Inmunohistochemical detection of mastocytes in tissue from patients with actinic prurigo

Background: Actinic prurigo (AP) is a type of photodermatosis, the pathophysiology of which has not been determined. AP has been suggested to be a hypersensitivity reaction to the presence of eosinophils and the local production of IgE. Material and Methods: Descriptive study, using paraffin blocks of tissue that have been diagnosed with AP from the Dermopathology department, Hospital General Dr. Manuel Gea González. In 66 blocks from 63 patients, eosinophils were identified by hematoxylin and eosin staining, and mastocytes were labeled by immunohistochemistry. Three random microphotographs (40x) were used, and cell counts were calculated as the mean count in the 3 microphotographs. Results: Forty cases (63.5%) were female, and 23 (36.5%) were male. The mean age was 26.49 ±14.09 years; regarding the evolution time of the disease, the average was 11.93 years ±11.39. In 38 of 63 cases (60%), the lip, skin, and conjunctiva were affected clinically. In 22 of 63 cases (34%), AP cheilitis was the sole manifestation, and in 4 of 63 cases (6%), there were lesions in the skin and conjunctiva. The mean eosinophil count was 9 per case, the average number of mastocytes/field was 28.48 (range 0 to 66) Kruskal-W allis p =0.001. Conclusions: There are elements in AP that mediate the reaction of hypersensitivity type IV b, necessitating the identification of triggering factors

Cultura y sociedad en movimiento

La presente compilación de textos, que aborda temáticas diversas sobre cultura y sociedad, es corolario de un esfuerzo compartido de profesores investigadores y alumnos de licenciatura y posgrado con el fin de dar a conocer resultados de las investigaciones que se están realizando en el organismo académico, incluyendo, por supuesto, otros trabajos llevados a cabo por colegas de instituciones y disciplinas afines; de esta manera se fortalecen los cuerpos académicos y se promueven las líneas de generación y aplicación del conocimiento de éstos, evidenciando algunos campos de conocimiento de la antropología.Como es manifiesto, la obra en su conjunto aborda distintos temas desde diversas perspectivas epistemológicas y teórico-conceptuales. Constituye un trabajo plural que articula la perspectiva antropológica, con otras lentes disciplinares. Cuerpo, agricultura, desigualdad y bienestar se entrelazan como ejes en principio divergentes, que hallan en lo sociocultural un elemento común de análisis. Así, los textos aquí englobados tienen la expectativa de aportar en la discusión contemporánea de viejos y nuevos derroteros de interés antropológico, y social en general

The Hair Shedding Visual Scale: A Quick Tool to Assess Hair Loss in Women

Hair shedding is a common consequence of the normal hair cycle that changes with internal and external factors. Female pattern hair loss (FPHL) is difficult to assess in terms of shedding severity as the conscious perception of hair shedding varies according to each individual, and most utilized methods are semi-invasive or very time consuming. In this study, we establish and validate a hair-shedding scale for women with thick hair of different lengths. A visual analog scale was developed for thick hair of short, medium, and long lengths by dividing a bundle of hairs of each length into nine piles of increasing hair amount that were then photographed and arranged in order of size. Twenty women with no FPHL with each length of hair (60 total) were asked to select the photographed hair bundle that best correlated with the amount of hair they shed on an average day. A total of 94 women with FPHL with excessive shedding were then asked to repeat the same process. Women with no FPHL and short, medium and long hair had mean shedding scores of 2.5, 2.35 and 2.4, respectively. Women with FPHL and short, medium and long hair had mean shedding scores of 7.25, 7.0 and 7.14, respectively. Statistically significant Spearman's ρ coefficient and κ coefficient demonstrated correlation and inter-observer reliability. Our results show that women with FPHL not only shed considerable hair more than women with no FPHL, but that this hair-shedding visual scale is a fast and effective method of evaluating hair-shedding amounts in an office setting

