110 research outputs found

    RAMATH: Innovation in the learning environment of military-technological higher education

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    The present project is the analysis  on  the  acceptability  of  augmented  reality in the learning of military students of the Superior Technology in Military Sciences at Escuela de Formación de Soldados del Ejército ”Vencedores del Cenepa” (ESFORSE). According to the curricular structure in dual formative modality, the adaptation index would be to submit educational innovations promoting teaching-learning with the RA, creating quality educational and pedagogical resources for teachers, military instructors and students, interacting with technology; improving knowledge in the subject of Mathematical Foundations. The evidential result is the educational indicators designed for RA applications with practical functions that include the study methodology in the Mathematical Foundations subject. The adaptability in this topic was validated through an explanation of selected applications considering characteristics, techniques, configurations, as well as the discussed topics in the subject, included in the work under study. Resumen. El presente proyecto es el análisis sobre la aceptabilidad de la realidad aumentada en el aprendizaje de los estudiantes militares de la carrera de Tecnología Superior en Ciencias Militares, en la Escuela de Formación de Soldados del Ejército “Vencedores del Cenepa” (ESFORSE), según la estructura curricular en modalidad formativa dual, el índice de adaptación sería el presentar innovaciones educativas potenciando la enseñanza, aprendizaje con la RA, creando recursos educativos de calidad y pedagógicos para docentes, instructores militares y estudiantes, interactuando con la tecnología, mejorando los conocimientos en la asignatura de Fundamentos Matemáticos. El resultado evidenciable son los marcadores educativos diseñados para aplicaciones de RA con funciones prácticas incluyendo la metodología de estudio en la materia de Fundamentos Matemáticos. La adaptabilidad en esta materia se validó mediante una explicación de las aplicaciones seleccionadas considerando características, técnicas, configuraciones; así como los temas tratados en la asignatura, incluidos dentro del trabajo de estudio

    Cooperativismo y desarrollo sostenible en el Ecuador

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    Las cooperativas por su propio origen y naturaleza, son negocios socialmente responsables por tanto, deberían jugar un papel fundamental en la implementación de la Agenda 2030, mediante la práctica de sus principios y valores y  la reinversión de sus excedentes en los territorios donde ejerce su acción, a través del apoyo financiero en la producción de bienes y servicios, en respuesta a las necesidades de las comunidades locales y así ayudar a la erradicación de los problemas estructurales de la sociedad y el favorecimiento de un desarrollo sostenible e igualitario. La presente investigación, describe el trabajo realizado por las entidades Cooperativas de Ahorro y Crédito del país en relación con los Objetivos del Desarrollo Sostenible, ODS, establecidos; lo cual ha determinado que el aspecto económico- financiero es una prioridad principal para estas entidades, debido al control y la supervisión a la cual están sujetas. Por otro lado, los aspectos sociales y ambientales siguen pendientes, hecho que limita al sector asumir integralmente los compromisos acordados en la V Cumbre Cooperativa de la Américas sobre el tema

    Subsidence damage assessment of a Gothic church using differential interferometry and field data

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    The Santas Justa and Rufina Gothic church (fourteenth century) has suffered several physical, mechanical, chemical, and biochemical types of pathologies along its history: rock alveolization, efflorescence, biological activity, and capillary ascent of groundwater. However, during the last two decades, a new phenomenon has seriously affected the church: ground subsidence caused by aquifer overexploitation. Subsidence is a process that affects the whole Vega Baja of the Segura River basin and consists of gradual sinking in the ground surface caused by soil consolidation due to a pore pressure decrease. This phenomenon has been studied by differential synthetic aperture radar interferometry techniques, which illustrate settlements up to 100 mm for the 1993–2009 period for the whole Orihuela city. Although no differential synthetic aperture radar interferometry information is available for the church due to the loss of interferometric coherence, the spatial analysis of nearby deformation combined with fieldwork has advanced the current understanding on the mechanisms that affect the Santas Justa and Rufina church. These results show the potential interest and the limitations of using this remote sensing technique as a complementary tool for the forensic analysis of building structures.Roberto Tomás is supported by a Generalitat Valenciana fellowship BEST-2011/225. The European Space Agency (ESA) Terrafirma project has funded all the SAR data processing with the SPN technique. Additionally, this study has been partially financed by the projects: TEC-2008-06764, TEC2011-28201-C02-02 ACOMP/2010/082, VIGROB-157, and 15224/PI/10

    Myositis ossificans of the masseter muscle: a rare location. Report of a case and review of literature

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    Background: Myositis Ossificans is a rare heterotopic bone formation within a muscle being the masticatory muscles exceptionally involved. In most cases there is a previous trauma, bearing in mind that there may be many other etiologies. CT scan and panoramic radiographs along with histological findings are essential diagnostic aids. Case Desciption: we report a rare case of MO of masseter muscle in 49 years-old woman after repetitive wisdom tooth infection with the discussion of clinical, radiological and histological features. Clinical Implications: MO is a rare disease of masticatory muscles being the masseter the most frequently affected. Wide surgical excision with free margins is the treatment of choice although close postoperative monitoring it’s essential to avoid relapses

