Time Independent Signature Verification using Normalized Weighted Coefficients

Signature verification is one of the most widely accepted verification methods in use. The application of handwritten signatures includes the banker’s checks, the credit and debit cards issued by banks and various legal documents. The time factor plays an important role in the framing of signature of an individual person. Signatures can be classified as: offline signature verification and online signature verification. In this paper a time independent signature verification using normalized weighted coefficients is presented. If the signature defining parameters are updated regularly according to the weighted coefficients, then the performance of the system can be increased to a significant level. Results show that by taking normalized weighted coefficients the performance parameters, FAR and FRR, can be improved significantly

Signature Verification using Normalized Static Features and Neural Network Classification

Signature verification is very widely used in verification of the identity of any person. Now a days other biometric verification system has been evolved very widely like figure print, iris etc., but signature verification through computer system is still in development phase. The verification system is either through offline mode or online mode in online systems the dynamic information of a signature captured at the time the signature is made while in offline systems based on the scanned image of a signature. In this paper, a method is presented for Offline signatures Verification, for this verification system signature image is first pre-processed and converted into binary image of same size with 200x200 Pixels and then different features are extracted from the image like Eccentricity, Kurtosis, Skewness etc. and that features are used to train the neural network using back-propagation technique. For this verification system 6 different user signatures are taken to make database of the feature and results are analysed. The result demonstrate the efficiency of the proposed methodology when compared with other existing studies. The proposed algorithm gives False Acceptance Rate (FAR) as 5.05% and False Rejection rate (FRR) as 4.25%

COMPARISON OF DENOISING FILTERS ON COLOUR TEM IMAGE FOR DIFFERENT NOISE

TEM (Transmission Electron Microscopy) is an important morphological characterization tool for Nanomaterials. Quite often a microscopy image gets corrupted by noise, which may arise in the process of acquiring the image, or during its transmission, or even during reproduction of the image. Removal of noise from an image is one of the most important tasks in image processing. Denoising techniques aim at reducing the statistical perturbations and recovering as well as possible the true underlying signal. Depending on the nature of the noise, such as additive or multiplicative type of noise, there are several approaches towards removing noise from an image. Image De-noising improves the quality of images acquired by optical, electro-optical or electronic microscopy. This paper compares five filters on the measures of mean of image, signal to noise ratio, peak signal to noise ratio & mean square error. In this paper four types of noise (Gaussian noise, Salt & Pepper noise, Speckle noise and Poisson noise) is used and image de-noising performed for different noise by various filters (WFDWT, BF, HMDF, FDE, DVROFT). Further results have been compared for all noises. It is observed that for Gaussian Noise WFDWT & for other noises HMDF has shown the better performance results

Analysis of intracellular expressed proteins of Mycobacterium tuberculosis clinical isolates

<p>Abstract</p> <p>Background</p> <p>Tuberculosis (TB) is the most threatening infectious disease globally. Although progress has been made to reduce global incidence of TB, emergence of multidrug resistant (MDR) TB threatens to undermine these advances. To combat the disease, novel intervention strategies effective against drug resistant and sensitive subpopulations of <it>M. tuberculosis </it>are urgently required as adducts in the present treatment regimen. Using THP-1 cells we have analyzed and compared the global protein expression profile of broth-cultured and intraphagosomally grown drug resistant and sensitive <it>M.tuberculosis </it>clinical isolates.</p> <p>Results</p> <p>On comparing the two dimensional (2-DE) gels, many proteins were found to be upregulated/expressed during intracellular state which were identified by matrix assisted laser desorption/ionization mass spectrometry (MALDI-MS). Four proteins (adenosylhomocysteinase, aspartate carbomyltransferase, putatitive thiosulfate sulfurtransferase and universal stress protein) were present in both intracellular MDR and sensitive isolates and three of these belonged to intermediary metabolism and respiration category. Two proteins (alanine dehydrogenase and adenosine kinase) of intracellular MDR isolate and two (glucose-6-phosphate isomerase and ATP synthase epsilon chain) of intracellular sensitive isolate belonged to intermediary metabolism and respiration category. One protein (Peroxidase/Catalase) of intracellular MDR and three (HSPX, 14 kDa antigen and 10 kDa chaperonin) of sensitive isolate belonged to virulence, detoxification and adaptation category. ESAT-6 of intracellular MDR belonged to cell wall and cell processes category. Two proteins (Antigen 85-C and Antigen 85-A) of intracellular sensitive isolate were involved in lipid metabolism while probable peptidyl-prolyl cis-trans isomerase A was involved in information pathways. Four (Rv0635, Rv1827, Rv0036c and Rv2032) of intracellular MDR and two proteins (Rv2896c and Rv2558c) of sensitive isolate were hypothetical proteins which were functionally characterized using bioinformatic tools. Bioinformatic findings revealed that the proteins encoded by Rv0036, Rv2032c, Rv0635, Rv1827 and Rv2896c genes are involved in cellular metabolism and help in intracellular survival.</p> <p>Conclusions</p> <p>Mass spectrometry and bioinformatic analysis of both MDR and sensitive isolates of <it>M. tuberculosis </it>during intraphagosomal growth showed that majority of commonly upregulated/expressed proteins belonged to the cellular metabolism and respiration category. Inhibitors of the metabolic enzymes/intermediate can therefore serve as suitable drug targets against drug-resistant and sensitive subpopulations of <it>M. tuberculosis</it>.</p

