Role of neutron transfer processes on the 6Li+120Sn and 7Li+119Sn fusion reactions

The results concerning the study of 6 Li+ 120 Sn and 7 Li+ 119 Sn systems are presented. These two sistems are characterised by very similar structures of the interacting nuclei and by different Q-value for oneand two- neutron transfer. Our aim is to disentangle the possible effects due to the different n-transfer Q-values, at sub-barriers energies, by comparing the two fusion excitation function. In these experiments the fusion cross section has been measured by using a stack activation technique. No particular differences in the two fusion excitation functions have been observed. The influence of transfer channels on fusion cross-section has been object of investigations in the last years. In particular, the possible dependence of the fusion cross-section on the sign of the neutron transfer Q-value has been much debated in literature. The systematic approach used for the study of the Ca+Zr systems [1] provided relatively clear evidence of the relation between sub-barrier-cross section and the sign of the neutron transfer Q-value, in a model-independent way. According to experimenta

Halo effects on fusion cross section in 4,6He+64Zn collision around and below the Coulomb barrier

The structure of the halo nuclei is expected to influence the fusion mechanism at energies around and below the Coulomb barrier. Here new data of 4He+64Zn at sub-barrier energies are presented which cover the same energy region of previous measurements of 6He+64Zn. The fusion cross section was measured by using an activation technique where the radioactive evaporation residues produced in the reaction were identified by the X-ray emission which follows their electron capture decay. By comparing the two system, we observe an enhancement on the fusion cross section in the reaction induced by 6He, at energy below the Coulomb barrier. It is shown that this enhancement seems to be due to static properties of halo 2n 6He nucleus

Enhancement in the 6He+64Zn fusion cross section at energies around the barrier: static or dynamic effect?

A new measurement of fusion cross-section for the system 4 He+64 Zn was performed at sub-barrier energy in order to cover the same energy region of previous measurements of 6 He+64 Zn. The fusion cross-section was obtained using an activation technique. From the comparison of the two excitation functions an enhancement of the fusion cross section was observed, at energy below the Coulomb barrier, in the reaction induced by 6 He in respect to the one induced by 4 He

Heavy residue excitation functions for the collisions 6, 7Li + 64Zn near the Coulomb barrier

Excitation functions for the production of heavy residues have been measured for the collisions 6, 7Li+64Zn at energies around and below the Coulomb barrier. The cross sections for heavy residue production have been measured using an activation technique, detecting off-line the characteristic atomic x-rays emitted in the electron capture decay of the reaction products. The experimental relative yields of the residues have been compared with statistical model calculations performed by using the code cascade. Such a comparison suggests that heavy residue production is dominated by complete fusion at above-barrier energies, whereas different processes like incomplete fusion and/or transfer become dominant in the sub-barrier energy region. The heavy residue excitation function ratio between the 6Li- and 7Li-induced collisions shows an increasing trend as the energy decreases below the barrier

Ultrasound Effectiveness of Steroid Injection for hand Psoriatic Dactylitis: Results from a Longitudinal Observational Study

Introduction: To assess clinical and ultrasound effectiveness of steroid injection (local treatment, LT) into the digital flexor tendon sheath for the treatment of psoriatic dactylitis compared to systemic treatment (ST) alone. Methods: In this observational, multicentre, prospective study, 88 cases of symptomatic hand dactylitis were evaluated clinically and sonographically by high-frequency ultrasound (US) probe in both greyscale (GS) and power Doppler (PD). The presence of flexor tenosynovitis (FT), soft tissue oedema (STO), peritendon extensor inflammation and synovitis was assessed (including DACtylitis glObal Sonographic—DACTOS—score) before treatment, at 1-month (T1) and 3-months (T3) follow-up. LT was proposed to all patients. Patients refusing LT were treated with oral NSAIDs. Patients continued the same baseline csDMARDs and/or corticosteroid therapy during the whole follow-up period. US response was defined for DACTOS score < 3 and US remission for DACTOS score = 0. Results: At T3 evaluation the ST group showed a significantly higher persistence (grade > 1) of FT and STO (p < 0.001 for all) and MCP synovitis (p = 0.001). US remission was achieved only in the LT group (at T3 31% vs. 0, p < 0.001). The percentage of patients with DACTOS < 3 was significantly greater in the LT group compared with ST group, at both T1 (49% vs. 5%, p < 0.001) and T3 evaluation (76% vs. 7%, p < 0.001). In multiple conditional logistic regression analysis, the only factor associated with US remission was LT (T3 odds ratio = 41.21, p < 0.001). Conclusions: US confirmed the effectiveness of steroid injection for dactylitis by demonstrating that it involves the resolution of extra-articular inflammation, in particular FT and STO