    Artificial intelligence for automatically detecting animals in camera trap images: a combination of MegaDetector and YOLOv5

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    Camera traps have gained high popularity for collecting animal images in a cost-effective and non-invasive manner, but manually examining these large volumes of images to extract valuable data is a laborious and costly process. Deep learning, specifically object detection techniques, constitutes a powerful tool for automating this task. Here, we describe the development and result of a deep-learning workflow based on MegaDetector and YOLOv5 for automatically detecting animals in camera trap images. For the development, we first used MegaDetector, which automatically generated bounding boxes for 93.2% of the images in the training set, differentiating animals, humans, vehicles, and empty photos. This annotation phase allowed to discard useless images. Then, we used the images containing animals within the training dataset to train four YOLOv5 models, each one built for a group of species of similar aspects as defined by a human expert. Using four expert models instead of one reduces the complexity and variance between species, allowing for more precise learning within each of the groups. The final result is a workflow where the end-user enters the camera trap images into a global model. Then, this global model redirects the images towards the appropriate expert model. Finally, the final animal classification into a particular species is based on the confidence rates provided by a weighted voting system implemented among the expert models. We validated this workflow using a dataset of 120.000 images collected by 100 camera traps over five years in Andalusian National Parks (Spain) with a representation of 24 mammal species. Our workflow approach improved the global classification F1-score from 0.92 to 0.96. It increased the precision for distinguishing similar species, for example from 0.41 to 0.96 for C. capreolus; and from 0.24 to 0.73 for D. dama, often confounded with other ungulate species, which demonstrates its potential for animal detection in images.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

    Gender and women's work in Peru

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    This study identifies the peruvian women's labor conditions and its social and historical determinants due to social class, race and gender differences that influence women subordination in social structure. Bibliographic review shows that the peruvian working woman situation experienced great and deep changes in time, as a result of ideological and cultural patriarchal patterns that culminated in the current capitalist society.En este estudio se identifican las condiciones de trabajo de la mujer en el Perú con sus determinantes histórico-sociales, derivados de la diferenciación por clase social, raza y género que condicionan la subordinación de las mujeres en la estructura social. A través de revisión bibliográfica se verifica que la situación de la mujer peruana trabajadora, ha tenido grandes y profundas transformaciones a través del tiempo, condicionadas por patrones ideológico-culturales patriarcales que culminaron en la sociedad capitalista periférica de los dias actuales

    Holistic assessment of the microbiome dynamics in the substrates used for commercial champignon (Agaricus bisporus) cultivation

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    Microorganisms strongly influence and are required to generate the selective substrate that provides nutrients and support for fungal growth, and ultimately to induce mushroom fructification under controlled environmental conditions. In this work, the fungal and bacterial microbiota living in the different substrates employed in a commercial crop (compost phase I, II and III, flush 1 and 2, and casing material on day 1, 6 and 8 after compost casing and during flush 1 and 2) have been characterized along the different stages of cultivation by metataxonomic analysis (16S rRNA and ITS2), analysis of phospholipid fatty acid content (PLFAs) and RT-qPCR. Additionally, laccase activity and the content of lignin and complex carbohydrates in compost and casing have been quantified. The bacterial diversity in compost and casing increased throughout the crop cycle boosted by the connection of both substrates. As reflected by the PLFAs, the total living bacterial biomass appears to be negatively correlated with the mycelium of the crop. Agaricus bisporus was the dominant fungal species in colonized substrates, displacing the pre-eminent Ascomycota, accompanied by a sustained increase in laccase activity, which is considered to be a major product of protein synthesis during the mycelial growth of champignon. From phase II onwards, the metabolic machinery of the fungal crop degrades lignin and carbohydrates in compost, while these components are hardly degraded in casing, which reflects the minor role of the casing for nourishing the crop. The techniques employed in this study provide a holistic and detailed characterization of the changing microbial composition in commercial champignon substrates. The knowledge generated will contribute to improve compost formulations (selection of base materials) and accelerate compost production, for instance, through biotechnological interventions in the form of tailored biostimulants and to design environmentally sustainable bio-based casing materialsThe project was funded by the H2020 programme under the Marie Sklodowska-Curie grant agreement no. 742966 and also funded by the ADER project grant no. 2016-IDD-00013. [Correction added on 07 August 2020 after first online publication: Figures 3 and 5 have been corrected in this version

    18F-FDG metabolism in a rat model of chronic infarction: a 17-sector semiquantitative analysis

