Guía general de manejo de plagas en el cultivo de algodón en Colombia: segunda parte.

Algodó

Guía general de manejo de plagas en el cultivo de algodón en Colombia: primera parte.

Algodó

Guía general de manejo de plagas en el cultivo de algodón en Colombia: última parte.

Algodó

Gene therapy with mesenchymal stem cells expressing IFN-ß ameliorates neuroinflammation in experimental models of multiple sclerosis

Background and purpose: Recombinant IFN-ß is one of the first-line treatments in multiple sclerosis (MS), despite its lack of efficacy in some patients. In this context, mesenchymal stem cells (MSCs) represent a promising therapeutic alternative due to their immunomodulatory properties and multipotency. Moreover, by taking advantage of their pathotropism, these cells can be genetically modified to be used as carriers for delivering or secreting therapeutic drugs into injured tissues. Here, we report the therapeutic effect of systemic delivery of adipose-derived MSCs (AdMSCs), transduced with the IFN-β gene, into mice with experimental autoimmune encephalomyelitis (EAE). Experimental approach: Relapsing-remitting and chronic progressive EAE were induced in mice. Cells were injected i.v. Disease severity, inflammation and tissue damage were assessed clinically, by flow cytometry of spleens and histopathological evaluation of the CNS respectively. Key results: Genetic engineering did not modify the biological characteristics of these AdMSCs (morphology, growth rate, immunophenotype and multipotency). Furthermore, the transduction of IFN-ß to AdMSCs maintained and, in some cases, enhanced the functional properties of AdMSCs by ameliorating the symptoms of MS in EAE models and by decreasing indications of peripheral and central neuro-inflammation. Conclusion and implications: Gene therapy was found to be more effective than cell therapy in ameliorating several clinical parameters in both EAE models, presumably due to the continuous expression of IFN-β. Furthermore, it has significant advantages over AdMSC therapy, and also over systemic IFN-ß treatment, by providing long-term expression of the cytokine at therapeutic concentrations and reducing the frequency of injections, while minimizing dose-limiting side effects

Aprendizaje en semiología radiológica para Tecnólogos en Radiología de la Fundación Universitaria del Área Andina, mediante una herramienta informática

La Semiología es una materia compleja que se enseña desde diversas metodologías, lo cual la hace de alto esfuerzo académico para los estudiantes que la requieren en el desarrollo de su actividad. Se ha encontrado que la literatura sobre Semiología Radiológica está dirigida al Médico Radiólogo, lo cual genera un inconveniente para el Tecnólogo en Radiología debido al enfoque, extensión y profundidad de los temas encaminados al diagnóstico y el tratamiento. El uso de las Tecnologías de Información y Comunicación (TIC), facilitan a los docentes la enseñanza de la semiología, y de esta manera el aprendizaje de esta para los estudiantes, simplificando así la comprensión de la información y el acceso a la misma. Por medio de esta investigación se plantea que, a partir de la implementación de la herramienta informática se producirán diferencias significativas entre el postest y el pretest (intra-grupos) y los sujetos de un grupo experimental

Effectiveness of early warning scores for early severity assessment in outpatient emergency care : a systematic review

Edited by Prof. Sandra C. ButtigiegBackground and Objectives: Patient assessment and possible deterioration prediction are a healthcare priority. Increasing demand for outpatient emergency care services requires the implementation of simple, quick, and effective systems of patient evaluation and stratification. The purpose of this review is to identify the most effective Early Warning Score (EWS) for the early detection of the risk of complications when screening emergency outpatients for a potentially serious condition.Materials and Methods: Systematic review of the bibliography made in 2022. Scientific articles in Spanish and English were collected from the databases and search engines of Pubmed, Cochrane, and Dialnet, which were published between 2017 and 2021 about EWSs and their capacity to predict complications.Results: For analysis eleven articles were selected. Eight dealt with the application of different early warning scores in outpatient situations, concluding that all the scoring systems they studied were applicable. Three evaluated the predictive ability of various scoring systems and found no significant differences in their results. The eight articles evaluated the suitability of NEWS/NEWS2 to outpatient conditions and concluded it was the most suitable in pre-hospital emergency settings.Conclusions: The early warning scores that were studied can be applied at the pre-hospital level, as they can predict patient mortality in the short term (24 or 48 h) and support clinical patient evaluation and medical decision making. Among them, NEWS2 is the most suitable for screening potentially deteriorating medical emergency outpatients.peer-reviewe

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Prevalencia de trastornos mentales en usuarios de consulta psicológica en una universidad colombiana

This is a prevalence study of the mental disorders on psychological counseling users. A sample of 103 outpatients who were administered the M.I.N.I test was used. The outcome showed that 70.6% of the patients had manifested mental disorders once or more in their lifetime, with mood disorders having more prevalence, followed by anxiety disorders, and non-alcoholic substance use. The disorders with greater prevalence in woman were depressive disorders, anxiety disorders, social phobia, and hypomania. For men it was found that disorders related to non-alcoholic substance abuse, depression, anxiety, mania, alcohol abuse, and dependence were more prevalent.Este es un estudio de la prevalencia de los trastornos mentales de los usuarios del servicio psicológico de una Universidad. Incluye una muestra de 103 consultantes voluntarios a los que se les aplicó el instrumento de evaluación M.I.N.I. Los resultados mostraron que el 70,6% de la población estudiada reportó haber presentado algún trastorno mental alguna vez en la vida, con mayor prevalencia los de estado de ánimo, seguido de los de ansiedad y los asociados al uso de sustancias no alcohólicas. Los trastornos de mayor prevalencia encontrados en las mujeres fueron en su orden: trastorno depresivo, de angustia, fobia social, y en los hombres: trastorno asociado al uso de sustancias no alcohólicas, trastornos depresivos, manía pasada, trastorno de ansiedad y abuso y dependencia de alcohol respectivamente

Prevalence of mental disorders in users of psychological consultation in a Colombian university

Este es un estudio de la prevalencia de los trastornos mentales de los usuarios del servicio psicológico de una Universidad. Incluye una muestra de 103 consultantes voluntarios a los que se les aplicó el instrumento de eva-luación M.I.N.I. Los resultados mostraron que el 70,6% de la población estudiada reportó haber presentado algún trastorno mental alguna vez en la vida, con mayor preva-lencia los de estado de ánimo, seguido de los de ansiedad y los asociados al uso de sustancias no alcohólicas. Los trastornos de mayor prevalencia encontrados en las muje-res fueron en su orden: trastorno depresivo, de angustia, fobia social, y en los hombres: trastorno asociado al uso de sustancias no alcohólicas, trastornos depresivos, manía pasada, trastorno de ansiedad y abuso y dependencia de alcohol respectivamenteThis is a prevalence study of the mental disorders on ps-ychological counseling users. A sample of 103 outpatients who were administered the M.I.N.I test was used. The outcome showed that 70.6% of the patients had manifested mental disorders once or more in their lifetime, with mood disorders having more prevalence, followed by anxiety disorders, and non-alcoholic substance use. The disorders with greater prevalence in woman were depressive disor-ders, anxiety disorders, social phobia, and hypomania. For men it was found that disorders related to non-alcoholic substance abuse, depression, anxiety, mania, alcohol abuse, and dependence were more prevalen