Tracheoesophageal fistula and anomalies of thoracic vessels: their occurrence in a case of congenital rubella

Made available in DSpace on 2011-11-01T16:37:06Z (GMT). No. of bitstreams: 2 license.txt: 1648 bytes, checksum: e095249ac7cacefbfe39684dfe45e706 (MD5) 1981 - Tracheoesophageal fistula and anomalies of thoracic vessels..pdf: 1617170 bytes, checksum: bb46121bc4d115a28cc7138a9b973252 (MD5) Previous issue date: 1981Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Virologic, gross, and microscopic studies of rubella embryopathy were performed. The presence of esophageal atresia with tracheal fistula allied with anomalies of the thoracic vessels were seen. We believe that both the mechanical action of the anomalous vessels on the developing organ, and the vascular degenerative aortic lesions, which are identical to those described in rubella syndrome, are probable causes of the esophageal malformation

Congenital papillomas and papillomatoses associated with the human papilloma virus (HPV)-report on 5 cases

Submitted by Maria Arruda ([email protected]) on 2019-10-21T16:18:47Z No. of bitstreams: 1 Congenital papillomas and papillomatoses associated with the human papilloma virus (HPV)-report on 5 cases. v113n4a06.pdf: 1518573 bytes, checksum: d4c1b4fb2167950a6a5c26e765c599c0 (MD5)Approved for entry into archive by Maria Arruda ([email protected]) on 2019-10-21T16:55:10Z (GMT) No. of bitstreams: 1 Congenital papillomas and papillomatoses associated with the human papilloma virus (HPV)-report on 5 cases. v113n4a06.pdf: 1518573 bytes, checksum: d4c1b4fb2167950a6a5c26e765c599c0 (MD5)Made available in DSpace on 2019-10-21T16:55:10Z (GMT). No. of bitstreams: 1 Congenital papillomas and papillomatoses associated with the human papilloma virus (HPV)-report on 5 cases. v113n4a06.pdf: 1518573 bytes, checksum: d4c1b4fb2167950a6a5c26e765c599c0 (MD5) Previous issue date: 1995Universidade Federal Fluminense. Departamento de Patologia. Niterói, RJ, Brasil.Universidade do Rio de Janeiro. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueiras. Patologia Clínica. Rio de Janeiro, RJ, Brasil.Introdução: Os autores apresentam um estudo de cinco casos de papilomas e papilomatoses vulvares congênitas em neo e nati-mortos. Material e Métodos: O material utilizado foi proveniente de cinco necrópsias. A avaliação histopatológica mostrou aspectos sugestivos de infecção pelo Pailomavirus humano (HPV). A microscopia eletrônica de três dos casos identificou partículas viróticas nucleares e citoplasmáticas variando de 40 a 60 nm, compatíveis com HPV. Resultados: O estudo imunohistoquímico destas lesões demonstrou imunopositividade citoplasmática e nuclear. Conclusão: Os autores concluíram que a presença de partículas viróticas somada a imunopositividade em células escamosas, são evidências do provável envolvimento etiológico do HPV nestas lesões.The authors present a study of five cases of vulvar congenital papillomas and papillomatoses in stillborns and neonates dead upon birth. The studied material was collected from five necropsies. The histopathological evaluation showed hyperkeratosis, acanthosis, papillomatosis, perinuclear haloes, and nuclear abnormalities. In three of the cases, the electron microscopy identified nuclear and cytoplasmatic viral particles ranging from 40 to 60 nm in size, compatible with HPV. The immunohistochemical study of those lesions showed nuclear and cytoplasmatic positivity. The authors concluded that the presence of viral particles suggestive of HPV added to the immunopositivity indicated the possibility of viral infection

Congenital papillomas and papillomatoses associated with the Human Papilloma Virus (HPV): report on 5 cases

The authors present a study of five cases of vulvar congenital papillomas and papillomatoses in stillborns and neonates dead upon birth. The studied material was collected from five necropsies. The histopathological evaluation showed hyperkeratosis, acanthosis, papillomatosis, perinuclear haloes, and nuclear abnormalities. In three of the cases, the electron microscopy identified nuclear and cytoplasmatic viral particles ranging from 40 to 60 nm in size, compatible with HPV. The immunohistochemical study of those lesions showed nuclear and cytoplasmatic positivity. The authors concluded that the presence of viral particles suggestive of HPV added to the immunopositivity indicated the possibility of viral infection

Congenital echo virus infection morphological and virological study of fetal and placental tissue

