Analytical method (HPLC), validation used for identification and assay of the pharmaceutical active ingredient, Tylosin tartrate for veterinary use and its finite product Tilodem 50, hydrosoluble powder

In SC DELOS IMPEX ’96 SRL the quality of the active pharmaceutical ingredient (API) for the finite product Tilodem 50 - hydrosoluble powder was acomkplished in the respect of last European Pharmacopoeia.The method for analysis used in this purpose was the compendial method „Tylosin tartrate for veterinary use” in EurPh. in vigour edition and represent a variant developed and validation „in house”.The parameters which was included in the methodology validation for chromatographic method are the followings: Selectivity, Linearity, Linearity range, Detection and Quantification limits, Precision, Repeatability (intra day), Inter-Day Reproductibility, Accuracy, Robustness, Solutions’ stability and System suitability. According to the European Pharmacopoeia, the active pharmaceutical ingredient is consistent, in terms of quality, if it contains Tylosin A - minimum 80% and the amount of Tylosin A, B, C, D, at minimum 95%. Identification and determination of each component separately (Tylosin A, B, C, D) is possible by chromatographic separation-HPLC. Validation of analytical methods is presented below

INTERCULTURAL COMPETENCES AND INTERCULTURAL DIALOGUE. CASE STUDY ON BUCHAREST UNIVERSITY OF ECONOMICS

The paper debates the topics of intercultural competences and intercultural dialogue. The main research whose results are being disseminated through this paper are part of a national research project, "Equality of chances and intercultural dialogue", project granted by competition and which benefits from the expertise of a dynamic team of University Professors and lecturers as well as enthusiastic PhD students. The authors present the results of their academic and research activities involving students (both Romanian and foreign) studying Economics in foreign languages (at the Faculty of Business Administration taught in foreign languages, English section within the Bucharest University of Economics).intercultural dialogue, intercultural competence, intercultural sensitivity, knowledge-based society

How Apple Group Succeeded to Avoid Billions of Euros in Taxes by Shifting Profits into Subsidiaries from Ireland

The paper explores a subject that is getting more and more popular, namely how companies useloopholes to report domestic profits as being earned by subsidiaries in a tax haven, with the purposeto avoid paying taxes. I have chosen to present the case of the largest tech company in theworld: Apple Inc. Apple Inc., for two subsidiaries created in Ireland, benefited of a tax ruling agreement that wasin force between 1991 and 2014, attributing the profits to a head office with no tax residency andtherefore not taxable in Ireland or anywhere. The European Commission performed an in-depth investigation on the State Aid implementedby Ireland to Apple, and while it revealed the undue tax benefits that Ireland granted to the company,amounting 13 billion euros, that should be recovered, Apple claims that it does not owe asingle euro in any country around the world

A brief review of the literature on the malignant ureteral obstruction

Malignant ureteral obstruction (MUO) caused by a primarily urological tumor or secondary to a late-stage malignancy can be difficult for the urologist to manage. Due to a lack of clinical data on the management of MUO, every case is particular and should be aborted individually. Lack of specific treatment, either palliative or definitive, can severely damage renal function and lifetime expectancy in patients, causing even more damage that could otherwise be avoided. Prompt management directed at the recovery of renal function is the main goal in such cases. Even after urinary flow is restored, life threatening post-obstructive diuresis needs to be managed

Event by Event analysis of Maximum Pseudo-rapidity Gap Fluctuation in High energy Nucleus-nucleus Collisions

A study of Event by Event analysis of maximum Pseudo-rapidity Gap Fluctuation in heavy-ion collisions in terms of the scaled variance {\omega} has been carried out for relativistic AA collisions with multiplicity cut (N >10) using nuclear emulsion data at 4.5 AGeV/c. The values of scaled variance are found to be greater than zero indicating the presence of strong fluctuation of maximum rap gap values in the multiparticle production process. The event by event fluctuations are found to decrease with the increase of average multiplicity of the interactions. Experimental analysis has been compared with the results obtained from the analysis of events simulated by generating random numbers (MC-RAND events) and also by Ultra Relativistic Quantum Molecular Dynamics (UrQMD) model. UrQMD model simulated values of event by event fluctuations of maximum rapidity gap are less than the corresponding experimental values.Comment: 1 figure. arXiv admin note: substantial text overlap with arXiv:1802.0675