Quantification of Hair Follicles in the Scalp in Mexican Mestizo Population

Introduction: There are no reports of the density of hair follicles in the scalp of Mexican mestizo population, necessitating the determination of normal references values for this population compared with other ethnic groups. Objective: To determine the average hair follicle count on the scalp in Mexican mestizo population. Materials and Methods: A total of 50 scalp samples (25 men and 25 women) from Mexican mestizo individuals aged between 19 and 60 years, with no clinical evidence of hair disease, obtained by biopsy punch at General Hospital “Dr. Manuel Gea González” were collected over 2 years. The total follicular density, vellus and terminal hair follicles, and the percentage in anagen and catagen-telogen phase were measured. χ2 was used as the basic statistical test. Results: The mean number of total hair follicles in our Mexican mestizo population was 23.2 ± 4.2, which is lower compared with Thais, Iranians, and Caucasians. However, the ratio of terminal and vellus hair follicles was higher than in Thais, Caucasians, and African-Americans. The percentage of terminal hairs in anagen phase was lower than in the other populations, and higher in telogen, without exceeding 15%, established as the normal reference value. There was an association between sex and terminal hairs in telogen phase (p < 0.05). The average follicular density per mm2 was slightly higher compared with AfricanAmericans and Asians. Women had more terminal hairs than men. Conclusions: The density of total follicles is lower in the Mexican mestizo population compared with Iranians, Thais, and Caucasians. However, the greater number of terminal hairs compared to vellus hairs gives the appearance of greater overall volume. The results of this study can be used as a reference for diseases of the scalp in the Mexican population

Frontal Fibrosing Alopecia Severity Index: A Trichoscopic Visual Scale That Correlates Thickness of Peripilar Casts with Severity of Inflammatory Changes at Pathology

Frontal fibrosing alopecia (FFA) is a scarring alopecia that mainly affects postmenopausal women characterized by recession of the frontotemporal hairline and eyebrow loss. Current techniques to assess FFA activity are limited and involve noninvasive tools that assess disease progression or an invasive technique such as scalp biopsies. However, since progression of FFA is very slow, it is very important to develop a noninvasive technique to assess disease activity to monitor treatment response. To provide a standardized and objective method to assess FFA activity. We evaluated the correlation between trichoscopy and pathological features (degree of lymphocytic infiltration) in 20 dermoscopy-guided biopsies of FFA. At trichoscopy, we divided the severity of peripilar casts into 3 grades according to their thickness. To validate the trichoscopic visual scale, we showed the images to 7 dermatologists with interest in hair diseases. Concordance was assessed using the Kendall Tau-b concordance test. A strong correlation between severity of peripilar casts at trichoscopy and degree of lymphocytic infiltrate was observed by the Kendall Tau-b test. Validation showed very good inter- and intraobserver agreement. The trichoscopic visual scale allows noninvasive assessment of scalp inflammation in FFA in different scalp regions and therefore provides optimal guidance for treatment

Short-Spindled Cell Haemangioblastoma with CD34 Expression: New Histopathological Variant or Just a Stochastic Cytological Singularity?

Haemangioblastomas are neoplasms of uncertain histogenesis with cellular and reticular variants advocated in current lore. Herein we describe an intriguing cerebellar specimen with unusual traits including spindle cell morphology and CD34 positivity. A thirty-nine-year old man had an infratentorial tumour discovered incidentally and resected three times. In all the instances, histopathological diagnosis was haemangioblastoma; nonetheless, he had neither physical stigmata nor family history of von Hippel-Lindau disease. By histology, the lesion was composed of areas of conventional stromal cells admixed with territories populated by short-spindled cells packed in lobules, sometimes giving the appearance of gomitoli. Immunoperoxidase-coupled reactions confirmed the expression of inhibin A, neuron-specific enolase (NSE), PS100, and CD57 but also revealed focal immunolabeling for CD34, CD99, and FXIIIa. This case highlights the potential phenotypical diversity that can be found within these neoplasms. Rather than uncertain histogenesis, it may in fact reflect multiple lines of differentiation—histomimesis—prone to adopt unusual morpho- and immunophenotypes in a subset of haemangioblastomas

Historias que hacen historia. Memorias del Simposio sobre la enseñanza de la historia

Este libro es un resultado del diplomado "Enseñanza de la historia en el marco del Bicentenario", desarrollado por el IDEP y la OEI. El libro incluye temas retomados de experiencias vivenciales de las maestras y los maestros en el aula, relacionados con el pensamiento histórico, las teorías de la historia, didáctica de la enseñanza el encuentro de la historia con las ciencias sociales y aspectos académico-curriculares del tema

