Phenotypic and Gene Expression Profiles of Embryo Development of the Ascidian Ciona robusta Exposed to Dispersants

Within EU approval policies, most dispersant ecotoxicity testing considers lethal concentrations for marine adult species, overlooking the embryotoxicological effects. Here we studied the ecotoxicity of two commercial dispersant formulations (dispersant A and B) on the embryogenesis of the ascidian Ciona robusta. Embryotoxicity and phenotypic alterations stated that dispersant B resulted more toxic than A (EC50 value of 44.30 and 160 µg mL−1, respectively) and induced severe larvae malformations at lower concentrations. Furthermore, the analysis of genes involved in different cellular response pathways indicated that those belonging to biotransformation were upregulated by dispersant A treatment, likely related to the presence of hydrocarbons. Instead, dispersant B induced cas8 gene downregulation, probably as a result of the prolonged exposure to mixture components. Our preliminary findings support the use of the C. robusta embryotoxicity test as a valuable tool for dispersant approval procedures, by providing sub-lethal responses on marine invertebrates closely related to vertebrates

Magnetoplasmon resonance in 2D electron system driven into a zero-resistance state

We report on a remarkably strong, and a rather sharp, photoresistance peak originating from a dimensional magnetoplasmon resonance (MPR) in a high mobility GaAs/AlGaAs quantum well driven by microwave radiation into a zero-resistance state (ZRS). The analysis of the MPR signalreveals a negative background providing experimental evidence for the concept of absolute negative resistance associated with the ZRS. When a system is further subject to a dc field, the maxima of microwave-induced resistance oscillations decay away and a system reveals a state with close-to-zero differential resistance. The MPR peak, on the other hand, remains essentially unchanged, indicating surprisingly robust Ohmic behavior under the MPR conditions.Comment: 4 pages, 2 figures; to appear in Phys. Rev. B - Rapid Communication

Green's-function theory of the Heisenberg ferromagnet in a magnetic field

We present a second-order Green's-function theory of the one- and two-dimensional S=1/2 ferromagnet in a magnetic field based on a decoupling of three-spin operator products, where vertex parameters are introduced and determined by exact relations. The transverse and longitudinal spin correlation functions and thermodynamic properties (magnetization, isothermal magnetic susceptibility, specific heat) are calculated self-consistently at arbitrary temperatures and fields. In addition, exact diagonalizations on finite lattices and, in the one-dimensional case, exact calculations by the Bethe-ansatz method for the quantum transfer matrix are performed. A good agreement of the Green's-function theory with the exact data, with recent quantum Monte Carlo results, and with the spin polarization of a $\nu=1$ quantum Hall ferromagnet is obtained. The field dependences of the position and height of the maximum in the temperature dependence of the susceptibility are found to fit well to power laws, which are critically analyzed in relation to the recently discussed behavior in Landau's theory. As revealed by the spin correlation functions and the specific heat at low fields, our theory provides an improved description of magnetic short-range order as compared with the random phase approximation. In one dimension and at very low fields, two maxima in the temperature dependence of the specific heat are found. The Bethe-ansatz data for the field dependences of the position and height of the low-temperature maximum are described by power laws. At higher fields in one and two dimensions, the temperature of the specific heat maximum linearly increases with the field.Comment: 9 pages, 9 figure

Large Bychkov-Rashba spin-orbit coupling in high-mobility GaN/AlGaN heterostructures

We present low temperature magnetoconductivity measurements of a density-tunable and high mobility two-dimensional electron gas confined in the wide bandgap GaN/AlGaN system. We observed pronounced anti-localization minima in the low-field conductivity, indicating the presence of strong spin-orbit coupling. Density dependent measurements of magnetoconductivity indicate that the coupling is mainly due to the Bychkov-Rashba mechanism. In addition, we have derived a closed-form expression for the magnetoconductivity, allowing us to extract reliable transport parameters for our devices. The Rashba spin-orbit coupling constant is $\alpha_{so}$ $\sim$ 6$\times$ 10$^{-13}$eVm, while the conduction band spin-orbit splitting energy amounts to $\Delta_{so}$ $\sim$ 0.3meV at n$_e$=1$\times10^{16}$m$^{-2}$.Comment: Accepted for publication in PR

Temperature dependence of spin polarizations at higher Landau Levels

We report our results on temperature dependence of spin polarizations at $\nu=1$ in the lowest as well as in the next higher Landau level that compare well with recent experimental results. At $\nu=3$, except having a much smaller magnitude the behavior of spin polarization is not much influenced by higher Landau levels. In sharp contrast, for filling factor $\nu=\frac83$ we predict that unlike the case of $\nu=\frac23$ the system remains fully spin polarized even at vanishingly small Zeeman energies.Comment: 4 pages, REVTEX, and 3 .ps files, To be published in Physical Review Letter

