A comparison of the performance of the ice and ocean tracking modes of the ERS‐1 radar altimeter over non‐ocean surfaces

The European Space Agency's ERS-1 radar altimeter is the first to include separate operating modes to optimise performance over both ocean and non-ocean surfaces. As part of the ERS-1 commissioning activities, we have carried out a study of the tracking performance of this instrument over non-ocean surfaces. Statistics for land ice, sea ice, arid lands, and inland water are presented. Performance in both operating modes is shown to be better than that of previous missions

mCCDcl1 cells show Plasticity Consistent with the Ability to Transition between Principal and Intercalated Cells

The cortical collecting duct of the mammalian kidney plays a critical role in the regulation of body volume, sodium pH, and osmolarity and is composed of two distinct cells types, principal cells and intercalated cells. Each cell type is detectable in the kidney by the localization of specific transport proteins such as aquaporin 2 (Aqp2) and epithelial sodium channel (ENaC) in principal cells and V-ATPase B1 and connexin 30 (Cx30) in intercalated cells. mCCD cl1 cells have been widely used as a mouse principal cell line on the basis of their physiological characteristics. In this study, the mCCD cl1 parental cell line and three sublines cloned from isolated single cells (Ed1, Ed2, and Ed3) were grown on filters to assess their transepithelial resistance, transepithelial voltage, equivalent short circuit current and expression of the cell-specific markers Aqp2, ENaC, V-ATPaseB1, and Cx30. The parental mCCD cl1 cell line presented amiloride-sensitive electrogenic sodium transport indicative of principal cell function; however, immunocytochemistry and RT-PCR showed that some cells expressed the intercalated cell-specific markers V-ATPase B1 and Cx30, including a subset of cells also positive for Aqp2 and ENaC. The three subclonal lines contained cells that were positive for both intercalated and principal cell-specific markers. The vertical transmission of both principal and intercalated cell characteristics via single cell cloning reveals the plasticity of mCCD cl1 cells and a direct lineage relationship between these two physiologically important cell types and is consistent with mCCDcl1 cells being precursor cells. </p

The lack of theoretical support for using person trade-offs in QALY-type models

Person trade-off, QALY, DALY, Pareto principle, Social welfare, H4, I1, D6,