Scores of FYN centrality indexes in Xk_to_P-tyr- and chorein_to_P-tyr- networks.

<p>(<b>A</b>) Eccentricity, closeness, radiality, betweenness, degree, stress and centroid centrality indexes of the src-related, protein tyrosine kinase FYN in the chorea-acanthocytosis (ChAc; chorein_to_P-tyr)-related sub-network. (<b>B</b>) Eccentricity, closeness, radiality, betweenness, degree, stress and centroid centrality indexes of the src-related, protein tyrosine kinase FYN in McLeod syndrome (MLS; Xk_to_P-tyr)-related sub-network. The score of every index was normalized to the maximal value for every index, considered as 100%. Red columns are relative values for FYN. Blue columns are average values. White columns are maximal values. Green columns are minimal values.</p

Centrality discretization in Xk_VPS13A-intersected network.

<p>(<b>A</b>) Plot of centroid vs. centroid centrality index values of all nodes in the Xk_ chorein-intersected network. (<b>B</b>) Plot of centroid vs. betweenness centrality index values of all nodes in the Xk_chorein-intersected network; the plot shows a concurrent discretization of centroid and betweenness, highlighting a cluster of 41 proteins having centroid and betweenness above the network average.</p

Examples of different locations of cerebral microbleeds in our sample of CADASIL patients.

<p>T2*-weighted magnetic resonance images showing cerebral microbleeds (white arrows) in infratentorial (A), deep subcortical (B, C) and lobar locations (D).</p

Stress, Betweenness and Centroid centrality indexes.

<p>Stress, Betweenness and Centroid centrality indexes.</p

Total number of cerebral microbleeds in 125 CADASIL patients.

<p>Proportions of patients with different numbers of CMB are reported in the bar graph and in the table.</p

Results of the baseline between group (SCA2 vs. controls) TBM analysis.

<p>Voxel-wise corrected p-value maps (threshold-free cluster enhancement, TFCE), testing the null hypothesis of zero differences in <b>|J|</b>_baseline between SCA2 patients and healthy controls. Highlighted clusters indicate significantly (p<0.05) more pronounced mean atrophy in SCA2 patients when compared to healthy controls (i.e. <b>|J|</b>_baseline in SCA2 patients significantly lower than <b>|J|</b>_baseline in healthy controls). All maps are overlayed on population-specific T1 template. These maps show significant symmetric atrophic changes in SCA2 patients (with respect to controls) in the brainstem, middle cerebellar peduncels, and cerebellar WM and adjacent cortical GM. No significant differences are observed in the supratentorial compartment.</p

Sub-network of proteins in the Xk_ chorein-intersected network.

<p>Sub-network of proteins in the Xk_chorein-intersected network having centroid and betweenness over the network average. The sub-network contains 41 proteins connected by 818 interactions. All proteins are kinases.</p

Demographic, genetic and clinical data in 10 SCA2 patients.

<p>F, female; IACRS, Inherited Ataxia Clinical Rating Scale; M, male; SD, standard deviation.</p

Correlation between the number of infratentorial, deep, and lobar cerebral microbleeds and drugs, clinical and other neuroimaging features in 125 CADASIL patients.

<p>Correlation between the number of infratentorial, deep, and lobar cerebral microbleeds and drugs, clinical and other neuroimaging features in 125 CADASIL patients.</p

DUSP13 shortest paths to dephosphorylated proteins in Xk_to_P-tyr-network.

<p>Graph of all shortest paths linking DUSP13 to INMT, PRPH, PRDX6 and ANXA4. A distance of 3 (ANXA4) or 4 (INMT, PRPH, PRDX6) degree separates DUSP13 from the proteins found dephosphorylated in red cell from patients with McLeod syndrome (MLS).</p