which, at a given packing fraction $\eta$, $g(\sigma,\sigma')=G(z(\sigma,\sigma'))$, where $G$ is a common function independent of the number of components (either finite or infinite) and $z(\sigma,\sigma')=[2 \sigma \sigma'/(\sigma+\sigma')]\mu_2/\mu_3$ is a dimensionless parameter, $\mu_n$ being the $n$-th moment of the diameter distribution. A cubic form proposal for the $z$-dependence of $G$ is made and known exact consistency conditions for the point particle and equal size limits, as well as between two different routes to compute the pressure of the system in the presence of a hard wall, are used to express $G(z)$ in terms of the radial distribution at contact of the one-component system. For polydisperse systems we compare the contact values of the wall-particle correlation function and the compressibility factor with those obtained from recent Monte Carlo simulations.Comment: 9 pages, 7 figure

Me matan si no trabajo y si trabajo… : la experiencia de la Confederación de los Trabajadores de la Economía Popular (CTEP)

El artículo 14 bis de la Constitución Argentina declara el derecho al trabajo en ciertas condiciones. Sin embargo, las leyes no siempre tienen un correlato con la realidad. Para entender esta cuestión es necesario comprender el desarrollo capitalista argentino. Desde la instauración del Estado-nación y del momento agro-exportador de principio de siglo XX, el llamado modelo de industrialización por sustitución de importaciones (ISI) quizás haya sido el momento más relevante de conformación de la estructura económica del país en el siglo pasado. Luego, a mediados de la década del 70, las políticas económicas y sociales de corte neo-liberal comenzaron un proceso de desestructuración del trabajo que se consolidó durante los noventa, generando desocupación y precarización masiva. El neo-desarrollismo logró avanzar en la creación de trabajo, pero no alcanzar condiciones básicas de bienestar. De esta forma, la clase obrera quedó fragmentada y debilitada, llegando a encontrar en los últimos años, cinco centrales sindicales y tres sectores de la economía: trans-nacional, nacional-local y popular. Esta última, la economía popular, agrupa aproximadamente a un 40% de los trabajadores. Dada la situación brevemente descripta, se puede afirmar que existieron diversas “condiciones de posibilidad" para que, en 2011, surgiera una organización como la Confederación de Trabajadores de la Economía Popular (CTEP). En esta ponencia se propone analizar el desarrollo de esta herramienta y las relaciones sociales que ha generado. En este contexto, además, resta mencionar que la CTEP se muestra como un actor relevante en la política nacional como se evidenció en la última discusión sobre la ley de “emergencia social" que impulsó la confederación junto a otras organizaciones populares y logró ser aprobada a fin del año pasado. En definitiva, la ponencia, buscará dar cuenta de complejidades y potencialidades, de resultados, perspectivas y debates a raíz de esta experiencia.Fil: Schejter, Mariano R.. Universidad Nacional de Villa Marí

Crisis Bureaucracy: Homeland Security and the Political Design of Legal Mandates

Policymakers fight over bureaucratic structure because it helps shape the legal interpretations and regulatory decisions of agencies through which modern governments operate. In this article, we update positive political theories of bureaucratic structure to encompass two new issues with important implications for lawyers and political scientists: the significance of legislative responses to a crisis, and the uncertainty surrounding major bureaucratic reorganizations. The resulting perspective affords a better understanding of how agencies interpret their legal mandates and deploy their administrative discretion. We apply the theory to the creation of the Department of Homeland Security. Two principal questions surrounding this creation are: (1) why the President changed from opposing the creation of a new department to supporting it and (2) why his plan for such a department was far beyond the scope of any other existing proposal. We argue that the President changed his mind in part because he did not want to be on the losing side of a major legislative battle. But more significantly, the President supported the massive new department in part to further domestic policy priorities unrelated to homeland security. By moving a large set of agencies within the department and instilling them with new homeland security responsibilities without additional budgets, the president forced these agencies to move resources out of their legacy mandates. Perversely, these goals appear to have been accomplished at the expense of homeland security. Finally, we briefly discuss more general implications of our perspective: first, previous reorganizations (such as FDR's creation of a Federal Security Agency and Carter's creation of an Energy Department) also seem to reflect presidential efforts to enhance their control of administrative functions, including some not directly related to the stated purpose of the reorganization; and, second, our analysis raises questions about some of the most often-asserted justifications for judicial deference to agency legal interpretations.

A Note on Unparticle Decays

The coupling of an unparticle operator O_U to Standard Model particles opens up the possibility of unparticle decays into standard model fields. We study this issue by analyzing the pole structure (and spectral function) of the unparticle propagator, corrected to account for one-loop polarization effects from virtual SM particles. We find that the propagator of a scalar unparticle (of scaling dimension 1 < d_U < 2) with a mass gap m_g develops an isolated pole, m_p^2-i m_p Gamma_p, with m_p^2 < m_g^2 below the unparticle continuum that extends above m_g (showing that the theory would be unstable without a mass gap). If that pole lies below the threshold for decay into two standard model particles the pole corresponds to a stable unparticle state (and its width Gamma_p is zero). For m_p^2 above threshold the width is non zero and related to the unparticle decay rate into Standard Model particles. This picture is valid for any value of d_U in the considered range.Comment: 11 pages, 4 figure

Cosmological Properties of a Gauged Axion

We analyze the most salient cosmological features of axions in extensions of the Standard Model with a gauged anomalous extra U(1) symmetry. The model is built by imposing the constraint of gauge invariance in the anomalous effective action, which is extended with Wess-Zumino counterterms. These generate axion-like interactions of the axions to the gauge fields and a gauged shift symmetry. The scalar sector is assumed to acquire a non-perturbative potential after inflation, at the electroweak phase transition, which induces a mixing of the Stuckelberg field of the model with the scalars of the electroweak sector, and at the QCD phase transition. We discuss the possible mechanisms of sequential misalignments which could affect the axions of these models, and generated, in this case, at both transitions. We compute the contribution of these particles to dark matter, quantifying their relic densities as a function of the Stuckelberg mass. We also show that models with a single anomalous U(1) in general do not account for the dark energy, due to the presence of mixed U(1)-SU(3) anomalies.Comment: 29 pages, 5 figures. Revised version, accepted by Phys. Rev.

Inhibition of larval growth of Ceratitis capitata Wied. by addition of antimetabolites to the larval diet.

A comparative study has been earried out in order to investigate the effects of cytarabine and ftorafur on the larval development and sex segregation of the Mediterranean fruit fly.Peer reviewe