Chlorido{μ-2,6-bis­[(2-amino­eth­yl)imino­meth­yl]-4-chloro­phenolato}-μ-oxido-dicopper(II) trihydrate

In the title dinuclear complex, [Cu2(C14H20ClN4O)ClO]·3H2O, one CuII cation assumes a distorted square-planar coordination geometry and the other a distorted square-pyramidal coordination geometry. Both CuII cations are N,N′,O-chelated by one arm of the 2,6-bis­[(2-amino­eth­yl)imino­meth­yl]-4-chloro­phenolate anion, and one oxide anion bridges the two CuII cations, forming a dinuclear complex. One of the CuII cations is further coordinated by an Cl− anion in the apical direction. In the crystal, lattice water mol­ecules are linked with the complex mol­ecule via O—H⋯Cl hydrogen bonds while O—H⋯O hydrogen bonding occurs between lattice water mol­ecules , forming three-dimensional network structure

[2-({Benz­yl[2-(benz­yl{5-methyl-2-oxido-3-[(pyridin-2-ylmeth­yl)imino­meth­yl]benz­yl}amino)­eth­yl]aza­nium­yl}meth­yl)-4-methyl-6-[(pyridin-2-ylmeth­yl)imino­meth­yl]phenolato]nickel(II) perchlorate methanol disolvate

In the solvated title complex, [Ni(C46H47N6O2)]ClO4·2CH4O, the coordination sphere around the NiII ion can be described as distorted cis-NiO2N4 octa­hedral defined by two phenolate O atoms and four N atoms from the hexa­dentate ligand. An intra­molecular bifurcated N—H⋯(N,O) hydrogen bond helps to establish the conformation of the complex mol­ecule. In the crystal, the components are connected by O—H⋯O and C—H⋯O hydrogen bonds

[2-Formyl-4-methyl-6-({2-[2-(4-nitro­benzyl­amino)­ethyl­amino]­ethyl­imino}­meth­yl)phenolato]nickel(II) perchlorate

In the unsymmetrical title complex, [Ni(C20H23N4O4)]ClO4, the coordination geometry for the NiII atom can be described as square planar. The aromatic rings in the two ligands are almost vertical, with a dihedral angle of 85.3°. In the crystal, cations and anions are linked by weak C(N)—H⋯O hydrogen bonding

Cochlear homeostasis and its role in genetic deafness

AbstractEach component of the human ear performs a specific function in hearing. The actual process of sound transduction takes place in the auditory portion of the inner ear, the fluid-filled cochlea. In the cochlea, the sensitivity and efficiency of sensory apparatus to convert mechanical energy into neural activity, largely depends on the fluidic and ionic environment. In the lateral wall of cochlea, the secretory epithelium stria vascularis plays an important role in the maintenance of fluidic and ionic homeostasis. A variety of gene mutations disturbs the cochlear homeostasis and subsequently leads to hearing impairment. The review covers several aspects of cochlear homeostasis, from cochlear fluid and the functional role of stria vascularis, cochlear K+recycling and its molecular substrates to genetic deafness with abnormal cochlear homeostasis

AEG-1 participates in high glucose-induced activation of Rho kinase and epithelial–mesenchymal transition in proximal tubular epithelial cells

AbstractObjectiveTo prove whether astrocyte elevated gene-1 (AEG-1) plays a role in high glucose-stimulated Rho kinase activation and epithelial–mesenchymal transition (EMT) in human renal tubular epithelial (HK-2) cells.MethodsThe protein levels of AEG-1, alpha-smooth muscle actin, E-cadherin and MYPT1 were determined by Western blot.ResultsAEG-1 protein level was upregulated in HK-2 cells stimulated with high glucose. AEG-1 siRNA downregulated Rho kinase protein expression and blocked high glucose-induced EMT.ConclusionsOur results show that AEG-1 acts a key role in high glucose-induced activation of Rho kinase and EMT in HK-2 cells

Study on Law of Personnel Evacuation in Deep Buried Metro Station Based on the Characteristics of Fire Smoke Spreading

AbstractWith the improvement of people's life and the rapid development of urban traffic, the subway has the advantages of convenience and celerity, to a large extent, which greatly eases the traffic congestion phenomenon. With the attendant, the safety of the subway environment becomes vital. Many engineers focus on the study of the fire prevention and safety to escape. In this paper, a comprehensive study on the fire smoke spreading and the evacuation of the people in the deep buried metro model is carried out. First, the deep buried metro model is modeled on the STEPS software, and the personnel evacuation rule is obtained. According to the evacuation situation, the corresponding fire smoke monitoring points are built in the fire scenario which is set up on FDS+Evac software. Then, FDS+Evac program is used to simulate the evacuation in a fire scenario. It has not only analyzed the real time effect that the characteristics of fire smoke spread have on the personnel evacuation, but also improved the accuracy of the subway fire safety evaluation