Czynniki warunkujące wypoczynek nocny i jakość opieki pielęgniarskiej pacjenta oddziału neurologicznego

Introduction. The duration of hospitalization in a neurological ward depends on the medical diagnosis and the patient’s state of health. Because of the variety of symptoms from the nervous system, nurse practitioners provide 24 hours care for their patients, fulfilling their professional duties. The family is also included in the care of the patient during the day. At night, the patient is mainly under the care of a nurse, which on the one hand, is a period of sleep and rest, and on the other hand, the risk of health deficiencies is increased.Aim. The purpose of this paper is to present the patient’s opinion about the factors determining night rest in the ward and the quality of nursing care provided at night.Material and Methods. A diagnostic survey was the research method, and the survey was the technique applied. The tools applied consisted of: Author Survey Questionnaire and Care Satisfaction Scale (Newcastle). The study was performed in a group of 98 patients of the clinical neurological Clinic in Rzeszów. The study covered the factors negatively affecting the patient’s night time rest in hospital and the nurse’s assessment of nursing and therapeutic tasks performed during the night. Patients with the score exceeding 6 in the Hodgkinson test 6 were included in the study.Results. The factors hindering/disrupting the night rest were listed by the patients in the following order: snoring of other patients, pain, uncomfortable bed, morning temperature measurements, medical acts and others. The least disturbing factor was the staff’s talks. In assessing the quality of nursing care provided during the night, the highest scores were obtained by the following activities performed by nurses: satisfying needs to create a sense of security, providing medical care at scheduled time and satisfying the need for sleep and rest at night or the opportunity to talk to a nurse.Conclusions. 1) The discomfort caused by factors affecting the night rest in the assessment of the patient is on the average level. 2) Overall assessment of nursing care by patients in both aspects the “experience” of nursing care and “satisfaction” was high. (JNNN 2017;6(4):143–149)Wstęp. Czasookres hospitalizacji w oddziale neurologicznym jest uzależniony od rozpoznania lekarskiego oraz stanu zdrowia pacjenta. Ze względu na różnorodność objawów ze strony układu nerwowego pielęgniarki sprawując całodobową opiekę nad pacjentem realizują zadania wynikające z roli zawodowej. W ciągu dnia do opieki nad pacjentem włącza się także rodzina. W porze nocnej pacjent pozostaje głównie pod opieką pielęgniarki, stąd też jest to z jednej strony czas snu i wypoczynku, a z drugiej strony pora zwiększonego ryzyka wystąpienia deficytów w zdrowiu.Cel. Celem niniejszej pracy jest ukazanie opinii pacjenta na temat czynników warunkujących wypoczynek nocny w oddziale i ocena jakości opieki pielęgniarskiej świadczonej w porze nocnej.Materiał i metody. Metodą badawczą był sondaż diagnostyczny, techniką ankieta. Narzędziem wykorzystanym w pracy były: Autorski Kwestionariusz Ankiety oraz Skala Zadowolenia z Pielęgnacji (Newcastle). Badanie przeprowadzono w grupie 98 pacjentów klinik neurologicznych Szpitali Klinicznych miasta Rzeszowa. Przedmiotem badań były czynniki negatywnie wpływające na wypoczynek nocny pacjenta w szpitalu oraz ocena realizacji zadań opiekuńczych i terapeutycznych realizowanych w porze nocnej przez pielęgniarki. Do badań zakwalifikowano pacjentów, którzy w teście Hodgkinsona uzyskali powyżej 6.Wyniki. Wśród czynników utrudniających/zakłócających wypoczynek nocny pacjenci wymieniali w kolejności: chrapanie innych pacjentów, dolegliwości bólowe, niewygodne łóżko, poranny pomiar temperatury, czynności medyczne i inne. Najmniej zakłócającym czynnikiem były rozmowy personelu. W ocenie jakości opieki pielęgniarskiej świadczonej w porze nocnej najwyższe oceny uzyskały takie świadczenia pielęgniarskie jak: zaspokajanie potrzeb w zakresie jedzenia i picia, stworzenie poczucia bezpieczeństwa, realizacja opieki medycznej w zaplanowanym czasie, nocnego zaspokajanie potrzeby snu i wypoczynku nocnego czy też możliwości rozmowy z pielęgniarką.Wnioski. 1) Uciążliwość czynników wpływających negatywnie na wypoczynek nocny w ocenie pacjenta jest na poziomie średnim. 2) Całościowa ocena opieki pielęgniarskiej przez pacjentów zarówno w aspekcie „doświadczeń” z opieki pielęgniarskiej jak i „satysfakcji” była wysoka. (PNN 2017;6(4):143–149

Bioorganic Chemistry: Current and Future Perspectives

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Application of molecularly imprinted polymers in an analytical chiral separation and analysis

