Dynamics of solar wind protons reflected by the Moon

Solar system bodies that lack a significant atmosphere and significant internal magnetic fields, such as the Moon and asteroids, have been considered as passive absorbers of the solar wind. However, ion observations near the Moon by the SELENE spacecraft show that a fraction of the impacting solar wind protons are reflected by the surface of the Moon. Using new observations of the velocity spectrum of these reflected protons by the SARA experiment on-board the Chandrayaan-1 spacecraft at the Moon, we show by modeling that the reflection of solar wind protons will affect the global plasma environment. These global perturbations of the ion fluxes and the magnetic fields will depend on microscopic properties of the object's reflecting surface. This solar wind reflection process could explain past ion observations at the Moon, and the process should occur universally at all atmosphereless non-magnetized objects.Comment: 12 pages, 8 figure

Challenging epistemologies of objectivity through collaborative pedagogy: Centering identity, power, emotions, and place in teacher education

In this essay, we discuss how we have attempted to counter the ongoing dominance and (re)inscription of White supremacist, ableist, and settler colonial ways of knowing and being within an elementary teacher education program (TEP) through a consideration of identity and power, emotions and place-based pedagogy. Our approaches indicate means for regenerating and expanding upon marginalized epistemologies in TEPs, challenging curricular epistemicide, while our stories also indicate that these approaches and related ways of knowing are intertwined with our own identities, histories and felt experiences as well as challenges to our enactment of this work

The influence of strength of hyperon-hyperon interactions on neutron star properties

An equation of state of neutron star matter with strange baryons has been obtained. The effects of the strength of hyperon-hyperon interactions on the equations of state constructed for the chosen parameter sets have been analyzed. Numerous neutron star models show that the appearance of hyperons is connected with the increasing density in neutron star interiors. The performed calculations have indicated that the change of the hyperon-hyperon coupling constants affects the chemical composition of a neutron star. The obtained numerical hyperon star models exclude large population of strange baryons in the star interior.Comment: 18 pages, 22 figures, accepted to be published in Journal of Physics G: Nuclear and Particle Physic

Cholinergic and dopaminergic effects on prediction error and uncertainty responses during sensory associative learning

Navigating the physical world requires learning probabilistic associations between sensory events and their change in time (volatility). Bayesian accounts of this learning process rest on hierarchical prediction errors (PEs) that are weighted by estimates of uncertainty (or its inverse, precision). In a previous fMRI study we found that low-level precision-weighted PEs about visual outcomes (that update beliefs about associations) activated the putative dopaminergic midbrain; by contrast, precision-weighted PEs about cue-outcome associations (that update beliefs about volatility) activated the cholinergic basal forebrain. These findings suggested selective dopaminergic and cholinergic influences on precision-weighted PEs at different hierarchical levels. Here, we tested this hypothesis, repeating our fMRI study under pharmacological manipulations in healthy participants. Specifically, we performed two pharmacological fMRI studies with a between-subject double-blind placebo-controlled design: study 1 used antagonists of dopaminergic (amisulpride) and muscarinic (biperiden) receptors, study 2 used enhancing drugs of dopaminergic (levodopa) and cholinergic (galantamine) modulation. Pooled across all pharmacological conditions of study 1 and study 2, respectively, we found that low-level precision-weighted PEs activated the midbrain and high-level precision-weighted PEs the basal forebrain as in our previous study. However, we found pharmacological effects on brain activity associated with these computational quantities only when splitting the precision-weighted PEs into their PE and precision components: in a brainstem region putatively containing cholinergic (pedunculopontine and laterodorsal tegmental) nuclei, biperiden (compared to placebo) enhanced low-level PE responses and attenuated high-level PE activity, while amisulpride reduced high-level PE responses. Additionally, in the putative dopaminergic midbrain, galantamine compared to placebo enhanced low-level PE responses (in a body-weight dependent manner) and amisulpride enhanced high-level precision activity. Task behaviour was not affected by any of the drugs. These results do not support our hypothesis of a clear-cut dichotomy between different hierarchical inference levels and neurotransmitter systems, but suggest a more complex interaction between these neuromodulatory systems and hierarchical Bayesian quantities. However, our present results may have been affected by confounds inherent to pharmacological fMRI. We discuss these confounds and outline improved experimental tests for the future

A microtubule RELION-based pipeline for cryo-EM image processing

Microtubules are polar filaments built from αβ-tubulin heterodimers that exhibit a range of architectures in vitro and in vivo. Tubulin heterodimers are arranged helically in the microtubule wall but many physiologically relevant architectures exhibit a break in helical symmetry known as the seam. Noisy 2D cryo-electron microscopy projection images of pseudo-helical microtubules therefore depict distinct but highly similar views owing to the high structural similarity of α- and β-tubulin. The determination of the αβ-tubulin register and seam location during image processing is essential for alignment accuracy that enables determination of biologically relevant structures. Here we present a pipeline designed for image processing and high-resolution reconstruction of cryo-electron microscopy microtubule datasets, based in the popular and user-friendly RELION image-processing package, Microtubule RELION-based Pipeline (MiRP). The pipeline uses a combination of supervised classification and prior knowledge about geometric lattice constraints in microtubules to accurately determine microtubule architecture and seam location. The presented method is fast and semi-automated, producing near-atomic resolution reconstructions with test datasets that contain a range of microtubule architectures and binding proteins

