DESENVOLVIMENTO E ACEITAÇÃO SENSORIAL DE COOKIES DE COCO ADICIONADOS DE CONCENTRADO PROTEICO DE PESCADO

O objetivo deste trabalho foi desenvolver formulações de biscoitos do tipo cookie, sabor coco, com e sem adição de concentrado proteico de pescado, comparando-as em relação à aceitabilidade sensorial, atitude de compra e idealidade da crocância. Foram desenvolvidas três formulações de cookies, uma padrão e as outras com adição de 51% e 83% de concentrado proteico de pescado. A  aceitação sensorial dos cookies foi verificada mediante escala hedônica, avaliando-se os atributos aparência, aroma, sabor e textura, bem como a aceitação global. Avaliou-se a intenção de compra dos consumidores em relação ao produto por meio de escala de atitude de compra e o grau de idealidade da crocância com o auxílio da escala do ideal. Os cookies padrão e adicionados de 51% de concentrado proteico de pescado obtiveram aceitação, não diferindo significativamente em nenhum atributo sensorial analisado. O cookie adicionado de 83% de concentrado proteico não obteve aceitação satisfatória, tornando inviável a sua comercialização devido ao fato de modificar negativamente as características sensoriais do produto.  

Acidose metabólica e o estado nutricional de pacientes em hemodiálise

Introduction: The prevalence of malnutrition in hemodialysis (HD) is high, being a marker of poor prognosis in chronic kidney disease. Metabolic acidosis is common on dialysis, and has been associated with mortality. Objectives: To evaluate metabolic acidosis and the nutritional status of HD patients. Methods: A cross-sectional study was carried out in a single HD center. Data were collected from medical records, and the presence of metabolic acidosis and the nutritional status of the patients were verified by anthropometric and biochemical indicators. Results: The total sample of 63 patients, 54% male and 46% female, with 58.7% between 45 and 64 years. The mean dialysis time was of 5.4 years. The mean value of the body mass index (BMI) was 24.9kg/m2, and the mean value of albumin was 3.9g/dL. The prevalence of metabolic acidosis was of 77.8%. There was a negative linear correlation between bicarbonate and creatinine, without correlation with anthropometric and albumin indicators. Patients malnourished according to the BMI corresponded to 55.5% of the total sample and gained more interdialytic weight. Out of the total sample, 14.2% of the patients were classified as malnourished by the arm circumference index, and albumin < 4.0 g/dL was observed in 49.2% of the patients. Serum creatinine was higher in male patients aged between 45 and 64 years old. No difference in time on hemodialysis was observed regarding age, interdialytic weight gain, laboratory, and anthropometric measures. Conclusion: The prevalence of metabolic acidosis was high, and there was no correlation with the nutritional status. Bicarbonate < 22 mEq/L was correlated with higher creatinine values, but was unrelated to the nutritional status. The nutritional assessment by BMI was in agreement with the Brazilian literature, and albumin indicated elevated malnutrition

Activation of Human CD11b+ B1 B-Cells by Trypanosoma cruzi-Derived Proteins Is Associated With Protective Immune Response in Human Chagas Disease

B-cells mediate humoral adaptive immune response via the production of antibodies and cytokines, and by inducing T-cell activation. These functions can be attributed to distinct B-cell subpopulations. Infection with Trypanosoma cruzi, the causative agent of Chagas disease, induces a polyclonal B-cell activation and lytic antibody production, critical for controlling parasitemia. Individuals within the chronic phase of Chagas disease may remain in an asymptomatic form (indeterminate), or develop severe cardiomyopathy (cardiac form) that can lead to death. Currently, there is no effective vaccine to prevent Chagas disease, and no treatment to halt the development of the cardiomyopathy once it is installed. The pathology associated with cardiac Chagas disease is a result of an inflammatory reaction. Thus, discovering characteristics of the host's immune response that favor the maintenance of favorable heart function may unveil important immunotherapeutic targets. Given the importance of B cells in antibody production and parasite control, we investigated T. cruzi-derived antigenic fractions responsible for B-cell activation and whether frequencies and functional characteristics of B-cell subpopulations are associated with different clinical outcomes of human Chagas disease. We stimulated cells from indeterminate (I) and cardiac (C) Chagas patients, as well as non-infected individuals (NI), with T. cruzi-derived protein- (PRO), glycolipid- (GCL) and lipid (LIP)-enriched fractions and determined functional characteristics of B-cell subpopulations. Our results showed that the frequency of B-cells was similar amongst groups. PRO, but not GCL nor LIP, led to an increased frequency of B1 B-cells in I, but not C nor NI. Although stimulation with PRO induced higher TNF expression by B1 B-cells from C and I, as compared to NI, it induced expression of IL-10 in cells from I, but not C. Stimulation with PRO induced an increased frequency of the CD11b+ B1 B-cell subpopulation, which was associated with better cardiac function. Chagas patients displayed increased IgM production, and activation of gamma-delta T-cells, which have been associated with B1 B-cell function. Our data showed that PRO activates CD11b+ B1 B-cells, and that this activation is associated with a beneficial clinical status. These findings may have implications in designing new strategies focusing on B-cell activation to prevent Chagas disease cardiomyopathy

A inclusão escolar para pacientes com deficiência intelectual ou atraso cognitivo: School inclusion for patients with intellectual disability or cognitive delay

A educação inclusiva é fundamental para que crianças e adolescentes vivenciem ideias e experiências de ensino aprendizagem significativa, desenvolvam a autonomia e conquistem direitos de cidadania. No entanto, existem obstáculos que precisam ser compreendidos e superados e estratégias que podem ser adotadas para promover a inclusão de crianças com deficiência intelectual ou atraso cognitivo. Diante disso, este estudo tem como objetivo compreender o processo de inclusão escolar de alunos com deficiência intelectual ou atraso cognitivo. Para isso, trata-se de uma revisão sistemática de literatura, desenvolvida a partir da seleção de estudos nas bases de dados Scielo, Pubmed e BVS/Medline a partir do uso de descritores DeCS/MeSH e aplicação de critérios de inclusão e exclusão. Após a análise e interpretação dos dados, concluiu-se que, no processo de inclusão de alunos com deficiência intelectual ou atraso cognitivo no ambiente escolar, a educação inclusiva interfere positivamente na qualidade de vida desses. Para isso, destacam-se uma série de estratégias relevantes, tais como: envolvimento de escola como um todo, dos professores e da família; compreender a deficiência; valorizar os interesses e habilidades dos alunos com deficiência; estimular a autodeterminação desses e a convivência entre pessoas deficientes e não deficientes; promover a socialização por meio de jogos; utilizar atividades adaptadas; e cuidar da formação inicial e continuada dos professores, contemplando ideias sobre educação inclusiva