Modeling Kinetic Glomerular Filtration Rate in Adults with Stable and Unstable Kidney Function: Vancomycin as the Motivating Example

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/162720/2/phar2442_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162720/1/phar2442.pd

Reappraisal of Contemporary Pharmacokinetic and Pharmacodynamic Principles for Informing Aminoglycoside Dosing

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147085/1/phar2193.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147085/2/phar2193_am.pd

Comparison of Body Size, Morphomics, and Kidney Function as Covariates of High‐Dose Methotrexate Clearance in Obese Adults with Primary Central Nervous System Lymphoma

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154919/1/phar2379.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154919/2/phar2379_am.pd

Using l‐Carnitine as a Pharmacologic Probe of the Interpatient and Metabolic Variability of Sepsis

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/162752/2/phar2448_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/162752/1/phar2448.pd

Executive Summary: Therapeutic Monitoring of Vancomycin for Serious Methicillin- Resistant Staphylococcus aureus Infections: A Revised Consensus Guideline and Review of the American Society of Health- System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154898/1/phar2376.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154898/2/phar2376_am.pd

Antimicrobial Dosing in Specific Populations and Novel Clinical Methodologies: Kidney Function

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/167051/1/cpt2179_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/167051/2/cpt2179.pd

Antimicrobial Dosing in Specific Populations and Novel Clinical Methodologies: Obesity

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/167113/1/cpt2181.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/167113/2/cpt2181_am.pd

Translation of Pharmacodynamic Biomarkers of Antibiotic Efficacy in Specific Populations to Optimize Doses

Antibiotic efficacy determination in clinical trials often relies on non-inferiority designs because they afford smaller study sample sizes. These efficacy studies tend to exclude patients within specific populations or include too few patients to discern potential differences in their clinical outcomes. As a result, dosing guidance in patients with abnormal liver and kidney function, age across the lifespan, and other specific populations relies on drug exposure-matching. The underlying assumption for exposure-matching is that the disease course and the response to the antibiotic are similar in patients with and without the specific condition. While this may not be the case, clinical efficacy studies are underpowered to ensure this is true. The current paper provides an integrative review of the current approach to dose selection in specific populations. We review existing clinical trial endpoints that could be measured on a more continuous rather than a discrete scale to better inform exposure–response relationships. The inclusion of newer systemic biomarkers of efficacy can help overcome the current limitations. We use a modeling and simulation exercise to illustrate how an efficacy biomarker can inform dose selection better. Studies that inform response-matching rather than exposure-matching only are needed to improve dose selection in specific populations

Antifungal Combinations against Simulated Candida albicans Endocardial Vegetations▿

The in vitro effects of flucytosine (5FC), liposomal amphotericin B (L-AmB), and micafungin (Mica) combinations against two Candida albicans strains that simulated 24-hour-old endocardial vegetations were studied. Mica was superior to 5FC or L-AmB, and the 5FC-L-AmB-Mica combination was superior to all other treatments for one strain but no different from the dual combination of L-AmB-Mica for the other strain