Shubnikov-de Haas oscillations spectrum of the strongly correlated quasi-2D organic metal (ET)8[Hg4Cl12(C6H5Br)]2 under pressure

Pressure dependence of the Shubnikov-de Haas (SdH) oscillations spectra of the quasi-two di- mensional organic metal (ET)8[Hg4Cl12(C6H5Br)]2 have been studied up to 1.1 GPa in pulsed magnetic fields of up to 54 T. According to band structure calculations, its Fermi surface can be regarded as a network of compensated orbits. The SdH spectra exhibit many Fourier components typical of such a network, most of them being forbidden in the framework of the semiclassical model. Their amplitude remains large in all the pressure range studied which likely rules out chemical potential oscillation as a dominant contribution to their origin, in agreement with recent calculations relevant to compensated Fermi liquids. In addition to a strong decrease of the magnetic breakdown field and effective masses, the latter being likely due to a reduction of the strength of electron correlations, a sizeable increase of the scattering rate is observed as the applied pressure increases. This latter point, which is at variance with data of most charge transfer salts is discussed in connection with pressure-induced features of the temperature dependence of the zero-field interlayer resistanceComment: Eur. Phys. J. B, in pres

Pressure dependence of the magnetoresistance oscillations spectrum of beta''-(BEDT-TTF)4(NH4)[Fe(C2O4)3].DMF

The pressure dependence of the interlayer magnetoresistance of the quasi-two dimensional organic metal beta''-(BEDT-TTF)4(NH4)[Fe(C2O4)3].DMF has been investigated up to 1 GPa in pulsed magnetic fields up to 55 T. The Shubnikov-de Haas oscillations spectra can be interpreted on the basis of three compensated orbits in all the pressure range studied, suggesting that the Fermi surface topology remains qualitatively the same as the applied pressure varies. In addition, all the observed frequencies, normalized to their value at ambient pressure, exhibit the same sizeable pressure dependence. Despite this behavior, which is at variance with that of numerous charge transfer salts based on the BEDT-TTF molecule, non-monotonous pressure-induced variations of parameters such as the scattering rate linked to the various detected orbits are observed.Comment: accepted for publication in Phys. Rev.

Status of the BMV experiment

In this contribution we present the status of the BMV experiment whose goal is to measure the vacuum magnetic birefringence

Critical doping for the onset of a two-band superconducting ground state in SrTiO3−δ_{3-\delta}

In doped SrTiO$_{3}$ superconductivity persists down to an exceptionally low concentration of mobile electrons. This restricts the relevant energy window and possible pairing scenarios. We present a study of quantum oscillations and superconducting transition temperature, $T_{c}$ as the carrier density is tuned from $10^{17}$ to $10^{20}$ $cm^{-3}$ and identify two critical doping levels corresponding to the filling thresholds of the upper bands. At the first critical doping, which separates the single-band and the two-band superconducting regimes in oxygen-deficient samples, the steady increase of T$_{c}$ with carrier concentration suddenly stops. Near this doping level, the energy dispersion in the lowest band displays a downward deviation from parabolic behavior. The results impose new constraints for microscopic pairing scenarios.Comment: 5 pages of main article and 4 pages of supplemen

Field-induced spin density wave in (TMTSF)2_2NO3_3

Interlayer magnetoresistance of the Bechgaard salt (TMTSF)$_2$NO$_3$ is investigated up to 50 teslas under pressures of a few kilobars. This compound, the Fermi surface of which is quasi two-dimensional at low temperature, is a semi metal under pressure. Nevertheless, a field-induced spin density wave is evidenced at 8.5 kbar above $\sim$ 20 T. This state is characterized by a drastically different spectrum of the quantum oscillations compared to the low pressure spin density wave state.Comment: to be published in Phys. Rev. B 71 (2005

Search for photon oscillations into massive particles

International audienceIn this paper, we present the final results of our experiment on photon-axion oscillations in the presence of a magnetic field, which took place at LULI (Laboratoire pour l'Utilisation des Lasers Intenses, Palaiseau, France). Our null measurement allowed us to exclude the existence of axions with inverse coupling constant $M>9.\times 10^5$ GeV for low axion masses and to improve the preceding BFRT limits by a factor 3 or more for axion masses $1.1\, \mbox{meV

A 30 T pulsed magnet with conical bore for synchrotron powder diffraction

International audienceWe report on the design, construction, and operation of a horizontal field, 30 T magnet system with a conical bore optimized for synchrotron x-ray powder diffraction. The magnet offers±31optical access downstream of the sample, which allows to measure a sufficiently large number of Debye rings for an accurate crystal structure analysis. Combined with a 290 kJ generator, magnetic field pulses of 60 ms length were generated in the magnet, with a rise time of 4.1 ms and a repetition rate of 6 pulses/h at 30 T. The coil is mounted inside a liquid nitrogen bath. A liquid helium flow cryostat reaches into the coil and allows sample temperature between 5 and 250 K. The setup was used on the European Synchrotron Radiation Facility beamlines ID20 and ID06

Survey of Activated FLT3 Signaling in Leukemia

Activating mutations of FMS-like tyrosine kinase-3 (FLT3) are found in approximately 30% of patients with acute myeloid leukemia (AML). FLT3 is therefore an attractive drug target. However, the molecular mechanisms by which FLT3 mutations lead to cell transformation in AML remain unclear. To develop a better understanding of FLT3 signaling as well as its downstream effectors, we performed detailed phosphoproteomic analysis of FLT3 signaling in human leukemia cells. We identified over 1000 tyrosine phosphorylation sites from about 750 proteins in both AML (wild type and mutant FLT3) and B cell acute lymphoblastic leukemia (normal and amplification of FLT3) cell lines. Furthermore, using stable isotope labeling by amino acids in cell culture (SILAC), we were able to quantified over 400 phosphorylation sites (pTyr, pSer, and pThr) that were responsive to FLT3 inhibition in FLT3 driven human leukemia cell lines. We also extended this phosphoproteomic analysis on bone marrow from primary AML patient samples, and identify over 200 tyrosine and 800 serine/threonine phosphorylation sites in vivo. This study showed that oncogenic FLT3 regulates proteins involving diverse cellular processes and affects multiple signaling pathways in human leukemia that we previously appreciated, such as Fc epsilon RI-mediated signaling, BCR, and CD40 signaling pathways. It provides a valuable resource for investigation of oncogenic FLT3 signaling in human leukemia

DMTs and Covid-19 severity in MS: a pooled analysis from Italy and France

We evaluated the effect of DMTs on Covid-19 severity in patients with MS, with a pooled-analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid-19 severity was assessed by multivariate ordinal-logistic models and pooled by a fixed-effect meta-analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti-CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid-19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled-analysis confirms an increased risk of severe Covid-19 in patients on anti-CD20 therapies and supports the protective role of interferon