Programa de desarrollo de conductas de cooperación en el alumnado

Publicada en 2004La investigación se lleva a cabo en cuatro colegios públicos de primaria y participan 14 profesores. Se trata de un programa de intervención basado en juegos amistosos y de cooperación de carácter preventivo y de desarrollo con los siguientes objetivos: potenciar el desarrollo integral de los niños que evolucionan con normalidad, especialmente en su dimensión socio-afectiva y estimular la integración grupal de niños que muestran dificultades en su desarrollo general. La duración fue de nueve meses, la fase de implementación ha coincidido con el curso escolar. Evaluación continua integrada en el propio proceso de aplicación del programa.Comunidad Autónoma de la Región de Murcia. Dirección General de Formación Profesional e Innovación EducativaMurciaConsejería de Educación y Cultura. Secretaría General; Av. de la Fama, 15; 30006 Murcia; Tel. +34968279685; Fax +34968279835; [email protected]

Historias que hacen historia

Resultado del diplomado "Enseñanza de la historia en el marco del bicentenario". Incluye temas retomas de experiencias vivenciales de las maestras y los maestros en el aula, relacionado con el pensamiento histórico, las teorías de la historia, didáctica de la enseñanza, el entrecuzamiento de la historia con las ciencias sociales y aspectos académico-curriculares relacionados con el tema. El lector encontrará en estos escritos un amplio mundo de cuestiones relativas a la historia, que no sólo dan cuenta de épocas pretéritas sino que, desde allí, enlazan con la historia reciente de de Colombia, evidenciando los problemas no resueltos de nuestra construcción como Estado y Nación a lo largo de dos siglos de independencia política. Tiene como valor agregado, académico y disciplinar-histórico, la capacidad de generar en estudiantes y docentes un diálogo-reflexión acerca de la importancia de la historia dentro de las ciencias sociales específicamente, lo cual equivale a examinar la interrelación estructural entre las disciplinas.Presentación El quehacer pedagógico y sus rutas en la enseñanza de la historia.... 9 Primera parte Las rutas pedagógicas y sus antecedentes.... 15 Ruth Amanda Cortés Salcedo, M ireya González, Raúl Barrantes y María Carlota Ortiz Segunda parte Lugares y trayectorias de la enseñanza de la historia.... 29 Ruth Amanda Cortés Salcedo, M ireya González, Raúl Barrantes y María Carlota Ortiz I. Desarrollo del pensamiento ¿Para qué enseñar ciencias sociales? Diversas estrategias didácticas en la enseñanza de la historia y la geografía: una manera de despertar el deseo de conocimiento de forma interdisciplinar.... 47 Flor Ángela Castellanos Enseñar a pensar históricamente: un compromiso del docente de ciencias sociales.... 63 Ángela Velasco Yo soy, yo vengo, yo voy Una propuesta de construcción de pensamiento histórico para estudiantes del ciclo cuarto... 71 Carlos Abril El periódico histórico como herramienta pedagógica en la enseñanza de las ciencias sociales.... 79 Anjie Natalia Pinilla II. Historias de vida y su lugar en la enseñanza El papel liberador del maestro en la sociedad actual..... 87 Ingrid Yisela Calderón Rodríguez Memorias que abren caminos.... 95 Ana Margot Barrantes Clavijo Mi vida: una historia pedagógica .... 103 Martha Consuelo Romero Sánchez Más allá de la condición docente: historias de vida del profesorado 2004.... 111 Humberst Álvarez III. Reflexiones teóricas sobre la enseñanza de la historia y las ciencias sociales De la historia escolar tradicional a la historia de la reconstrucción de la memoria colectiva.... 119 Gloria Bermúdez Las ciencias sociales: ¡Un cambio!... a gritos..... 131 Yised Martínez Cabrera Historia, memoria y subjetividades políticas en la cátedra de Economía y Política..... 139 Margoth Ardila Ariza IV. Didáctica de la historia y las ciencias sociales En torno al entorno: elemento para la enseñanza de las ciencias sociales Construyendo historia de las historias... 147 Nelson Efrén Borda Aprendiendo historia e investigando con las nuevas tecnologías.... 155 Francis Guiomar Córdoba M. Conociendo la historia de Bogotá: una experiencia pedagógica.... 165 Bernardo Amaya Historia, Independencia y América Latina: escenarios para el aprendizaje de las ciencias sociales.... 171 Luz Cristina Rodríguez Pérez V. Memoria e historia reciente en el currículo ¿Memoria o memorias?.... 181 Alejandro Hernández Neira La enseñanza de la historia reciente, un debate pendiente en las ciencias sociales escolares en Colombia. Reflexión sobre la inclusión de la toma y retoma del Palacio de Justicia en el currículo escolar.... 187 Claudia Marcela Castillo Jiménez Investigando con el Bicentenario.... 195 María Angélica Arévalo Salaza