Numerical simulation of transient flow in horizontal drainage systems

AbstractA numerical simulation model based on the characteristic-based finite-difference method with a time-line interpolation scheme was developed for predicting transient free surface flow in horizontal drainage systems. The fundamental accuracy of the numerical model was first clarified by comparison with the experimental results for a single drainage pipe. Boundary conditions for junctions and bends, which are often encountered in drainage systems, were studied both experimentally and numerically. The numerical model was applied to an actual drainage system. Comparison with a full-scale model experiment indicates that the model can be used to accurately predict flow characteristics in actual drainage networks

DRAPS: Dynamic and Resource-Aware Placement Scheme for Docker Containers in a Heterogeneous Cluster

Virtualization is a promising technology that has facilitated cloud computing to become the next wave of the Internet revolution. Adopted by data centers, millions of applications that powered by various virtual machines improve the quality of services. Although virtual machines are well-isolated among each other, they suffer from redundant boot volumes and slow provisioning time. To address the limitations, containers were born to deploy and run distributed applications without launching entire virtual machines. As a dominant player, Docker is an open-source implementation of container technology. When managing a cluster of Docker containers, the management tool, Swarmkit, does not take the heterogeneities in both physical nodes and virtualized containers into consideration. The heterogeneity lies in the fact that different nodes in the cluster may have various configurations, concerning resource types and availabilities, etc., and the demands generated by services are varied, such as CPU-intensive (e.g. Clustering services) as well as memory-intensive (e.g. Web services). In this paper, we target on investigating the Docker container cluster and developed, DRAPS, a resource-aware placement scheme to boost the system performance in a heterogeneous cluster

A preliminary study on the key factors contributing to the attractive lips of Chinese children

AbstractObjectiveTo explore the aesthetic characteristics of the Chinese children lips.MethodsFrontal and profile photographs of 653 healthy children were categorized as the attractive and the unattractive by three laypersons and objectively measured for comparison.ResultsThe attractive group tended to be smaller in the upper paramedian red lip height, the lower paramedian red lip height, the midline upper red lip height, the central bow angle, and the lip angle, while greater in the Cupid's bow width.ConclusionsThinner lips seemed to be more attractive than full ones among Chinese children

Back to the Starting Point: on the Simulation of Initial Magnetic Fields and Spin Periods of Non-accretion Pulsars

Neutron stars (NSs) play essential roles in modern astrophysics. Magnetic fields and spin periods of newborn (zero age) NSs have large impact on the further evolution of NSs, which are however poorly explored in observation due to the difficulty of finding newborn NSs. In this work, we aim to infer the magnetic fields and spin periods (Bi and Pi) of zero-age NSs from the observed properties of NS population. We select non-accretion NSs (NANSs) whose evolution is solely determined by magnetic dipole radiation. We find that both Bi and Pi can be described by log-normal distribution and the fitting sensitively depends on our parameters.Comment: 8 pages, 5 figures, accepted for publication in Ap

Intestinal bacteria—a powerful weapon for fungal infections treatment

The morbidity and mortality of invasive fungal infections are rising gradually. In recent years, fungi have quietly evolved stronger defense capabilities and increased resistance to antibiotics, posing huge challenges to maintaining physical health. Therefore, developing new drugs and strategies to combat these invasive fungi is crucial. There are a large number of microorganisms in the intestinal tract of mammals, collectively referred to as intestinal microbiota. At the same time, these native microorganisms co-evolve with their hosts in symbiotic relationship. Recent researches have shown that some probiotics and intestinal symbiotic bacteria can inhibit the invasion and colonization of fungi. In this paper, we review the mechanism of some intestinal bacteria affecting the growth and invasion of fungi by targeting the virulence factors, quorum sensing system, secreting active metabolites or regulating the host anti-fungal immune response, so as to provide new strategies for resisting invasive fungal infection

Label-free quantitative proteomics of CD133-positive liver cancer stem cells

Abstract Background CD133-positive liver cancer stem cells, which are characterized by their resistance to conventional chemotherapy and their tumor initiation ability at limited dilutions, have been recognized as a critical target in liver cancer therapeutics. In the current work, we developed a label-free quantitative method to investigate the proteome of CD133-positive liver cancer stem cells for the purpose of identifying unique biomarkers that can be utilized for targeting liver cancer stem cells. Label-free quantitation was performed in combination with ID-based Elution time Alignment by Linear regression Quantitation (IDEAL-Q) and MaxQuant. Results Initially, IDEAL-Q analysis revealed that 151 proteins were differentially expressed in the CD133-positive hepatoma cells when compared with CD133-negative cells. We then analyzed these 151 differentially expressed proteins by MaxQuant software and identified 10 significantly up-regulated proteins. The results were further validated by RT-PCR, western blot, flow cytometry or immunofluorescent staining which revealed that prominin-1, annexin A1, annexin A3, transgelin, creatine kinase B, vimentin, and EpCAM were indeed highly expressed in the CD133-positive hepatoma cells. Conclusions These findings confirmed that mass spectrometry-based label-free quantitative proteomics can be used to gain insights into liver cancer stem cells.http://deepblue.lib.umich.edu/bitstream/2027.42/113089/1/12953_2012_Article_407.pd

