The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer

According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further is associated with cell growth, proliferation, and survival, but also with activation of glucose metabolism. Mutations of the AKT signaling pathway components (especially PI3KCA and PTEN) have been observed in breast cancer patients, which are associated with resistance to hormonal treatment. Many clinical trials are testing the effect of AKT inhibition in order to block the growth and proliferation of breast cancer cells. The purpose of this review is to present the incidence of this neoplastic disease, to describe AKT signaling pathways activation, mutations that occur at its level, and inhibitors that can block this protein kinase

THE BEGINNING OF MODERNISM IN THE MUSIC OF SERBIAN COMPOSERS

Significantly penetrating the years between the two world wars, this situation testifies to the long process of uneven development of Serbian music. Despite the founding of the Belgrade Opera (1920), the gradual growth of performing qualities, the expansion of the repertoire, the premiere of the first Serbian musical and dramatic achievements of modern expression, the influence of popular music remains an almost exclusive privilege of traditional national forms of music. In order to establish internal continuity, they modernized and expanded the existing tradition with new genres, appreciating that sudden new leaps in language can be accepted primarily in those genres that have already gained some continuity in national music. REZUMAT. ÎNCEPUTURILE MODERNISMULUI ÎN MUZICA COMPOZITORILOR SÂRBI. Pătrunzând semnificativ în anii dintre cele două războaie mondiale, această situație atestă lungul proces de dezvoltare inegală a muzicii sârbești. În pofida înființării Operei din Belgrad (1920), a creșterii treptate a calităților interpretative, a extinderii repertoriului, a premierei primelor realizări muzicale și dramatice sârbești de expresie modernă, influența muzicii populare rămâne un privilegiu aproape exclusiv al formelor naționale tradiționale de muzică. Pentru a stabili o continuitate internă, acestea au modernizat și au extins tradiția existentă cu noi genuri, apreciind că salturile noi și bruște în limbaj pot fi acceptate în primul rând în acele genuri care au dobândit deja o anumită continuitate în muzica națională. Cuvinte cheie: modernism, sârbă, tradiție, naționalism, genuri

THE STYLISTIC FEATURES OF VASILIJE MOKRANJAC’S PIANO COMPOSITIONS

Vasilije Mokranjac can be seen as a paradigm for an entire generation of Serbian composers who started creating at an unfavourable historical moment. In time, he moved away from his initial stylistic ideas, and, by constant transformation of his practically neoclassical style, he created a heterogeneous work. He dealt most intensely with piano music and, as a result, he contributed the most, both quantitatively and qualitatively, to this area

Stylistic Correlations Between Serbian and European Music in the 20th Century

The Serbian musical culture was put late into connection with the European one. The fact that the first piano was introduced in Serbia in 1824 indicates that cultivating Serbian music was not possible under the Turkish domination. The spread of Serbian music in Europe made it possible to publish compositions by foreign authors and Serbian composers, which drew attention to the themes of Serbian music. The compositions were printed and published in Leipzig, Vienna, Prague, Paris, Budapest, London. The tours abroad performed by Serbian choirs and soloists popularized Serbian songs all over Europe. In the first half of the 20th century, almost 80 European composers wrote works with Serbian influences. Most of the foreign composers, especially those who lived and created among Serbians, embraced the mentality and cultural and musical needs of a people whose melodic essence they tapped into, using Serbian musical themes in their compositions

The Serine/Threonine Protein Kinase (Akt)/ Protein Kinase B (PkB) Signaling Pathway in Breast Cancer

According to statistical data published in 2019, breast cancer is among the leading causes of death in women worldwide. The serine/threonine kinase (AKT) or protein kinase B (PkB) signaling pathway is activated by phosphorylation processes, which further is associated with cell growth, proliferation, and survival, but also with activation of glucose metabolism. Mutations of the AKT signaling pathway components (especially PI3KCA and PTEN) have been observed in breast cancer patients, which are associated with resistance to hormonal treatment. Many clinical trials are testing the effect of AKT inhibition in order to block the growth and proliferation of breast cancer cells. The purpose of this review is to present the incidence of this neoplastic disease, to describe AKT signaling pathways activation, mutations that occur at its level, and inhibitors that can block this protein kinase

LYSYL OXIDASE (LOX) – A FUTURE NEW ALLY ON THE STAGE OF THE FIGHT AGAINST CANCER

The local extracellular matrix (EM) remodelling is considered one of the critical events in metastasis, both at primary and the secondary sites. One of the main actors on the EM remodelling is lysyl oxidase (LOX). In this connection, the aim of this paper is to bring to light a possible future systemic (and why not, salivary) biomarker of the metastatic process. LOX best-characterized role is in the EM remodelling by oxidative deamination of collagens and elastin peptidyl lysine residues, in order to facilitate covalent cross-linking. The LOX family members seem to play extremely important roles in these extracellular matrix interactions. Future research is needed to confirm whether simple LOX blocking or its downstream actions control could be regarded as target of preventive treatment in patients at a higher risk of metastasis. This is how the portrait of the future biomarker of LOX is becoming more and more outlined

