The Adams Federalists

Originally published in 1953. Between 1789 and 1803, the United States existed as a developing national state, sparsely settled. The de facto precedents of America's nascent political system had not yet been fleshed out by the generation of statesmen who paved its political way. Historians have examined the rise of the party system in US politics by emphasizing the Jeffersonians, who—led by Thomas Jefferson—helped to develop an agrarian voting bloc. In The Adams Federalists, Manning J. Dauer attends to Adams's struggles with the Federalist Party, arguing that his term is the key to understanding the success of the Jeffersonians in promoting their own democratic ideals. Dauer attributes the fall of Federalism to Adams's failure to maintain a moderate cohort in the White House. The Federalist Party's leadership increasingly adopted policies that isolated the Federalists' agrarian supporters, who in turn found support in the Jeffersonians' archaic politics. Professor Dauer provides an alternative explanation for the popularity of Jefferson's political faction and argues that economic factors undergirded the political organization of early America's voting base. Since its publication, scholars have recognized The Adams Federalists as a definitive study of the Federalist Party during the Adams administration

International collaborative study for the calibration of proposed International Standards for thromboplastin, rabbit, plain, and for thromboplastin, recombinant, human, plain

To access publisher's full text version of this article click on the hyperlink belowEssentials Two candidate International Standards for thromboplastin (coded RBT/16 and rTF/16) are proposed. International Sensitivity Index (ISI) of proposed standards was assessed in a 20-centre study. The mean ISI for RBT/16 was 1.21 with a between-centre coefficient of variation of 4.6%. The mean ISI for rTF/16 was 1.11 with a between-centre coefficient of variation of 5.7%. SUMMARY: Background The availability of International Standards for thromboplastin is essential for the calibration of routine reagents and hence the calculation of the International Normalized Ratio (INR). Stocks of the current Fourth International Standards are running low. Candidate replacement materials have been prepared. This article describes the calibration of the proposed Fifth International Standards for thromboplastin, rabbit, plain (coded RBT/16) and for thromboplastin, recombinant, human, plain (coded rTF/16). Methods An international collaborative study was carried out for the assignment of International Sensitivity Indexes (ISIs) to the candidate materials, according to the World Health Organization (WHO) guidelines for thromboplastins and plasma used to control oral anticoagulant therapy with vitamin K antagonists. Results Results were obtained from 20 laboratories. In several cases, deviations from the ISI calibration model were observed, but the average INR deviation attributabled to the model was not greater than 10%. Only valid ISI assessments were used to calculate the mean ISI for each candidate. The mean ISI for RBT/16 was 1.21 (between-laboratory coefficient of variation [CV]: 4.6%), and the mean ISI for rTF/16 was 1.11 (between-laboratory CV: 5.7%). Conclusions The between-laboratory variation of the ISI for candidate material RBT/16 was similar to that of the Fourth International Standard (RBT/05), and the between-laboratory variation of the ISI for candidate material rTF/16 was slightly higher than that of the Fourth International Standard (rTF/09). The candidate materials have been accepted by WHO as the Fifth International Standards for thromboplastin, rabbit plain, and thromboplastin, recombinant, human, plain.Stichting Kwaliteitsbewaking Medische Laboratoriumdiagnostiek (Nijmegen, the Netherlands