Made available in DSpace on 2011-11-01T16:37:05Z (GMT). No. of bitstreams: 2 license.txt: 1648 bytes, checksum: e095249ac7cacefbfe39684dfe45e706 (MD5) 1990 - Congenital echo vírus infection morphological and virological study of fetal and placental tissue..pdf: 2798677 bytes, checksum: b2352a3b035253e50a4a4ce4407830fb (MD5) Previous issue date: 1990Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Virologia e Setor de Microscopia Eletrônica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Virologia e Setor de Microscopia Eletrônica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.A prospective study of 78 pregnant women was undertaken to detect maternal enterovirus infection. Maternal faecal especimens and blood samples, placental and fetal tissue were taken for viral study, electron microscopy, histochemistry, and morphological examination. We present the post-mortem findings in three fetuses whose maternal infection was detected before delivery by isolation of ECHO virus type 33 and type 27 from faecal specimens and/or placental and fetal tissues. The morphological aspects were similar in all cases and included an acute infection of the placenta and hypoxic/hypotensive injury to fetal organs. In one case, viral particles were detected by electron microscopy of the fetal liver. This series of cases of intrauterine ECHO virus infection confirms the potential gravity of such infection during pregnancy and the need to prevent enteroviral disease

Aspectos ultra-estruturais do citomegalovírus humano: em órgãos fetais - baço, pulmão e cérebro

Made available in DSpace on 2011-11-01T16:37:05Z (GMT). No. of bitstreams: 2 license.txt: 1648 bytes, checksum: e095249ac7cacefbfe39684dfe45e706 (MD5) 1984 - Aspectos ultra-estruturais do citomegalovírus humano.pdf: 1262808 bytes, checksum: 7a4e78ac8ee8b9476a1add5d2c240a7d (MD5) Previous issue date: 1984Universidade Federal do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Instituto de Matemática. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Conselho de Ensino de Pós-graduação. Rio de Janeiro, RJ, Brasil.Universidade Federal do Estado do Rio de Janeiro. Conselho de Ensino de Pós-graduação. Rio de Janeiro, RJ, Brasil.Um estudo ultra-estrutural de casos de doenças congênitas foi realizado em três órgãos (baço, pulmão, cérebro). Partículas herpéticas foram observadas tanto no núcleo como no citoplasma dos órgãos estudados. os aspectos ultra-estruturais foram destacados por seu caráter de importância no diagnóstico por seu caráter de importância no diagnóstico da infecção viral

Enterovirus associated placental morphology: a light, virological, electron microscopic and immunohistologic study

Made available in DSpace on 2011-11-01T16:37:01Z (GMT). No. of bitstreams: 2 license.txt: 1648 bytes, checksum: e095249ac7cacefbfe39684dfe45e706 (MD5) 1991 - enterovirus associated placental morphology2.pdf: 2583786 bytes, checksum: 6aa396c34eda9033c3640a8820f11db6 (MD5) Previous issue date: 1991Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Anatomia Patológica. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Virologia e Setor de Microscopia Eletrônica. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Virologia e Setor de Microscopia Eletrônica. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Virologia e Setor de Microscopia Eletrônica. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Virologia e Setor de Microscopia Eletrônica. Rio de Janeiro, RJ, BrasilThe purpose of this study was to identify the possible effect of enteroviruses on placental tissue. Seventy-eight pregnant women were studied throughout their pregnancy: enteroviral infection was detected by faecal viral isolation and seric neutralization of previously identified virus in cell culture. In 19 cases of confirmed maternal infection, placentae were examined grossly, by optical microscopy, immunohistochemical and electron microscopic methods. Ten term placentae from women included in the study, with no clinical, serological or virological evidence of enteroviral infection, were used as control, and examined by gross and optical microscopy. In 17 specimens (echovirus-coxsackievirus) an haematogenous placentitis was suspected on the basis of gross observation. Microscopic lesions were similar to those found in other viral infections, with specific features. The nature of the inflammatory reaction pointed to the presence of an acute type of haematogenous placentitis, not present in placentae of the control group. The authors (AA) comment on the results and present the hypotheses about the available data: (1) maternal enteroviremia and faecal virus shedding without placental invasion, placentary damage being an unspecific consequence of infection; (2) direct virus-induced injury is not the only possible cause for the lesions: (3) placental enteroviral infection occurred with placental pathology but the virus did not cross the organ as the newborn had no signs of infection