URIC ACID – HISTORY, PRESENT AND FUTURE

2,6,8-trioxypurine known as uric acid represents a heterocyclic derivative of purine, with a molecular weight of 158 Da. In contrast to primates and humans, in the other animals uric acid is further oxidized by the uricase enzyme (urate oxidase) to allantoin, 100 times more water-soluble than uric acid and, consequently, more efficient excreted in the urine. Humans and higher pri¬mates lack a functional uricase gene. The uricase activity loss in higher primates and humans occurred about 15 million years ago, re¬sulting in a relatively higher plasma uric acid level than that in lower ani¬mals. This was an impressive and very important evolutionary event, providing essential survival advantages for humans. Uric acid represents a powerful antioxidant capable of scavenging singlet oxygen molecules, oxygen radicals, and peroxynitrite (ONOO−) molecules. However, in vivo and cellular research studies are interestingly illustrating that, depending on its chemical microenvironment, the uric acid molecule plays a duplicate role, being also a pro-oxidant. Uric acid represents the most important salivary antioxidant, in the circumstances of very low salivary thiols concentrations. Uric acid plays an important role in oral pathology and may be regarded as a very useful future salivary biomarker

Clinical and Laboratory Characteristics of Pediatric COVID-19 Population—A Bibliometric Analysis

The literature on the COVID-19 landscape has rapidly expanded in the pandemic period. The current study undertakes a bibliometric analysis of research in the topic of the clinical and laboratory characteristics of pediatric COVID-19 cases. Our aim is to perform a comprehensive bibliometric review of current research trends and patterns of this research domain. Publications retrieved from the Web of Science Core Collection and VOSviewer were used for analysis and network visualization. We analyzed geographical distribution and temporal trends, collaboration and citation patterns of authors, institutions, and countries, and core research themes from co-occurrence of keywords and terms. The analysis showed that contributions in the research field were from 302 publications, 1104 institutions, 62 countries, and 172 journals. Many publications were authored by American and Chinese authors, and many were published in the Pediatric Infectious Disease Journal, Pediatric Pulmonology, and Frontiers in Pediatrics. The top cited and co-cited journals were the New England Journal of Medicine, Nature, JAMA, Lancet Infectious Diseases, and BMJ. The network visualization maps of keywords and terms offered a global overview of the clinical and laboratory characteristics of pediatric COVID-19 patients. The bibliometric profile of the researched domain, based on analyzing a large collection of publications/data, could (i) enrich the researchers and non-researchers understanding of the field existing patterns and trends, and (ii) be useful in clinical practice (diagnostic and management) and public health policy

SUBOPTIMAL VITAMIN D STATUS IN INFANTS BETWEEN 1 AND 24 MONTHS OF AGE

Introduction. Vitamin D is well known for its role in calcium absorption and maintenance of healthy bones and its deficiency results in rickets. Serum 25-hydroxyVitamin D (25(OH) D) is the most abundant Vitamin D metabolite and its concentration reflects Vitamin D status in humans. The aim of this study was to analyse the level of 25(OH) D in children between 1 month and 24 months of age, admitted in Sibiu Children’s Hospital, with various pathologies, and to give scientific evidence for the prevention and treatment of rickets. Materials and methods. We made a retrospective study on 200 children, aged between 1 month and 24 months, hospitalized in different Pediatric Departments of Sibiu Children’s Hospital between 01.09.2015 and 01.11.2016, in whom we determined the level of serum 25(OH)D. The optimal level of 25(OH)D was considered to be ≥30 ng/ml; values of 25(OH) D between 20-29 ng/mL define insufficient Vitamin D and Vitamin D deficiency is characterized by levels < 20 ng/ml. Results. Overall, 111 children (55.5%), aged between 1 month and 24 months, had levels of 25 (OH) Vitamin D below 30 ng/ml, with a mean value of 28.68 ng/ml. Of these 111 patients, 87 (78%) had 25(OH)D values between 20-29 ng/ml, with a mean value of 22.61 ng/ml and only 24 children (22%) had values less 20 ng/ml, with a mean value of 17.2 ng/ml. Conclusions. Low serum 25(OH) D levels affect more than half of infants and children, aged 1 month to 24 months, suggesting that there are many children in our area who have suboptimal levels of Vitamin D and this should be a matter of concern for families with children, for medical professionals and public health authorities. Determination of 25(OH) Vitamin D is an important test for children between 1 month and 24 months of age, to be used as a starting point in efficiently preventing rickets at this age