Alcance y tutela de los derechos básicos de los consumidores y usuarios en el marco del RDL 1/2007

[ES] El objeto de estudio del presente trabajo es investigar sobre el Derecho de consumo. Pretendemos conocer cómo se origina la necesidad de generar una normativa sobre esta materia. El objeto a analizar será la normativa y legislación vigente, así como el origen y desarrollo de la misma a nivel estatal, autonómico y local. De acuerdo con el objeto de estudio planteado, nuestro objetivo será llegar a comprender si la legislación llega realmente a aquellos para quien está diseñada, es decir, los consumidores y los usuarios. Recrearemos los casos en los cuales el consumidor o usuario puede serle útil dicha legislación, y comprobaremos si en la práctica real, es decir, mediante sentencias actuales la legislación responde realmente a las necesidades planteadas. También será de vital importancia glosar los actores que intervienen en el objeto de estudio, no solo hablaremos de consumidores y usuarios, sino también de proveedores, clientes, empresarios y productores. Al mismo tiempo para tener mayor conocimiento sobre el objeto de estudio, indagaremos en las dimensiones privada y pública del Derecho del consumo. Finalmente ampliaremos nuestro objeto de estudio analizando cada Derecho que los consumidores y usuarios tienen actualmente en la legislación vigente, y como objetivo pragmático crearemos una guía de uso y un decálogo para los usuarios y consumidores.[EN] The work will address the application of RDL 1/2007 (General Law for the Defense of Consumers and Users), from the perspective of final consumer protection of goods and services, focusing on the study of the content of Fundamental rights of the consumerTarín Sánchez, MO. (2017). Alcance y tutela de los derechos básicos de los consumidores y usuarios en el marco del RDL 1/2007. http://hdl.handle.net/10251/89756TFG

Morpho-physiological characteristics of corn (Zea mays L.) affected by drought during its vegetative stage

Objective: To evaluate the response corn hybrids have on their growth of aerial and root parts, transpiration,and water use efficiency during their early vegetative stage in irrigation and drought conditions.Design/methodology/approach: A randomized complete block design with a factorial arrangement, threerepetitions, three corn hybrids and two humidity levels were used. The evaluated variables were: plant height,leaf area, root length, dry weight of the aerial and root part of the plants, efficiency in the water use and totalplant transpiration.Results: The leaf area and dry weight data of the aerial parts of the assessed plants were greater in irrigationthan in drought; in contrast, root length, dry root weight and water use efficiency were higher in drought. SV 3245 registered a higher total transpiration per plant; SV 3243 and ASGROW 7543 showed higher dry weight in their aerial parts; ASGROW 7543 accumulated a greater dry weight at their roots and was more water usage efficient. The experiments indicated interaction for root length, dry root weight and efficiency in water use.Limitations on study/implications: The drought caused seedlings’ death at 28 days after sowing (dds), therefore, it was not possible to continue the evaluations from then on.Findings/conclusions: The drought decreased the growth of the aerial parts of the plants and increased the root system and efficiency in their water usage

Impact of measurable residual disease by decentralized flow cytometry: a PETHEMA real-world study in 1076 patients with acute myeloid leukemia