Free radial artery forearm flap reconstruction in various intraoral defects after tumour resection – Our experience

Background: A free radial forearm flap popularly known as “The Chinese flap” is the workhorse flap for oral cavity reconstruction after intraoral tumour resection. The aim was to highlight the versatility of the free radial artery forearm flap in various intraoral defects. Method: From 2017 to 2019, a total of 24 cases were operated for intraoral defect reconstruction after tumour resection by free radial artery forearm free flap. The patients had a mean age of 48 years (range 32-70). The most common histopathological diagnosis was squamous cell carcinoma in 22 cases. The free radial artery flap was used to reconstruct defects of tongue(8 cases), buccal mucosa(8 cases), lip(3 cases), retromolar trigone(3 cases) and the floor of mouth(2 cases).&nbsp; The mean flap size was 33cm2 and mean pedicle size was 8.7 cm. Results: Twenty four patients underwent intraoral reconstruction after tumor ablation with a free radial artery forearm fasciocutaneous flap. Two of the cases required immediate&nbsp; rexploration of which one could not be salvaged and was reconstructed with pectoralis major myocutneous flap. The success rate of the flap survival was 95.8% with satisfactory post operative outcome. Conclusion: The free radial artery forearm flap is a versatile, thin, pliable and reliable option for intraoral defect reconstruction after tumour ablation. The flap is easy to harvest with predictable vascular anatomy and a reasonable size of paddle for reconstructing various oral oncologic defect. Keywords: Free radial artery forearm flap, versatile, intraoral defect

Summary of the published Indian data on chronic myeloid leukemia

Chronic myelogenous leukemia (LML) was recognized as a distinct entity in the mid-1800s. Since Nowell and Hunagerford initiated their research on CML in1960 our understanding in CML has been increasing. Imatinib became the preferred treatment from 2000 onwards as a result of its unprecedented success. The lack of structured Indian data on CML led to the formation of a CML data cansortuim which invited CML data albiet retro spartive form around the country including major cancer service providers both government and private. We provide a summary of published Indian data on CML here

Cytomorphologic significance of marginal vacuoles in diffuse thyroid enlargements

Background: Fine needle aspiration cytology (FNAC) of the thyroid is an established first-line test for thyroid lesions. Marginal vacuoles (MVs) have been associated with hyperactivity of the thyroid, but some studies have pointed towards their nonspecific status. Aims: To assess the presence of MVs in diffuse thyroid enlargements and evaluate the strength of correlation between MVs, levels of thyroid hormone and cytological diagnosis. Materials and Methods: Ninety-seven cases of diffuse thyromegaly were studied. Cytomorphological features were examined with special attention to MVs. MVs were graded as scant, moderate and abundant. Hormonal status of the patients was recorded. The presence and grading of MVs was correlated with cytological diagnosis and hormonal status. The strength of association was studied by applying the Chi-square test and test of proportion; a P ? 0.05 was considered significant. ≤ 0.05 was considered significant. Results: Abundant MVs were not associated with hypothyroidism in this study; 79% of these cases were hyperthyroid. The correlation between moderate/insignificant MVs and functional status of the thyroid gland was inconclusive. Further, abundant MVs in thyroid FNACs were seen in cases of primary hyperplasia and Hashimoto′s thyroiditis. There was a significant correlation between the presence of abundant/moderate MVs and primary hyperplasia and their absence in colloid goiter (P = 0.01 and 0.004, respectively). Conclusions: A significant association was found between abundant MVs and a hyperthyroid state. Moderate/absent MVs in diffuse goiters were not found to correlate with thyroid function. Thus, all diffuse goiters with prominent MVs require hormonal evaluation to rule out hyperfunction of the thyroid