A novel multiobjective evolutionary algorithm based on regression analysis

As is known, the Pareto set of a continuous multiobjective optimization problem with m objective functions is a piecewise continuous (m - 1)-dimensional manifold in the decision space under some mild conditions. However, how to utilize the regularity to design multiobjective optimization algorithms has become the research focus. In this paper, based on this regularity, a model-based multiobjective evolutionary algorithm with regression analysis (MMEA-RA) is put forward to solve continuous multiobjective optimization problems with variable linkages. In the algorithm, the optimization problem is modelled as a promising area in the decision space by a probability distribution, and the centroid of the probability distribution is (m - 1)-dimensional piecewise continuous manifold. The least squares method is used to construct such a model. A selection strategy based on the nondominated sorting is used to choose the individuals to the next generation. The new algorithm is tested and compared with NSGA-II and RM-MEDA. The result shows that MMEA-RA outperforms RM-MEDA and NSGA-II on the test instances with variable linkages. At the same time, MMEA-RA has higher efficiency than the other two algorithms. A few shortcomings of MMEA-RA have also been identified and discussed in this paper

Research on character of screw pile group composite foundation used in high-speed railway

As a result of rapid development of a high-speed railway and infrastructure in China in recent years, the subgrade deformation and settlement control standards put forward more stringent requirements. Based on ABAQUS 6.14, established finite element model of screw pile group composite foundation. Then obtained the settlement, axial force distribution and pile side resistance distribution of center pile of pile group. Next design parameters sensitive analysis was made, such as pile length, pile spacing and so on, in order to obtain a reasonable design pile parameters by analysis of mechanical behavior

Determination of the absorption length of CO2, Nd:YAG and high power diode laser radiation for a selected grouting material

The laser beam absorption lengths of CO2, Nd:YAG and a high power diode laser (HPDL) radiation for a newly developed SiO2/Al2O3-based tile grout have been determined through the application of Beer-Lambert’s law. The findings revealed marked differences in the absorption lengths despite the material having similar beam absorption coefficients for the lasers. The absorption lengths for the SiO2/Al2O3-based tile grout for CO2, Nd:YAG and HPDL radiation were calculated as being 23211 m, 1934 m and 1838 m respectively. Moreover, this method of laser beam absorption length determination, which has hitherto been used predominantly with lasers operated in the pulsed mode, is shown to be valid for use with lasers operated in the continuous wave (CW) mode, depending upon the material being treated

Memetic Differential Evolution with an Improved Contraction Criterion

Memetic algorithms with an appropriate trade-off between the exploration and exploitation can obtain very good results in continuous optimization. In this paper, we present an improved memetic differential evolution algorithm for solving global optimization problems. The proposed approach, called memetic DE (MDE), hybridizes differential evolution (DE) with a local search (LS) operator and periodic reinitialization to balance the exploration and exploitation. A new contraction criterion, which is based on the improved maximum distance in objective space, is proposed to decide when the local search starts. The proposed algorithm is compared with six well-known evolutionary algorithms on twenty-one benchmark functions, and the experimental results are analyzed with two kinds of nonparametric statistical tests. Moreover, sensitivity analyses for parameters in MDE are also made. Experimental results have demonstrated the competitive performance of the proposed method with respect to the six compared algorithms

Multiple Gravity Assist Spacecraft Trajectories Design Based on BFS and EP_DE Algorithm

The paper deals with the multiple gravity assist trajectories design. In order to improve the performance of the heuristic algorithms, such as differential evolution algorithm, in multiple gravity assist trajectories design optimization, a method combining BFS (breadth-first search) and EP DE (differential evolution algorithm based on search space exploring and principal component analysis) is proposed. In this method, firstly find the possible multiple gravity assist planet sequences with pruning based BFS and use standard differential evolution algorithm to judge the possibility of all the possible trajectories. Then select the better ones from all the possible solutions. Finally, use EP DE which will be introduced in this paper to find an optimal decision vector of spacecraft transfer time schedule (launch window and transfer duration) for each selected planet sequence. In this paper, several cases are presented to prove the efficiency of the method proposed

Individual phosphorylation sites at the C-terminus of the apelin receptor play different roles in signal transduction