Prospectus, September 22, 1982

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Efficacy and Drug Survival after Switching from Etanercept to the Biosimilar SB4: A Real-Life Long-Term Study

We evaluated the 3-year drug survival and efficacy of the biosimilar SB4/Benepali in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) patients, pre-viously treated with etanercept (ETA). Drug survival rate was calculated using the Kaplan\u2013Meier method and Cox proportional hazard models were developed to examine predictors of SB4 discontin-uation. 236 patients (120 RA, 80 PsA and 36 AS), aged 60.7 \ub1 13.8 years and with an ETA duration of 4.1 \ub1 3.4 years were included. The 3-year retention rate for SB4 was 94.4%, 88% and 86% in AS, RA and PsA patients, respectively, with no difference between groups. Patients without comorbid disease had higher retention rates vs. patients with comorbid disease (90% vs. 60%, p < 0.0001). Disease activity, as measured by DAS28, DAPSA and BASDAI remained stable over the 3 years. Comorbid disease (hazard ratio; HR: 4.06, p < 0.0001) and HAQ at baseline (HR: 2.42, p = 0.0024) significantly increased the risk of SB4 discontinuation, while previous ETA duration was negatively associated with SB4 discontinuation (HR: 0.97, p = 0.0064). Forty-one (17.4%) patients left the study due to the interruption of the SB4 treatment, 31 (75.6%) discontinued due to inefficacy and 10 (24.4%) due to adverse events. This real-life study confirms the similar efficacy profile of ETA with long-term retention and a good safety profile in inflammatory arthritis patients

MET currents and otoacoustic emissions from mice with a detached tectorial membrane indicate the extracellular matrix regulates Ca2+ near stereocilia

The tectorial membrane (TM) is an acellular structure of the cochlea that is attached to the stereociliary bundles of the outer hair cells (OHCs), electromotile cells that amplify motion of the cochlear partition and sharpen its frequency selectivity. Although the TM is essential for hearing, its role is still not fully understood. In Tecta/Tectb−/− double knockout mice, in which the TM is not coupled to the OHC stereocilia, hearing sensitivity is considerably reduced compared with that of wild‐type animals. In vivo, the OHC receptor potentials, assessed using cochlear microphonics, are symmetrical in both wild‐type and Tecta/Tectb−/− mice, indicating that the TM does not bias the hair bundle resting position. The functional maturation of hair cells is also unaffected in Tecta/Tectb−/− mice, and the resting open probability of the mechanoelectrical transducer (MET) channel reaches values of ∼50% when the hair bundles of mature OHCs are bathed in an endolymphatic‐like Ca2+ concentration (40 μM) in vitro. The resultant large MET current depolarizes OHCs to near –40 mV, a value that would allow optimal activation of the motor protein prestin and normal cochlear amplification. Although the set point of the OHC receptor potential transfer function in vivo may therefore be determined primarily by endolymphatic Ca2+ concentration, repetitive acoustic stimulation fails to produce adaptation of MET‐dependent otoacoustic emissions in vivo in the Tecta/Tectb−/− mice. Therefore, the TM is likely to contribute to the regulation of Ca2+ levels around the stereocilia, and thus adaptation of the OHC MET channel during prolonged sound stimulation

Comprehensive study of the reactions induced by 12C on 103Rh up to 33 MeV/nucleon

Abstract Fifty-three excitation functions for the production of radioactive residues in the interaction of 12C with 103Rh have been measured from the Coulomb barrier up to 400 MeV by means of the activation technique. These excitation functions have been analyzed considering complete fusion, incomplete fusion of 8Be and α-particle fragments and, above about 200 MeV, the transfer of either one proton or one neutron from 12C to 103Rh. The emission of pre-equilibrium particles during the thermalization of the excited composite nuclei formed in all these processes and, in the case of 8Be and α incomplete fusion, also the re-emission of α-particles after a mean-field interaction or a few interactions with the target nucleons have been taken into account