Introduction of measures for segments and angles in a general absolute plane

AbstractTo an absolute plane (E,L,≡,α) in the general sense of Karzel et al. [Einführung in die Geometrie, UTB 184, Vandenhoeck, Göttingen, 1973, Section 16] there will be associated an ordered commutative group (W,+,<) such that (W,+) is a subgroup of the corresponding K-loop (E,+) of the absolute plane and a cyclic ordered commutative group (E1,·,ζ) where (E1,·) is isomorphic to a rotation group fixing a point. (W,+,<), resp. (E1,·,ζ), will serve to introduce a distance λ describing the congruence and satisfying the triangular inequality or resp. a measure μ for angles describing the congruence and conjugacy of angles

A new specific neuronal modulatory effect of nicotine: the functional cross talk between nicotinic and glutamate receptors

We here have addressed the topic of the cross-talk between receptors. We provide evidence supporting the co-localization and the functional interaction between nicotinic acetylcholine receptors and some glutamatergic receptors. The recruitment of nicotinic acetylcholine receptors dynamically and negatively modulates the function of both N-methyl-D-aspartic acid (NMDA) and ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors throughout their selective internalization. This dynamic control by cholinergic nicotinic system of NMDA and ?-AMPA receptors is operative even at very low concentrations of nicotine. Nicotinic and glutamatergic receptors have been both implicated in important neurological and psychiatric disorders such as Alzheimer’s and Parkinson’s disease, schizophrenia, and anxiety. Thus, a more extensive and detailed knowledge of this new modulatory role of nicotine may eventually enable us to develop specific therapeutic interventions for these pathologies

Interdisciplinary research. Measurement and assessment indicators

WP 06/13; In order to implement appropriate policies to face the difficulties and remove the obstacles that hinder interdisciplinary research, it is necessary to clarify how this ever broader and more dynamic portion of science works and which incentives best support the activities of scientists. Interdisciplinary studies are a peculiar aspect of the activities performed by researchers operating at the frontier of science, for instance in cutting-edge sectors. They might encompass fields of investigation that already exist, but they cannot be exclusively ascribed to any one of them. Abstract answers regarding the very unusual matters investigated by interdisciplinary research would make it extremely difficult to provide quantitative output measurements and evaluations. Yet, the shift from general abstract answers to specific empirical problems, which is the objective of most interdisciplinary research, turns out to be an advantage when assessing this type of research. Concentrating on problems and on approaching their solutions in objective quantitative terms can allow for output measurement and assessment also in the case of interdisciplinary research. This can be achieved by using precision and efficiency parameters able to provide public policies and entrepreneurial activities with content that is as clearly defined and as rigorous as that of specialist researc

Uno studio sull’innovazione nell’industria chimica

In our analysis, we have remembered the general result reached by studies on innovation of late, according to which innovation in manufacturing industry is a complex phenomenon and does not lend itself to be described and explained through simplistic analytical models. We have then taken clue from a variegated description of the firms’ innovative behaviour, based on several indicators of their innovativeness. Our results confirm the idea that remarkable differences exist between the two sub-sectors into which chemical industry is broken down: pharmaceutical and basic chemicals. As for policy implications, the close correlation between patents and basic-research expenditure suggests that the Italian Fund for basic research (FIRB) might be useful in order to promote innovation in chemical industry.Industria chimica; Innovazione; Ricerca

How could patient reported outcomes improve patient management in chronic myeloid leukemia?

Introduction: Patients reported outcome (PRO) are still under-used in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs), though data on the correlation between quality of life (QoL) and therapeutic efficacy are increasingly known. Chronic low-grade toxicities can reduce patient's QoL and negatively impact on adherence.Areas covered: This review will focus on the role of QoL questionnaires in patients with CML, receiving imatinib or newer TKIs (dasatinib, nilotinib, bosutinib, ponatinib). Physicians tend to underestimate the impact of TKI-related symptoms, in particular fatigue, that negatively affect QoL and can be a reason of poor adherence to therapy, with detrimental effect on long-term response. Few studies pointed out the role of PRO in CML, and there is paucity of questionnaires specifically designed for CML patients.Expert commentary: We recommend a wider use of PRO to join the pursuit of a rapid and deep responses with an optimization of QoL

Brief notes on the policies for science-based firms

WP 12/2004; One of the main reasons why the Italian industry’s R&amp;D activities lag behind those of its competitors is often suggested to be the very low weight of high technology firms in that productive system. Here, we propose a specific measure to correct this anomaly. It aims both to foster the industry’s R&amp;D and encourage a closer co-operation of public universities with private companies. This policy provision would serve a dual purpose: it could be seen as a means of fostering the co-operation between the public research sphere and industry; it could also be a way of financing the research universities do. We argue that, by submitting additional funding for university research to a judicious evaluation by private sector producers, Italy could increase its prospects of achieving economic returns on academic research

Classification of general absolute geometries with Lambert-Saccheri quadrangles

Without claiming any kind of continuity we show that an absolute geometry has either a singular, a hyperbolic or an elliptic congruence

Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols

AbstractThe Ca2+- and oxidative stress-induced mitochondrial permeability transition (MPT) plays an important role in phenomena ranging from tissue damage upon infarction to muscle wasting in some forms of dystrophy. The process is due to the activation of a large pore in the inner mitochondrial membrane. Anti-oxidants are considered a preventive and remedial tool, and mitochondria-targeted redox-active compounds have been developed. Plant polyphenols are generally considered as anti-oxidants, and thus candidates to the role of mitochondria-protecting agents. In patch-clamp experiments, easily oxidizable polyphenols induced closure of the MPT channel. In swelling experiments with suspensions of mitochondria, high (20–50 μM) concentrations of quercetin, the most efficient inhibitor, promoted instead the onset of the MPT. Chelators of Fe2+/3+ and Cu+/2+ ions counteracted this effect. Fluorescent indicators of superoxide production confirmed that quercetin potentiates O2− generation by isolated mitochondria and cultured cells. Since this was not affected by chelating Fe and Cu ions, the MPT-inducing effect can be ascribed to a “secondary”, metal ion-catalyzed production of ROS. These results are a direct demonstration of the ambivalent redox character of polyphenols. Their mode of action in vivo cannot be taken for granted, but needs to be experimentally verified