Soil Abiotic Properties and Plant Functional Traits Mediate Associations Between Soil Microbial and Plant Communities During a Secondary Forest Succession on the Loess Plateau

In the context of secondary forest succession, aboveground-belowground interactions are known to affect the dynamics and functional structure of plant communities. However, the links between soil microbial communities, soil abiotic properties, plant functional traits in the case of semi-arid and arid ecosystems, are unclear. In this study, we investigated the changes in soil microbial species diversity and community composition, and the corresponding effects of soil abiotic properties and plant functional traits, during a ≥150-year secondary forest succession on the Loess Plateau, which represents a typical semi-arid ecosystem in China. Plant community fragments were assigned to six successional stages: 1–4, 4–8, 8–15, 15–50, 50–100, and 100–150 years after abandonment. Bacterial and fungal communities were analyzed by high-throughput sequencing of the V4 hypervariable region of the 16S rRNA gene and the internal transcribed spacer (ITS2) region of the rRNA operon, respectively. A multivariate variation-partitioning approach was used to estimate the contributions of soil properties and plant traits to the observed microbial community composition. We found considerable differences in bacterial and fungal community compositions between the early (S1–S3) and later (S4–S6) successional stages. In total, 18 and 12 unique families were, respectively, obtained for bacteria and fungi, as indicators of microbial community succession across the six stages. Bacterial alpha diversity was positively correlated with plant species alpha diversity, while fungal diversity was negatively correlated with plant species diversity. Certain fungal and bacterial taxa appeared to be associated with the occurrence of dominant plant species at different successional stages. Soil properties (pH, total N, total C, NH4-N, NO3-N, and PO4-P concentrations) and plant traits explained 63.80% and 56.68% of total variance in bacterial and fungal community compositions, respectively. These results indicate that soil microbial communities are coupled with plant communities via the mediation of microbial species diversity and community composition over a long-term secondary forest succession in the semi-arid ecosystem. The bacterial and fungal communities show distinct patterns in response to plant community succession, according to both soil abiotic properties and plant functional traits

Factors associated with euphoria in a large subset of cases using propofol sedation during gastrointestinal endoscopy

BackgroundThe utilization of Propofol, a widely used intravenous sedative or anesthetic, is characterized by its quick onset, predictable control, and fleeting half-life during both general anesthesia and intensive care unit sedation. Recent evidence, however, has highlighted propofol’s propensity to induce euphoria, particularly in patients undergoing painless procedures such as gastrointestinal or gastric endoscopy. Given its widespread use in patients undergoing such procedures, this study aims to investigate the clinical evidence and factors that may influence propofol-induced euphoria in these settings.MethodsThe Addiction Research Center Inventory-Chinese Version (ARCI-CV) scale was administered to 360 patients undergoing gastric or gastrointestinal endoscopy using propofol as a sedative. Patient characteristics including past medical history, depression, anxiety, alcohol abuse, and sleep disturbance were recorded through history taking and assessment using various questionnaires prior to the examination. The euphoric and sedative statuses were assessed at 30 min and 1 week post-examination.ResultsThe experimental results of a survey of 360 patients who underwent gastric or gastrointestinal endoscopy using propofol showed that the mean Morphine–Benzedrine Group (MBG) score before the procedure and after 30 min of the procedure was 4.23 and 8.67, respectively. The mean Pentobarbital–Chlorpromazine–Alcohol Group (PCAG) score before the procedure and after 30 min of the procedure was 3.24 and 6.22, respectively. These results showed that both MBG and PCAG scores increased significantly after the procedure. Certain factors, such as dreaming, propofol dose, duration of anesthesia, and etomidate dose, were all correlated with MBG both at 30 min and 1 week after the examination. In addition, etomidate had an effect of decreasing MBG scores and increasing PCAG scores both at 30 min and 1 week after the examination.ConclusionTaken together, propofol may elicit euphoria and potentially contribute to propofol addiction. There are several risk factors for the development of propofol addiction, including dreaming, propofol dose, duration of anesthesia, and etomidate dose. These findings suggest that propofol may have a euphoric effect and may have the potential for drug addiction and abuse