Over the last two decades the process of development and application of a new types of molecular imprinted polymer (MIP) sorbents in the field of analytical chemistry have been widely described in the literature. One of the new trends in analytical chemistry practice is the use of new types of MIP sorbents as specific sorption materials constituting the stationary phase in advanced separation techniques. The following review paper contains comprehensive information about the application of a specific and well defined MIP sorbents (with the data base in the paper about the reagents used in MIP preparation process) as stationary phases in separation techniques including high performance liquid chromatography and capillary electrochromatography. Coverage includes newly created types of stationary phases (MIP sorbents) used for chiral recognition, with the focus on applications in enantioselective separation

POM/EVA Blends with Future Utility in Fused Deposition Modeling

Polyoxymethylene (POM) is one of the most popular thermoplastic polymers used in the industry. Therefore, the interest in its potential applications in rapid prototyping is understandable. Nevertheless, its low dimensional stability causes the warping of 3D prints, limiting its applications. This research aimed to evaluate the effects of POM modification with ethylene-vinyl acetate (EVA) (2.5, 5.0, and 7.5 wt.%) on its processing (by melt flow index), structure (by X-ray microcomputed tomography), and properties (by static tensile tests, surface resistance, contact angle measurements, differential scanning calorimetry, and thermogravimetric analysis), as well as very rarely analyzed emissions of volatile organic compounds (VOCs) (by headspace analysis). Performed modifications decreased stiffness and strength of the material, simultaneously enhancing its ductility, which simultaneously increased the toughness even by more than 50% for 7.5 wt.% EVA loading. Such an effect was related to an improved linear flow rate resulting in a lack of defects inside the samples. The decrease of the melting temperature and the slight increase of thermal stability after the addition of EVA broadened the processing window for 3D printing. The 3D printing trials on two different printers showed that the addition of EVA copolymer increased the possibility of a successful print without defects, giving space for further development

Antiviral, antimicrobial and antibiofilm activity of selenoesters and selenoanhydrides

Selenoesters and the selenium isostere of phthalic anhydride are bioactive selenium compounds with a reported promising activity in cancer, both due to their cytotoxicity and capacity to reverse multidrug resistance. Herein we evaluate the antiviral, the biofilm inhibitory, the antibacterial and the antifungal activities of these compounds. The selenoanhydride and 7 out of the 10 selenoesters were especially potent antiviral agents in Vero cells infected with herpes simplex virus-2 (HSV-2). In addition, the tested selenium derivatives showed interesting antibiofilm activity against Staphylococcus aureus and Salmonella enterica serovar Typhimurium, as well as a moderate antifungal activity in resistant strains of Candida spp. They were inactive against anaerobes, which may indicate that the mechanism of action of these derivatives depends on the presence of oxygen. The capacity to inhibit the bacterial biofilm can be of particular interest in the treatment of nosocomial infections and in the coating of surfaces of prostheses. Finally, the potent antiviral activity observed converts these selenium derivatives into promising antiviral agents with potential medical applications.The study was supported by the project SZTE ÁOK-KKA 2018/270-62-2 of the University of Szeged, Faculty of Medicine. Gabriella Spengler was also supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences. The authors of this paper received funding from the Márton Áron Research Programme financed by the Hungarian Ministry of Foreign Aairs and Trade. AK was supported by the New National Excellence Program (ÚNKP-18-3) of the Ministry of Human Capacities of Hungary and by the Campus mundi short-study program of the Tempus Public Foundation. EDA was supported by the Spanish “Consejo Superior de Investigaciones Científicas” (201780I027) (CSIC, Spanish National Research Council). CSM wishes to express gratitude to UNED-Pamplona, Fundación Bancaria “La Caixa”, and “Fundación Caja Navarra” for financial support for the project. JMAB and HEM are supported by a BBSRC David Phillips Fellowship to JMAB (BB/M02623X/1)

Chalcogen-Varied Imidazolone Derivatives as Antibiotic Resistance Breakers in Staphylococcus aureus Strains

In this study, a search for new therapeutic agents that may improve the antibacterial activity of conventional antibiotics and help to successfully overcome methicillin-resistant Staphylococcus aureus (MRSA) infections has been conducted. The purpose of this work was to extend the scope of our preliminary studies and to evaluate the adjuvant potency of new derivatives in a set of S. aureus clinical isolates. The study confirmed the high efficacy of piperazine derivatives of 5-arylideneimidazol-4-one (7–9) tested previously, and it enabled the authors to identify even more efficient modulators of bacterial resistance among new analogs. The greatest capacity to enhance oxacillin activity was determined for 1-benzhydrylpiperazine 5-spirofluorenehydantoin derivative (13) which, at concentrations as low as 0.0625 mM, restores the effectiveness of β-lactam antibiotics against MRSA strains. In silico studies showed that the probable mechanism of action of 13 is related to the binding of the molecule with the allosteric site of PBP2a. Interestingly, thiazole derivatives tested were shown to act as both oxacillin and erythromycin conjugators in S. aureus isolates, suggesting a complex mode of action (i.e., influence on the Msr(A) efflux pump). This high enhancer activity indicates the high potential of imidazolones to become commercially available antibiotic adjuvants