The role of decentralized assessment of measurable residual disease (MRD) for risk stratification in acute myeloid leukemia (AML) remains largely unknown, and so it does which methodological aspects are critical to empower the evaluation of MRD with prognostic significance, particularly if using multiparameter flow cytometry (MFC). We analyzed 1076 AML patients in first remission after induction chemotherapy, in whom MRD was evaluated by MFC in local laboratories of 60 Hospitals participating in the PETHEMA registry. We also conducted a survey on technical aspects of MRD testing to determine the impact of methodological heterogeneity in the prognostic value of MFC. Our results confirmed the recommended cutoff of 0.1% to discriminate patients with significantly different cumulative-incidence of relapse (-CIR- HR:0.71, P < 0.001) and overall survival (HR: 0.73, P = 0.001), but uncovered the limited prognostic value of MFC based MRD in multivariate and recursive partitioning models including other clinical, genetic and treatment related factors. Virtually all aspects related with methodological, interpretation, and reporting of MFC based MRD testing impacted in its ability to discriminate patients with different CIR. Thus, this study demonstrated that “real-world” assessment of MRD using MFC is prognostic in patients at first remission, and urges greater standardization for improved risk-stratification toward clinical decisions in AML.This study was supported by the Centro de Investigación Biomédica en Red – Área de Oncología - del Instituto de Salud Carlos III (CIBERONC; CB16/12/00369, CB16/12/00233, CB16/12/00284 and CB16/12/00400), Instituto de Salud Carlos III/Subdirección General de Investigación Sanitaria (FIS No. PI16/01661, PI16/00517 and PI18/01946), Gerencia Regional de Salud de CyL (GRS 1346/A/16) and the Plan de Investigación de la Universidad de Navarra (PIUNA 2014-18). This study was supported internationally by the Cancer Research UK, FCAECC and AIRC under the Accelerator Award Program EDITOR

Enzyme Promiscuity in Enolase Superfamily. Theoretical Study of o-Succinylbenzoate Synthase Using QM/MM Methods

The promiscuous activity of the enzyme o-succinylbenzoate synthase (OSBS) from the actinobacteria Amycolatopsis is investigated by means of QM/MM methods, using both density functional theory and semiempirical Hamiltonians. This enzyme catalyzes not only the dehydration of 2-succinyl-6R-hydroxy-2,4-cyclohexadiene-1R-carboxylate but also catalyzes racemization of different acylamino acids, with N-succinyl-R-phenylglycine being the best substrate. We investigated the molecular mechanisms for both reactions exploring the potential energy surface. Then, molecular dynamics simulations were performed to obtain the free energy profiles and the averaged interaction energies of enzymatic residues with the reacting system. Our results confirm the plausibility of the reaction mechanisms proposed in the literature, with a good agreement between theoretical and experimentally derived activation free energies. Our simulations unravel the role played by the different residues in each of the two possible reactions. The presence of flexible loops in the active site and the selection of structural modifications in the substrate seem to be key elements to promote the promiscuity of this enzyme.This work was supported by the Spanish Ministerio de Economia y Competitividad project CTQ2012-36253-C03-03 ́ and FEDER funds. K.S. thanks the Polish National Science Center (NCN) for Grant 2011/02/A/ST4/00246. The authors acknowledge computational facilities of the Servei d’Informatica ̀ de la Universitat de Valencia in the ̀ “Tirant” supercomputer, which is part of the Spanish Supercomputing Network

Profesorado : revista de curriculum y formación del profesorado

Monográfico con el título: 'Ambientalización curricular y sostenibilidad: nuevos retos de profesionalización docente'. Resumen basado en el de la publicaciónSe presenta una investigación de carácter cualitativo que pretende dar respuestas al diagnóstico compartido sobre el déficit en la formación de los equipos educativos en relación a la 'ambientalización' curricular. Se presenta un modelo de formación que se ha implementado en una actividad formativa dirigida a docentes de Educación Primaria y Secundaria y a asesores en educación ambiental pertenecientes a la Xarxa d'Escoles per a la Sostenibilitat de Catalunya. El modelo tiene como finalidad salvar la distancia entre el planteamiento ideológico de la educación ambiental y su concreción práctica en las aulas que a menudo constituye un obstáculo para la 'ambientalización' curricular. Para ello, la propuesta formativa se fundamenta en el concepto de idea de alto nivel y su conexión con la práctica que se ha concretado en la determinación de cuatro esferas: conceptual, creativa, didáctica y de investigación. Se concluye que el modelo propuesto es una forma coherente, sólida y rigurosa de abordar la 'ambientalización' curricular.AndalucíaES

La revisión de las calificaciones obtenidas por el alumnado durante la evaluación: problemas detectados y propuestas de mejora

La revisión de exámenes constituye una de las fases más clásicas del proceso de evaluación, tradicionalmente ingrata tanto para el alumnado como para el profesorado, no exenta de problemática, y sobre la que no se ha detenido suficientemente la atención