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    Strategies to establish the functional benefit of cell therapy in cardiac regeneration and the potential mechanism are needed. Aims: Development of a semi-quantitative method for non invasive assessment of cardiac viability and function in a rat model of myocardial infarction (MI) based on the use of microPET. Animals, methods: Ten rats were subjected to myocardial imaging 2, 7, 14, 30, 60 and 90 days after left coronary artery ligation. Intravenous 18F-fluoro-2-deoxy-2-D-glucose (18F-FDG) was administered and regional 18F activity concentrations per unit area were measured in 17 regions of interest (ROIs) drawn on cardiac polar maps. By comparing the differences in 18F uptake between baseline and each of the follow up time points, parametric polar maps of statistical significance (PPMSS) were calculated. Left ventricular ejection fraction (LVEF) was blindly assessed echocardiographically. All animals were sacrificed for histopathological analysis after 90 days. Results: The diagnostic quality of 18F-FDG microPET images was excellent. PPMSS demonstrated a statistically significant decrease in 18F concentrations as early as 48 hours after MI in 4 of the 17 ROIs (segments 7, 13, 16 and 17; p <0.05) that persisted throughout the study. Semi-quantitative analysis of 18F-FDG uptake correlated with echocardiographic decrease in LVEF (p <0.001). Conclusion: The use of PPMSS based on 18F-FDG-microPET provides valuable semi-quantitative information of heart glucose metabolism allowing for non-invasive follow up thus representing a useful strategy for assessment of novel therapies in cardiac regeneration

    Cronología y temporalidad de los recintos de fosos prehistóricos: el caso de Marroquíes Bajos (Jaén)

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    The time spans of the so-called ditched enclosures are key to a better understanding of a type of site characterised by complex palimpsests. Several conclusions can be drawn from the 16 radiocarbon dates obtained from Ditch 4 at Marroquíes Bajos. According to Bayesian modelling, the filling process began in 2510-2310 cal BC at 2 σ and ended in 2115-1795 cal BC at 2 σ, making them the most recent ditched enclosure with depositional activity in Iberia. Comparison with the dating from other sections of Ditch 4 challenges the traditional assumption that radiocarbon samples obtained from deposits at the bottom of the ditch provide the best dates for its construction. The process by which different sections of the same Ditch 4 were filled at different times suggests that its general outline is more the result of an aggregation of segments than of a single build-up.La temporalidad de los denominados recintos de fosos es un aspecto clave para la correcta compresión de un tipo de yacimiento caracterizado por auténticos palimpsestos de complicada secuenciación. La serie de 16 dataciones radiocarbónicas obtenidas en el Foso 4 de Marroquíes Bajos ha permitido establecer varias conclusiones. Según la modelización bayesiana el inicio del proceso de colmatación se sitúa entre el 2510-2310 cal BC a 2 σ y su final entre el 2115-1795 cal BC a 2 σ, convirtiéndose en el más reciente de los recintos de fosos peninsulares. La comparación con las dataciones existentes para otros tramos del Foso 4 invalida la pretensión de fechar la construcción de los fosos a partir de las dataciones obtenidas en los depósitos asociados a su base. Las secuencias temporalmente diferenciadas en la colmatación de diferentes tramos de un mismo foso sugiere que su configuración es más el resultado de agregados de segmentos que construcciones unitarias

    Eftilagimod alpha (a soluble LAG-3 protein) combined with pembrolizumab in second-line metastatic NSCLC refractory to anti–programmed cell death protein 1/programmed death-ligand 1-based therapy: final results from a phase 2 study

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    Introduction: Eftilagimod alpha (efti), a soluble lymphocyte activation gene-3 protein, triggers antigen-presenting cell and T-cell (CD4+ and CD8+) activation and helps overcome resistance to programmed cell death protein 1 or programmed cell death-ligand 1 (PD-(L)1) inhibitors. We assessed efti plus pembrolizumab in second-line anti–PD-(L)1-refractory metastatic patients with NSCLC. Methods: After confirmed progression on anti-PD-(L)1-based first-line therapy, patients received efti (30 mg subcutaneously every 2 weeks for eight 3-week cycles and then every 3 weeks for up to 54 weeks) plus pembrolizumab (200 mg intravenously every 3 weeks for up to 105 weeks). The primary endpoint was the objective response rate by modified Response Evaluation Criteria in Solid Tumors version 1.1 for immune-based therapies. Secondary endpoints included disease control rate, progression-free survival, overall survival (OS), and tolerability. Exploratory endpoints included tumor growth kinetics and predefined subgroup analyses. Programmed cell death-ligand 1 tumor proportion score was assessed centrally. Results: Thirty-six patients were enrolled from April 2019 to August 2021 using Simon’s two-stage design. Most patients (81.8%) had low or negative (&lt;50%) PD-(L)1 tumor proportion score. First-line therapy was anti–PD-(L)1-based for all patients, combined with chemotherapy for 66.7%. The confirmed objective response and disease control rates were 8.3% and 33.3%. The median progression-free survival was 2.1 months and the median OS was 9.9 months. Patients exhibiting high PD-(L)1 expression or acquired resistance to PD-(L)1 inhibitors revealed superior response and survival outcomes, and OS was closely correlated with disease control. No treatment-emergent adverse event led to permanent discontinuation of study treatment. Conclusions: Efti plus pembrolizumab was well-tolerated and revealed signs of antitumor activity in patients with NSCLC resistant to PD-(L)1 inhibitors, warranting further investigation. Trial registration number: NCT03625323
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