The extended, relativistic hyperon star model

In this paper an equation of state of neutron star matter which includes strange baryons in the framework of Zimanyi and Moszkowski (ZM) model has been obtained. We concentrate on the effects of the isospin dependence of the equation of state constructing for the appropriate choices of parameters the hyperons star model. Numerous neutron star models show that the appearance of hyperons is connected with the increasing density in neutron star interiors. Various studies have indicated that the inclusion of delta meson mainly affects the symmetry energy and through this the chemical composition of a neutron star. As the effective nucleon mass contributes to hadron chemical potentials it alters the chemical composition of the star. In the result the obtained model of the star not only excludes large population of hadrons but also does not reduce significantly lepton contents in the star interior.Comment: 22 pages, revtex4, 13 figure

MANET Hidden and Exposed Terminal - Challenges and Survey

Mobile Adhoc Network (MANET)is a self organized wireless Network which was created to communicate among  the nodes without support of the any Infrastructure. While transmission of the packets between the nodes, many challenges the every nodes faces. One of the Major challenges is Hidden and Exposed nodes issues in the MANET. This causes the packet drop or packet failure while the transmitting the packets. Also which  reflects in degrades the throughput of the MANET and performance of the MANET nodes when the heavy traffic ,retransmission of the dropped packets delayed the communication. This article discussed about hidden and Exposed terminal problem and challenges in MANET and also dissimilar survey in MANET

The nucleon and mesons effective masses in the Relativistic Mean-Field Theory

Nucleon and meson effective masses in the nonlinear Relativistic Mean - Field Theory (RMF) introducing a nonlinear omega - rho and sigma coupling motivated by the Quark Meson Coupling model (QMC) is explored. It is shown that, in contrast to the usual Walecka model, not only the effective nucleon mass m_{eff,N} but also the effective sigma, rho meson masses (m_{eff, sigma}, m_{eff, rho}) and the effective omega meson mass m_{eff, omega} are nucleon density dependent.Comment: 11 pages, iop latex2e, 7 colour figures, revised version of nucl-th/0011084, accepted to Journal of Physics G: Nuclear and Particle, presented on "Mesons & Light Nuclei '01", Prague, June 200

A lipid-based delivery platform for thermo-responsive delivery of teriparatide

Teriparatide (and analogue peptides) are the only FDA approved anabolic treatments for osteoporosis. Current therapies are administered as a daily subcutaneous injection, which limits patient adherence and clinical efficacy. To achieve the desired anabolic effect, a controlled delivery system must ensure a pulsatile release profile over a prolonged period. Thermo-responsive formulations (e.g. liposomes) can undergo a temperature-related phase-transition which can allow active control of drug release. Herein, thermo-responsive liposomes were developed to permit precise control over the teriparatide release rate through modulation of temperature. Entrapment of hydrophilic molecules, including peptides within liposomes remains challenging due to the large volume of hydration. In this work, hydrophobic ion pairing was employed for the first time to enhance peptide entrapment within liposomes. The method resulted in a hydrophobic complex that achieved high teriparatide entrapment (>75 %) in sub-200 nm, monodispersed liposomes. Hydrophobic ion pairing outperformed other entrapment approaches. Several liposomal formulations with transition temperatures between 38 – 50 °C were obtained by modulation of the phospholipid composition. In vitro release assays demonstrated temperature-dependent release kinetics with faster rates of release observed at/above the transition temperature. The maintenance of biological activity of released teriparatide was demonstrated in a cell-based assay utilising the PTH1 receptor. Overall, this provides the first proof-of-concept of the suitability of thermo-responsive systems for pulsatile delivery of teriparatide and similar peptides

Односторонний и двусторонний эффект памяти формы в [([3)12]]-монокристаллах сплава Ni[49]Fe[18]Ga[27]Co[6]

This study was performed to assess the role of additional myocardial perfusion imaging during high dose dobutamine/atropine stress magnetic resonance (DSMR-wall motion) for the evaluation of patients with intermediate (50-70%) coronary artery stenosis. Routine DSMR-wall motion was combined with perfusion imaging (DSMR-perfusion) in 174 consecutive patients with chest pain syndromes who were scheduled for a clinically indicated coronary angiography. When defining CAD as the presence of a ≥ 50% stenosis, the addition of perfusion imaging improved sensitivity (90 vs. 79%, P < 0.001) with a non-significant reduction in specificity (85 vs. 90%, P = 0.13) and an improvement in overall diagnostic accuracy (88 vs. 84%, P = 0.008). Adding perfusion imaging improved sensitivity in patients with intermediate stenosis (87 vs. 72%, P = 0.03), but not in patients with severe (≥70%) stenosis (93 vs. 84%, P = 0.06). In patients with severe stenosis specificity of DSMR-perfusion versus DSMR-wall motion decreased (61 vs 70%, P = 0.001) resulting in a lower overall accuracy (71 vs 74%, P = 0.03). Using a cutoff of ≥50% for the definition of CAD, sensitivity of DSMR-perfusion compared to DSMR-wall motion was significantly higher in patients with single vessel (88 vs. 77%, P = 0.03) and multi vessel disease (93 vs. 79%, P = 0.03), whereas no significant differences were found using a cutoff of ≥70% stenosis for the definition of CAD. The addition of perfusion imaging during DSMR-wall motion improved the sensitivity in patients with intermediate coronary artery stenosis. Overall diagnostic accuracy increased only when defining CAD as ≥50% stenosis. In patients with ≥70% stenosis DSMR-wall motion alone had higher accuracy due to more false-positive cases with DSMR-perfusion