7 research outputs found
Plasma homocysteine and the severity of heart failure in patients with previous myocardial infarction
Background: Homocysteine is considered to be a risk factor, or an indicator of risk, for the
development of cardiovascular disease. Little data is available on its significance in patients
with previous myocardial infarction. The aim of our study was to assess the plasma level of
homocysteine and its relationship with the severity of heart failure in patients with chronic
myocardial infarction.
Methods: We studied 144 patients with previous myocardial infarction. Patients were
divided into two groups according to the presence or absence of heart failure, as certified by
clinical evidence of heart failure and by echocardiographic criteria for left ventricular systolic
dysfunction.
Results: Of the patients with prior myocardial infarction (144; 63.6 ± 9.6 years) included
in the study, 65 had heart failure. The mean level of homocysteine was significantly higher in
the heart failure group (18.9 mmol/L) than in the non-heart failure group (14.1 mmol/L;
p ≤ 0.001). Our study demonstrated that there is a statistically significant correlation
between homocysteine plasma levels and the severity of heart failure in patients with prior
myocardial infarction. Homocysteine levels have proved to become higher with NYHA class
progression. A significant cross-sectional correlation has been assessed between homocysteine
and tissue Doppler echocardiography parameters.
Conclusions: Increased plasma homocysteine levels independently correlate with the severity
of heart failure in patients with chronic myocardial infarction. We suggest that homocysteine
can be used in clinical practice as a valuable heart failure risk marker in patients with
chronic myocardial infarction. (Cardiol J 2011; 18, 1: 55-62
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