On-Chip Microwave Quantum Hall Circulator

Circulators are non-reciprocal circuit elements integral to technologies including radar systems, microwave communication transceivers, and the readout of quantum information devices. Their non-reciprocity arises from the interference of microwaves over the centimetre-scale of the signal wavelength in the presence of bulky magnetic media that break time-reversal symmetry. Here we realize a completely passive on-chip microwave circulator with size one-thousandth the wavelength by exploiting the chiral, slow-light response of a 2-dimensional electron gas (2DEG) in the quantum Hall regime. For an integrated GaAs device with 330 um diameter and 1 GHz centre frequency, a non-reciprocity of 25 dB is observed over a 50 MHz bandwidth. Furthermore, the direction of circulation can be selected dynamically by varying the magnetic field, an aspect that may enable reconfigurable passive routing of microwave signals on-chip

Novel Anticancer Drug 5H-pyro[3,2-a] Phenoxazin-5-one (PPH) Regulates lncRNA HOTAIR and HOXC genes in Human MCF-7 Cells

Breast cancer in women is the second most commonly cancer, after skin cancer. The percentage of mortalityrisk for breast cancer is 1 in 37 women (2.7%), which makes breast cancer represent the second cause of cancerdeath in women. Recently, new research based on previously published work in systemic chemotherapy andendocrine therapy field, have improved the incidence rates. The quinonic nucleus is common to many naturaland synthetic products associated with anticancer and antibacterial activities, these compounds are typicallyDNA-intercalating agents. The Class I Homeobox genes (HOX in human and hox in mouse) control embryonicdevelopment and specific determination of positional identity anteroposterior axis of the human body. The HOXgenes, are 39 transcription factors related to morphological, physiological disease. It has been demonstratedthat any deregulation into the network is able to induce neoplastic transformation. Particularly, HOXC locuscollaborating with lncRNA HOTAIR play a key role in breast cancer. In this study, our group evaluated the chemical and metabolic stability of new anticancer molecule 5H-pyro[3,2-a] phenoxazin-5-one (PPH). In a recent paper, we have already demonstrated that a new and potent anticancersynthetic iminoquinone, the 5H-pyrido[3,2-a]phenoxazin-5-one (PPH), is able to inhibit a large number oflymphoblastoid and solid-tumor-derived cells at submicromolar concentrations. Based on our previous research, we decided to analyze the cytotoxic effect and capability of PPH to control thelncRNA HOTAIR and HOXC locus gene expression in human breast cancer cells MCF-7, in order to demonstrateits role like potential new breast cancer antitumor drug

Novel anticancer drug 5h-pyro[3,2-a] phenoxazin-5-one (PPH) regulates lncRNA HOTAIR and HOXC genes in human MCF-7 cells

Breast cancer in women is the second most commonly cancer, after skin cancer. The percentage of mortality risk for breast cancer is 1 in 37 women (2.7%), which makes breast cancer represent the second cause of cancer death in women. Recently, new research based on previously published work in systemic chemotherapy and endocrine therapy field, have improved the incidence rates. The quinonic nucleus is common to many natural and synthetic products associated with anticancer and antibacterial activities, these compounds are typically DNA-intercalating agents. The Class I Homeobox genes (HOX in human and hox in mouse) control embryonic development and specific determination of positional identity anteroposterior axis of the human body. The HOX genes, are 39 transcription factors related to morphological, physiological disease. It has been demonstrated that any deregulation into the network is able to induce neoplastic transformation. Particularly, HOXC locus collaborating with lncRNA HOTAIR play a key role in breast cancer. In this study, our group evaluated the chemical and metabolic stability of new anticancer molecule 5H-pyro[3,2-a] phenoxazin-5-one (PPH). In a recent paper, we have already demonstrated that a new and potent anticancer synthetic iminoquinone, the 5H-pyrido[3,2-a]phenoxazin-5-one (PPH), is able to inhibit a large number of lymphoblastoid and solid-tumor-derived cells at submicromolar concentrations. Based on our previous research, we decided to analyze the cytotoxic effect and capability of PPH to control the lncRNA HOTAIR and HOXC locus gene expression in human breast cancer cells MCF-7, in order to demonstrate its role like potential new breast cancer antitumor drug

Effect of strain on stripe phases in the Quantum Hall regime

Spontaneous breaking of rotational symmetry and preferential orientation of stripe phases in the quantum Hall regime has attracted considerable experimental and theoretical effort over the last decade. We demonstrate experimentally and theoretically that the direction of high and low resistance of the two-dimensional (2D) hole gas in the quantum Hall regime can be controlled by an external strain. Depending on the sign of the in-plane shear strain, the Hartree-Fock energy of holes or electrons is minimized when the charge density wave (CDW) is oriented along [110] or [1-10] directions. We suggest that shear strains due to internal electric fields in the growth direction are responsible for the observed orientation of CDW in pristine electron and hole samples.Comment: 10 pages, 3 figure