FETO-PLACENTARY PATHOLOGY IN HUMAN PARVOVIRUS B19 INFECTION

In view of the scarce references concerning the histological data in congenital parvovirus human B19 infection, we intend to provide a description of the pathological features observed in six autopsies.The virus was detected by DNA hybridization (ISH-DBH),PCR and electronmicroscopy (EM) in paraffin-embedded feto-placentary tissues.These cases constitute a subset from 86 Non Immunologic Hydrops Fetalis (NIHF) cases, in which a systemic complex of inflammatory/degenerative lesions of unknown etiology was visualized by optical microscopy. In one case a syphilitic process was detected, typefying a double infection. All fetuses showed a similar pathology - hydrops, hepato-splenomegaly, lung hypoplasia and erythroblastemia, the specific histological feature being the presence of intranuclear inclusions in the erythroid progenitors, in the erythropoietic visceral tissue and in blood marrow. Complex cardiopathy allied to abnormal lung lobulation and polisplenia were observed once; in 2 cases endocardial fibroelastosis was diagnosed. The pulmonary lesions were represented by dysmaturity allied to interstitial mononuclear infiltration. The hepatic consisted of cholestasis, portal fibrosis, canalicular proliferation, hemossiderosis, focal necroses and giant cell transformation. The central nervous system lesions were predominantly anoxic although the autolysis impaired a correct diagnosis

Maternal Chlamydia trachomatis infection and fetal abortion

Made available in DSpace on 2011-11-01T16:37:07Z (GMT). No. of bitstreams: 2 license.txt: 1648 bytes, checksum: e095249ac7cacefbfe39684dfe45e706 (MD5) 1994 - Infecção materna por Chlamydia trachomatis associada a aborto fetal (1).pdf: 839176 bytes, checksum: 3e230edf928f57aa95e7017d43905f1c (MD5) Previous issue date: 1994Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Anatomia Patológica e Citopatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Anatomia Patológica e Citopatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Anatomia Patológica e Citopatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Anatomia Patológica e Citopatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Anatomia Patológica e Citopatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Anatomia Patológica e Citopatologia. Rio de Janeiro, RJ, Brasil.Os autores apresentam os dados obtidos pelo estudo morfológico i imunohistoquímico de aborto fetal em caso de infecção clamidiana materna. Verificou-se na placenta a presença de lesões decorrentes de processo infeccioso agudo do tipo hematogênico, caracterizado por vilosite, intervilosite, vascularite coriônica e coriamnionite. Estruturas com morfologia de corpos clamidianos foram observadas em vários tipos de células placentárias (epitélio amniótico, trofoblasto viloso, citotrofoblasto extraviloso e célula decidual). A patologia fetal consistiu de focos de necrose visceral sugestivos de disseminação da infecção pela placenta. Através do uso de soro monoclonal contra a Chlamydia trachomatis (Ct), identificou-se positividade através de imunofluorescência em estruturas intracelulares exibindo morfologia compatível com a de inclusões clamidianas. A presença de Ct foi observada no exame rotineiro do esfregaço cervical materno e posteriormente isolada em cultura de células.The authors report and comment on a morphological and immunohistochemical study of feto-placentary tissues from an abortion associated with Chlamydia trachomatis (Ct) infection of maternal cervical smears. Morphology of the placenta revealed gross and histological features compatible with an acute type of hematogenic infection. The latter was manifested as villitis, intervillitis, chorionic vasculitis and mild chorionamnionitis. The presence of structures compatible with chlamydial cells (amniotic epithelium, villous trophoblast, extravillous cytotrophoblast and decidual cells) was observed. The fetal pathology consisted of focal visceral necrosis suggestive of dissemination of infection from the placenta. Immunofluorescence assays were perfomed using a monoclonalantibody against Ct. These assays revealed positive applegreen fluorescence localized to intra-cellular structures with morphology of chlamydial bodies, at the sites of the lesions above described. Ct was detected in routine maternal cervical smears and was also isolated from this material in cell culture

Enterovirus isolation from foetal and placental tissues

Made available in DSpace on 2011-11-01T16:37:06Z (GMT). No. of bitstreams: 2 license.txt: 1648 bytes, checksum: e095249ac7cacefbfe39684dfe45e706 (MD5) 1990 - Enterovirus isolation from foetal and placental tissue..pdf: 4269718 bytes, checksum: c5e5d3ea70d6af9ffb4cea28eedd179c (MD5) Previous issue date: 1990Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia. Departamento de Virologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Four spontaneous abortions and two stillbirth occurred during a prospective survey following the teratogenicity of echoviruses in 80 pregnant women selected at random from the Antenatal Care Service. Echovirus types 19, 27, and 33. Coxsackie B2 and B6 were isolated from placental and foetal tissues (brain, liver, kidney, heart, and spleen). The mothers also excreted the virus by faeces at least twenty days before abortion and responded serologically, indicating active virus infection. Almost all aborted children were anomalous with signs of viral infection