Lipid profile pattern in controlled and uncontrolled diabetic patients in a tertiary care centre

Background: Diabetes Mellitus is a metabolic disorder characterized by hyperglycemia with disturbances of carbohydrate, lipid as well as protein metabolism virtually affecting every organ in the human body. Dyslipidemia is a group of biochemical disorders, which is frequently seen in diabetic individuals. Dyslipidemia associated with diabetes has a major role in atherosclerosis and cardiovascular complications.Methods: This cross-sectional study was conducted in diabetic patients visiting OPD of Shri Ram Murti Smarak Institute of Medical Sciences, Bareilly over a period of 6 months. A total of 320 patients were randomly selected for the study and divided into 2 groups depending on HbA1c levels.Results: BMI of controlled diabetics was 26.2±1.91 kg/m2 and of uncontrolled was 27.56±4.36 kg/m2 respectively with a statistically significant p value. Total Cholesterol levels in controlled group was 185.63±52.32 mg% and 217.83±61.33 mg% in uncontrolled group with a p value of 0.0005 which is highly significant. Same was seen in triglyceride and VLDL levels in controlled group which was 173.88±101.77 mg% and 31.5±12 mg% respectively and 203.33±83.7 mg% and 40.67±17.66 mg% in uncontrolled group respectively.Conclusions: The diabetic patients with poor glycemic control had statistically significant high values of Total Cholesterol, Triglycerides, VLDL levels and significant low HDL Levels. Good glycemic control can result in improvement in the lipid panel and the patients can be prevented from the high cardiovascular and neurological risk

Formulation and Evaluation of Fast Dissolving Oral Films of an Anti-Migrain Drug (Zolmitriptan)

Zolmitriptan known for its anti-migrain activity. The fast dissolving oral film of drug Zolmitriptan was designed in order to relief and ease the pain caused to patient suffering from Migraine followed by nausea, vomiting and sensitivity towards light/sound. The oral film was prepared using HPMC (Hydroxy Propyl Methyl Cellulose) as polymer and PEG as plasticizer by solvent casting method. The aim of preparing fast dissolving oral film of drug zolmitriptan was to have better Bioavability, quick onset of action (quick relief) and to prevent first pass metabolism. Films were subjected to physicochemical characterization such as thickness, weight variation, folding endurance drug content and were found to be satisfactory. The surface pH of all the films was found to be neutral. The results of the studies indicated that HPMC E50 could be used as a film forming polymer for the formulation. All the films prepared using HPMC E50 showed acceptable mechanical properties. On the basis of tensile strength, drug content and in vitro dissolution, formulation F3 was found to be the promising formulation showing better strength and good drug release profile. Also this formulation was stable for a period of 45 days with no significant change in drug content and drug release profile. Thus it could be said that the fast dissolving sublingual film of Zolmitriptan could be a better option for acute treatment of migraine attacks compared to the available conventional dosage forms. Keywords: Zolmitriptan, Fast dissolving, HPM