Galaxy gas ejection in radio galaxies: the case of 3C 35

We report results from XMM-Newton and Chandra observations of the nearby (z = 0.067) giant radio galaxy 3C 35. We find evidence for an X-ray emitting gas belt, orthogonal to and lying between the lobes of 3C 35, which we interpret as fossil-group gas driven outwards by the expanding radio lobes. We also detect weak emission from a second, more extended group-type environment, as well as inverse-Compton X-ray emission from the radio lobes. The morphological structure of the radio lobes and gas belt point to co-evolution. Furthermore, the radio source is powerful enough to eject galaxy-scale gas out to distances of 100kpc, and the ages of the two features are comparable (tsynch~140Myr, tbelt~80 Myr). The destruction of 3C 35's atmosphere may offer clues as to how fossil systems are regulated: radio galaxies need to be of power comparable to 3C 35 to displace and regulate fossil-group gas. We discuss the implications of the gas belt in 3C 35 in terms of AGN fuelling and feedback.Comment: 18 pages, accepted to MNRA

A BIOMECHANICAL ANALYSIS OF THE INSTEP KICK IN SOCCER WITH PREFERRED AND NON-PREFERRED FOOT

This study examined the kinematics of preferred and non-preferred instep kicking action in competitive soccer players. Using two gen-locked cameras, SHVS video data were obtained for seven players completing eight maximal effort instep kicks at a target with both feet. 3D kinematic analysis was carried out using Peak Motus to obtain joint angles of the standing and kicking legs and the frontal plane pelvic tilt angle. The results showed that when kicking with the preferred limb, the players’ standing foot was closer to the ball and they used a larger frontal plane pelvic tilt angle and greater knee extension of the kicking leg at ball impact. There was greater variability in the kicking leg knee angle and this is consistent with Dynamical Systems Theory

Identifying clustering at high redshift through actively star-forming galaxies

Identifying galaxy clustering at high redshift (i.e. z > 1) is essential to our understanding of the current cosmological model. However, at increasing redshift, clusters evolve considerably in star-formation activity and so are less likely to be identified using the widely-used red sequence method. Here we assess the viability of instead identifying high redshift clustering using actively star-forming galaxies (SMGs associated with over-densities of BzKs/LBGs). We perform both a 2- and 3-D clustering analysis to determine whether or not true (3D) clustering can be identified where only 2D data are available. As expected, we find that 2D clustering signals are weak at best and inferred results are method dependant. In our 3D analysis, we identify 12 SMGs associated with an over-density of galaxies coincident both spatially and in redshift - just 8% of SMGs with known redshifts in our sample. Where an SMG in our target fields lacks a known redshift, their sightline is no more likely to display clustering than blank sky fields; prior redshift information for the SMG is required to identify a true clustering signal. We find that the strength of clustering in the volume around typical SMGs, while identifiable, is not exceptional. However, we identify a small number of highly clustered regions, all associated with an SMG. The most notable of these, surrounding LESSJ033336.8-274401, potentially contains an SMG, a QSO and 36 star-forming galaxies (a > 20sig over-density) all at z~1.8. This region is highly likely to represent an actively star-forming cluster and illustrates the success of using star-forming galaxies to select sites of early clustering. Given the increasing number of deep fields with large volumes of spectroscopy, or high quality and reliable photometric redshifts, this opens a new avenue for cluster identification in the young Universe.Comment: 24 pages, 14 figures, accepted MNRA

Immunity to self co-generates regulatory T cells

Immune responses to self are kept in check by tolerance mechanisms, including suppression by regulatory T cells (Tregs). The defective generation of Tregs specific for self-antigens may lead to autoimmune disease. We identified a novel population of human CD4^+^ Tregs, characterized by high surface expression of CD52, which is co-generated in response to autoantigen. Blood CD4^+^CD52^hi^ T cells were generated preferentially in response to low-dose autoantigen and suppressed proliferation and interferon-[gamma] production by other T cells. Depletion of resting CD4^+^CD52^hi^ T cells enhanced the T-cell response to autoantigen. CD4^+^CD52^hi^ Tregs were neither derived from nor distinguished by markers of conventional resting CD4^+^CD25^+^ Tregs. In response to the pancreatic islet autoantigens glutamic acid decarboxylase, the generation of CD4^+^CD52^hi^ Tregs was impaired in individuals with and at-risk for type 1 diabetes, compared to healthy controls and individuals with type 2 diabetes. CD4^+^CD52^hi^ Tregs co-generated to self-antigen may therefore contribute to immune homeostasis and protect against autoimmune disease

SEX-DEPENDENT DIFFERENCES IN DRUG METABOLISM IN THE RAT III. Temporal Changes in Type I Binding and NADPH-Cytochrome, P-450 Reductase during Sexual Maturation

ABSTRACT Microsomal ethylmorphine N-demethylase activity increased with age in male rats, but decreased with age in female rats. Relative to the cytochrome P-450 content of microsomes