Infectious Diseases Associated With Renal Homotransplantation: I. Incidence, Types, and Predisposing Factors

Infectious diseases occurred in 26 of 30 renal homotransplantation patients and contributed to eight of the 12 deaths in this series. There were 52 infections, 17 occurring before and 35 after transplantation. Infections were produced primarily by staphylococci, Pseudomonas species, and the enteric gram-negative bacilli. Staphylococcal infections occurred in 17 of 19 carriers of this organism and in only one of 11 noncarriers. Thirty-three of the 35 postoperative infections followed the intensification of immunosuppressive therapy for treatment of attempted homograft rejection. Granulocytopenia, steroid-induced diabetes, and hypogammaglobulinemia, from suppressive drug therapy, routinely preceded the onset of these complications. The infections, largely of endogenous origin, occurred when the host's defense mechanisms were depressed. © 1964, American Medical Association. All rights reserved

Clinical experience with organ transplantation

The authors have had an exceptional experience in the transplantations of organs in humans. This paper clearly indicates the current status in this area of medical experimentation. © 1965 Southern Medical Association

2-D constrained Navier-Stokes equation and intermediate asymptotics

We introduce a modified version of the two-dimensional Navier-Stokes equation, preserving energy and momentum of inertia, which is motivated by the occurrence of different dissipation time scales and related to the gradient flow structure of the 2-D Navier-Stokes equation. The hope is to understand intermediate asymptotics. The analysis we present here is purely formal. A rigorous study of this equation will be done in a forthcoming paper

SPLENIC HOMOTRANSPLANTATION.

During the past 12 months, five clinical whole-organ splenic homotransplantations have been carried out with the objective of providing active immunologic tissue for the recipient patients. In one case with hypogammaglobulinemia, it was hoped that the transplanted tissue would alleviate a state of immunologic deficiency. In the other four, all of whom had terminal malignancies, the purpose was to superimpose a state of altered immunologic reactivity upon the host in the hope of thereby suppressing the inexorable growth of the neoplasms. As will be described, these procedures can now be judged in each instance to have been without benefit. Nevertheless, full documentation of the cases seems justified not only because of the many implications of transplantation of immunologically competent tissue, but also because of the potentially important observations made during the care of these patients. In addition, a full account will be presented of the supporting canine studies of splenic homotransplantation, inasmuch as many of the principles of clinical therapy and investigation derived from prior observations in the dog. The fact that it is possible to obtain viable splenic homografts in the dog for as long as two-thirds of a year without the production of runt disease or other harmful effects may have application in future research on bone marrow, other lymphoid, or hepatic homografts

On 2-switches and isomorphism classes

A 2-switch is an edge addition/deletion operation that changes adjacencies in the graph while preserving the degree of each vertex. A well known result states that graphs with the same degree sequence may be changed into each other via sequences of 2-switches. We show that if a 2-switch changes the isomorphism class of a graph, then it must take place in one of four configurations. We also present a sufficient condition for a 2-switch to change the isomorphism class of a graph. As consequences, we give a new characterization of matrogenic graphs and determine the largest hereditary graph family whose members are all the unique realizations (up to isomorphism) of their respective degree sequences.Comment: 11 pages, 6 figure

Isohemagglutinins of Graft Origin after ABO-Unmatched Liver Transplantation

THE increasing success of liver transplantation in recent years has provided an experimental model to study and document the hepatic synthesis of many plasma proteins.12345 The normal hepatobiliary tract has not been regarded as a major source of antibody,6,7 aside from the enteric IgA secreted from plasma into the biliary tree.8 Liver transplantation affords the opportunity to study the production of antibody to red cells. Recipient ABO incompatibility to the donor (a mismatched transplant, e.g., a group A liver transplanted into a group B recipient), although not absolutely contraindicated in liver transplantation, is avoided when possible. However, ABO-unmatched transplants (defined. © 1984, Massachusetts Medical Society. All rights reserved