The apelin and Elabela proteins constitute a spatiotemporal double-ligand system that controls apelin receptor (APJ) signal transduction. Phosphorylation of multiple sites within the C-terminus of APJ is essential for the recruitment of β-arrestins. We sought to determine the precise mechanisms by which apelin and Elabela promote APJ phosphorylation, and to elucidate the influence of β-arrestin phosphorylation on G-protein-coupled receptor (GPCR)/β-arrestin-dependent signaling. We used techniques including mass spectrometry (MS), mutation analysis, and bioluminescence resonance energy transfer (BRET) to evaluate the role of phosphorylation sites in APJ-mediated G-protein-dependent and β-dependent signaling. Phosphorylation of APJ occurred at five serine residues in the C-terminal region (Ser335, Ser339, Ser345, Ser348 and Ser369). We also identified two phosphorylation sites in β-arrestin1 and three in β-arrestin2, including three previously identified residues (Ser412, Ser361, and Thr383) and two new sites, Tyr47 in β-arrestin1 and Tyr48 in β-arrestin2. APJ mutations did not affect the phosphorylation of β-arrestins, but it affects the β-arrestin signaling pathway, specifically Ser335 and Ser339. Mutation of Ser335 decreased the ability of the receptor to interact with β-arrestin1/2 and AP2, indicating that APJ affects the β-arrestin signaling pathway by stimulating Elabela. Mutation of Ser339 abolished the capability of the receptor to interact with GRK2 and β-arrestin1/2 upon stimulation with apelin-36, and disrupted receptor internalization and β-arrestin-dependent ERK1/2 activation. Five peptides act on distinct phosphorylation sites at the APJ C-terminus, differentially regulating APJ signal transduction and causing different biological effects. These findings may facilitate screening for drugs to treat cardiovascular and metabolic diseases

Analysis of clinical indicators in 118 patients with intrauterine adhesions

Objective To explore the differences of different clinical indicators between patients with severe and non-severe intrauterine adhesions （IUA）. Methods Clinical data of 118 patients with IUA diagnosed by hysteroscopy were analyzed retrospectively. According to the AFS scoring standard of IUA, all patients were divided into the severe IUA group （severe group） and mild-moderate IUA group （non-severe group）, and the differences of different clinical indicators between two groups were analyzed. Results Compared with the patients in the non-severe group, the patients in the severe group had more pregnancies, more than two times of uterine curettage, and more times of hysteroscopic resection （all P < 0.05）. There were statistically significant differences between the severe and non-severe groups after induced abortion, hysteroscopic resection, and uterine artery embolization combined with curettage （all P < 0.05）. Among the patients undergoing different times of uterine cavity operations, the difference between the severe and non-severe groups was statistically significant. Compared with the 1-time and 2-time uterine cavity operation groups, the proportion of severe group （85%） in the ≥3-time uterine cavity operation was significantly increased （both P < 0.05）. In the severe group, the proportion of abnormal uterine cavity （heterogenous echoes, continuous interruption, unclear display or adhesion） revealed by transvaginal color Doppler ultrasound was significantly higher than that in the non-severe group （P < 0.05）. Conclusions Induced abortion, hysteroscopic electrosurgery and uterine curettage after uterine artery embolization can increase the risk of IUA. Transvaginal color Doppler ultrasound has good diagnostic value for severe IUA

A method for identifying G protein-coupled receptor dimers and their interfaces

The G protein-coupled receptor (GPCR) dimer interface plays an important role in the formation and stabilization of the dimer. Therefore, identifying the potential receptor-receptor interface is an important part of studying GPCRs. Various strategies have been employed to study the GPCR dimer interface and explore its functional significance, but experimental methods lack robustness and calculations are laborious. Herein, we report a combined optimized experimental and calculation approach for identifying and structurally characterizing GPCR dimer interfaces, and constructing atomic resolution models. Using a transmembrane domain (TM) peptide containing a human immunodeficiency virus trans-acting transcriptional activator (HIV-TAT) protein transduction motif, matrix-assisted laser desorption tandem time-of-flight mass spectrometry (MALDITOF-MS), and bioluminescence resonance energy transfer (BRET), we successfully identified Apelin receptor (APJ)/Nociceptin receptor 1 (ORL1) and APJ/Vasopressin receptor 2 (V2R) heterodimer interfaces, and two key sites mediating dimerization. This method can identify dimer interfaces of GPCR homodimers and heterodimers