La revisión de las calificaciones obtenidas por el alumnado durante la evaluación: problemas detectados y propuestas de mejora

La revisión de exámenes constituye una de las fases más clásicas del proceso de evaluación, tradicionalmente ingrata tanto para el alumnado como para el profesorado, no exenta de problemática, y sobre la que no se ha detenido suficientemente la atención

El desarrollo del pensamiento científico-técnico en educación primaria

Se presentan nueve exposiciones recogidas en la colección Aulas de verano que ofrece el Instituto Superior de Formación y Recursos en red para el Profesorado, y que fueron desarrolladas en el curso de formación del profesorado de Educación Primaria que se celebró en la Universidad Internacional Menéndez Pelayo de Santander, cuyo objetivo es incentivar y promover acciones, actividades y prácticas educativas de interés para los profesores de educación primaria. Mediante diferentes proyectos prácticos ya realizados en las aulas se hace un repaso por distintos aspectos cotidianos como la alimentación, la electricidad, el agua o la energía, de tal manera que el alumno aprenda y se familiarice con las características y cualidades que estos temas poseen.MadridBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

Trends in Hospital Admissions and Death Causes in Patients with Systemic Lupus Erythematosus: Spanish National Registry

Background: the admission and death causes of SLE patients might have changed over the last years. Methods: Analysis of the Spanish National Hospital Discharge database. All individuals admitted with SLE, according to ICD-9, were selected. The following five admission categories were considered: SLE, cardiovascular disease (CVD), neoplasm, infection, and venous-thromboembolic disease (VTED), along four periods of time (1997&ndash;2000, 2001&ndash;2005, 2006&ndash;2010, and 2011&ndash;2015). Results: The admissions (99,859) from 43.432 patients with SLE were included. The absolute number of admissions increased from 15,807 in 1997&ndash;2000 to 31,977 in 2011&ndash;2015. SLE decreased as a cause of admission (from 47.1% to 20.8%, p &lt; 0.001), while other categories increased over the time, as follows: 5% to 8.6% for CVD, 8.2% to 13% for infection, and 1.4% to 5.5% for neoplasm (p &lt; 0.001 for all). The admission mortality rate rose from 2.22% to 3.06% (p &lt; 0.001) and the causes of death evolved in parallel with the admission categories. A significant trend to older age was observed over time in the overall population and deceased patients (p &lt; 0.001). Conclusions: Better control of SLE over the past two decades has led to a decrease in early admissions, and disease chronification. As a counterpart, CVD, infections, and neoplasm have become the main causes of admissions and mortality

Density assessment and reporting for Phlebotomus perniciosus and other sand fy species in periurban residential estates in Spain

© 2021 the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/ This document is the Accepted Manuscript version of a Published Work that appeared in final form in Parasitology Research. To access the final edited and published work see https://doi.org/10.1007/s00436-021-07270-0Green periurban residential areas in Mediterranean countries have flourished in the last decades and become foci for leishmaniasis. To remedy the absence of information on vector ecology in these environments, we examined phlebotomine sand fly distribution in 29 sites in Murcia City over a 3-year period, including the plots of 20 detached houses and nine non-urbanized sites nearby. We collected 5,066 specimens from five species using "sticky" interception and light attraction traps. The relative frequency of the main Leishmania infantum vector Phlebotomus perniciosus in these traps was 32% and 63%, respectively. Sand fly density was widely variable spatially and temporally and greatest in non-urbanized sites, particularly in caves and abandoned buildings close to domestic animal holdings. Phlebotomus perniciosus density in house plots was positively correlated with those in non-urbanized sites, greatest in larger properties with extensive vegetation and non-permanently lived, but not associated to dog presence or a history of canine leishmaniasis. Within house plots, sand fly density was highest in traps closest to walls. Furthermore, the study provides a guideline for insect density assessment and reporting and is envisioned as a building block towards the development of a pan-European database for robust investigation of environmental determinants of sand fly distribution