2,5-Diphenyl­penta-2,4-dienenitrile

In the title compound, C17H13N, the dihedral angle between the two phenyl rings is 17.6 (1)°. An inter­molecular C—H⋯N hydrogen bond is found in the crystal structure, also a C—H⋯π inter­action involving the phenyl ring at position 5

N′-(2-Methyl-3-phenyl­allyl­idene)nicotinohydrazide monohydrate

The asymmetric unit of the title compound, C16H15N3O·H2O, contains an N′-(2-methyl-3-phenyl­allyl­idene)nicotino­hydra­zide mol­ecule and a water solvent mol­ecule. The dihedral angle between the pyridine ring and the phenyl ring is 47.26 (5)°. Inter­molecular O—H⋯N, O—H⋯O, N—H⋯O and C—H⋯O hydrogen bonds are found in the crystal structure. Furthermore, C—H⋯π inter­actions involving the pyridine and phenyl rings are also found

t-3-Ethyl-r-2,c-6-bis­(2-fur­yl)piperidin-4-one

In the title mol­ecule, C15H17NO3, the piperidine ring adopts a chair conformation. The dihedral angle between the two furyl rings is 72.4 (1)°. The ethyl group and the furyl rings have equatorial orientations. Mol­ecules are linked by N—H⋯O hydrogen bonds

Effect of solvent change on chemical shifts of 4-benzyl-4-hydroxypiperidines

4-Benzyl-4-hydroxypiperidines 1-8 have been synthesized through Mannich reaction and were characterized through high resolution 1H and 13C NMR spectra in CDCl3.The conformational studies of the above eight compounds have been thoroughly done by using proton and 13C spectral data and the assigned conformations were also supported by Hybrid HF/DFT B3LYP/6-3G* calculations. These results are published earlier by us. In order to study the effect of solvent on the chemical shifts of these piperidines, 1H NMR spectra were recorded in C6D6 and DMSO-d6. The effect of change of solvents results appreciable change in the chemical shifts of various protons in the title compounds

N′-(3-Phenyl­allyl­idene)nicotinohydrazide monohydrate

In the title compound, C15H13N3O·H2O, the dihedral angle between the pyridine and phenyl rings is 35.45 (7)°. Inter­molecular O—H⋯O, O—H⋯N, N—H⋯O and C—H⋯O hydrogen bonds are found in the crystal structure. In addition, C—H⋯π inter­actions involving the pyridine and phenyl rings are also found

MISSING VALUE IMPUTATION AND NORMALIZATION TECHNIQUES IN MYOCARDIAL INFARCTION

Missing Data imputation is an important research topic in data mining. In general, real data contains missing values. The presence of the missing value in the data set has a major problem for precise prediction. The objective of this paper is to highlight possible improvement of existing algorithm for medical data. KNBP imputation method based on KNN and BPCA is proposed and evaluate MSE and RMSE estimates. Normalization is done by comparing three algorithms namely min-max normalization, Z-score and decimal scaling. The experiment is done with standard bench mark data and real time collected data. KNBP imputation method and Decimal Scaling Algorithm for Normalization got lower error rate

(1-Acetyl-2,6-diphenyl­piperidin-4-yl­idene)(phen­yl)acetonitrile

In the title mol­ecule, C27H24N2O, the piperidine ring adopts a boat conformation. The acetyl group at position 1 has a bis­ectional orientation. The two phenyl rings attached to the piperidine ring at positions 2 and 6 have bis­ectional and axial orientations, respectively, and make a dihedral angle of 75.27 (10)°. The phenyl­acetonitrile group at position 4 has an equatorial orientation. Mol­ecules are linked by C—H⋯N, C—H⋯O inter­molecular and C—H⋯π inter­actions. A C—H⋯O intra­molecular inter­action is also found in the mol­ecule

AN INVESTIGATION OF THE ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF AERIAL PARTS OF FLACOURTIA JANGOMAS

Objective: The present study was aimed to evaluate the analgesic and anti-inflammatory effects of leaf and stem part aqueous extract of Flacourtia jangomas. Methods: Aqueous extract of leaves (ALE) and aqueous extract stem (ASE) part of Flacourtia jangomas were sequentially prepared by maceration process and subjected to a preliminary phytochemical screening. The anti-inflammatory activity was assessed by the carrageenan-induced acute rat paw oedema model and Analgesic activity was evaluated by acetic acid-induced writhing model and hot plate method in mice. The data were analysed by one-way ANOVA followed by post hoc Dunnet’s test by using SPSS V.15 (student trail version). Results: The preliminary phytochemical analysis of extracts of leaves and stems indicated the presence of carbohydrate, alkaloids flavonoids, phenols, tannins, saponins. The extracts showed significant anti-inflammatory and analgesic activities with a dose-dependent manner. The ethanolic extract from the leave extract of Flacourtia jangomas at the dose 200 mg/kg has 55.6% significant anti-inflammatory activity compared to the standard drugs (44.4%). Even at the low dose leave extract has more potent than aqueous stem extract. Where in analgesic effect by Hot plate method basal reaction time results showed that aqueous extract of stem part at the dose of 200 mg /kg has a significant effect at 120 mts 10.0 sec when compared with std pentazocine 13.0 sec. In peripheral analgesic method Acetic acid-induced writhing model results have not shown much more significant when compared with standard drug (42.1%). The potential to cause anti-inflammation by stem extract was comparatively less than that of leave extract. Thus it could be concluded that Flacourtia jangomas leave extract possess significant anti-inflammatory activity Conclusion: Our findings suggest that Flacourtia jangomas extract is safe and has potential anti-inflammatory and analgesic activities, which promote this use as a food supplement against pain and inflammation related to inflammatory diseases

r-2,c-6-Bis(4-chloro­phen­yl)-t-3-isopropyl-1-nitro­sopiperidin-4-one

In the title mol­ecule, C20H20Cl2N2O2, the piperidine ring adopts a chair conformation and the nitroso group at position 1 has a bis­ectional orientation. The two benzene rings and the isopropyl group attached to the piperidine ring in positions 2, 6 and 3, respectively, have axial orientations. The dihedral angle between the two benzene rings is 21.56 (13)°. One of the Cl atoms is disordered over two positions in a 0.281 (5):0.719 (5) ratio. In the crystal structure, mol­ecules are linked by C—H⋯O hydrogen bonds and a short C—H⋯O contact occurs within the mol­ecule